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AN OBSERVATIONAL STUDY REGARDING PRESCRIPTION EVENT MONITORING OF ANTI-HYPERTENSIVE MEDICATIONS AMONGST PATIENTS COMING TO A TERTIARY CARE CENTRE OF NORTHERN INDIA
Hypertension is now defined on the basis of systolic (SBP) and diastolic (DBP) blood pressure levels and classified into stages on the basis of the degree of elevation. The generally recognized cut point for hypertension is an average office BP of 140/90 mmHg or greater, which has been obtained by a recommended standard technique with an accurate manometer and has been confirmed on at least one ot...
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REVISITING THE ROLE OF LOW DOSE RADIATION THERAPY AGAINST COVID-19 PNEUMONIA
Background: The entire world is battling the coronavirus disease (COVID-19) that potentially leads to pneumonia, Acute Respiratory Distress Syndrome (ARDS), multi-organ failure, often resulting in death. Therefore, the utmost challenge from a medical perspective is to improve lung function before the patient requires intubation and critical care. In the same light, the use of low dose radiation th...
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A PROSPECTIVE STUDY ON CORTICOSTEROID USAGE AND INCIDENCE OF CORTICOSTEROID-INDUCED HYPERGLYCEMIA IN A TERTIARY CARE HOSPITAL
Corticosteroids are a widely used class of drugs for respiratory, autoimmune, gastrointestinal, and dermatological conditions. Despite the efficacy of steroids, they have a wide variety of side effects. However, SIH remains the most misdiagnosed side effect. Undiagnosed SIH will precipitate DM, increases the morbidity and length of hospital stay, especially when pre-existing risk factors are prese...
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BIOLOGICAL PROPERTIES OF EXTRACTS FROM LOCALLY GROWN BANANA LEAVES INDICATE THEIR POSSIBLE USE FOR WOUND DRESSING IN ARUSHA, TANZANIA
This study assessed the biological properties and safety profile of extracts from locally grown banana leaves in Arusha (Tanzania), to affirm their possible use for wound dressing. Screening for phytoconstituents in extracts from studied banana plant species, ijuhi inkundu (IJ) mlelembo (ML) and kimalindi (KIM), revealed the presence of various secondary metabolites; anthraquinones, alkaloids, fla...
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STABILITY INDICATING ASSAY OF TELMISARTAN IN TABLETS
An accurate, simple, precise, rapid stability-indicating assay method was developed and subsequently validated for the estimation of Telmisartan in API and Tablets. The best separation of the drug was achieved on Kromasil C18 (4.6 × 150 mm, 5 µm) with the mobile phase consisted of mixture of 0.01 M Phosphate buffer (pH: 3) and Acetonitrile in ratio of (40:60%) at flow rate of 2 ml/min, with dete...
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IN-SILICO MODELING AND VALIDATION OF L-GLUTAMINASE ENZYME, AN ANTICANCER DRUG USING WEB-BASED COMPUTATIONAL TOOLS
The L-Glutaminase enzyme is a therapeutic agent that can be employed for the treatment of human cancer, specifically lymphocytic leukemia. Microbes are exploited commercially to produce L-Glutaminase on a large scale. The L-Glutaminase is an economic anti-cancer drug and can be easily administered into patients. The L-Glutaminase is also employed in food industries in the processing of fermented f...
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ENHANCEMENT OF SOLUBILITY OF AN ORAL HYPOGLYCAEMIC DRUG, GLIMEPERIDE BY THE TECHNIQUE COCRYSTALLISATION
Co-crystallization is one of the most reliable alternative approaches to increase the solubility of poorly water-soluble drugs without affecting their physicochemical properties. Pharmaceutical cocrystals are neutral organic compounds connected to the API preferentially by loosely formed bonds as dipole-dipole interaction. Our present study aims at improving the solubility of an effective oral hyp...
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BIOTECHNOLOGICAL APPLICATION OF PECTINASE
Pectinase is a collection of enzymes that degrade pectin into simpler compounds known as galacturonic acids. Microbes and plants largely produce pectinase, and it has a wide range of biotechnological applications in food, agriculture, industry, the environment and medicine. Fruit juices, coffee, cocoa, tea, jams and jellies are all made with pectinase in the food industry. Furthermore, pectinase, ...
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NEUROPROTECTIVE ACTIVITY OF SOLASODINE FROM SOLANUM XANTHOCARPUM FRUITS AGAINST CEREBRAL ISCHEMIA/REPERFUSION – INDUCED OXIDATIVE STRESS IN RAT
Ethnopharmacological Relevance: Traditional herb Solanum xanthocarpum contains solasodine as the chief constituent of fruits. Since analgesic, anti-inflammatory, anticonvulsant effects of fruits are reported; study was designed to rationalize the use of solasodine as neuro-protective with its mechanism of action. Aim of Study: Cerebrovascular Diseases (CVD) includes devastating disorders like isch...
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SYNTHESIS OF NEW 2, 5, 6-SUBSTITUTED IMIDAZO[2,1-B][1,3,4]THIADIAZOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS
A series of 2-cyclopropylimidazo [2,1-b] [1,3,4] thiadiazole derivatives 5(a-i) have been synthesized by reacting 5-cyclopropyl-1,3,4-thiadiazol-2-amine (3) and an appropriate 2-bromo-1,2-(substituted aryl) ethanones 4(a-i). Structures of these compounds were recognized by IR, 1H NMR, 13C NMR spectroscopy and Mass spectrometry. Hypoxia-inducible factor (HIF) has been identified as an important can...
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