Most Popular
STUDIES ON GC-MS PROFILING OF SOME SEAWEEDS OF MAHIM BEACH DIST. PALGHAR, MAHARASHTRA USING VARIOUS SOLVENTS
Objective: To investigate the bioactive constituents of Ulva lactuca, Sargassum prismaticum, and Sarconema filiforme using gas chromatography-mass spectrometry (GC-MS) analysis. Methods: 10 gm sample of each seaweed was successfully extracted with HPLC grade methanol and pet. ether with continuous shaking in a dark room for 36 h. The concentrated extracts were subjected to GC MS analysis. Results:...
990
755
EFFECT OF SHORT TERM DIETARY ZINC DEFICIENCY AND ZINC SUPPLEMENTATION ON WISTAR RAT ERYTHROCYTE: BIOCHEMICAL STUDIES
Deficiency of zinc has been reported in developed and developing countries due to low zinc intake, which also accounts for crops grown in low zinc areas. 2 billion people still remain at risk of zinc deficiency affecting all age groups in spite of proven benefits of adequate zinc nutrition. The study evaluates the effect of dietary zinc deficiency on male Wistar rat erythrocytes for 2-, 4- and 6 w...
989
472
ROLE OF DEOXYCHOLIC ACID IN MODULATING HUMORAL AND CELL MEDIATED IMMUNE SYSTEM
Deoxycholic acid (DCA) is a secondary bile salt that is a major active constituent of Chinese traditional medicine, “Niuhuang” which is known to have immunoregulatory and anti-inflammatory properties. Although data from the literature indicate possible immunomodulatory effects of Deoxycholic acid on the immune system, little has been reported regarding the mode of activity of DCA in modulating...
989
481
IN-VITRO ANTIOXIDANT AND ANTIDIABETIC ACTIVITY OF THE COMBINED S-ALLYL CYSTEINE AND TAURINE
Diabetes mellitus is one of the familiar metabolic disorders affecting the global population. In the modern system of medicine, there are still no satisfactory promising agents available for the effective management and treatment of diabetes. The current study aimed to investigate the in-vitro antioxidant and antidiabetic potential of the combination of s-allyl cysteine (a phytochemical) and tauri...
989
394
FORMULATION AND EVALUATION OF SUSTAIN RELEASE MATRIX TABLET OF FLUVOXAMINE MALEATE USING MORINGA OLEIFERA GUM
Fluvoxamine Maleate, an oral serotonin reuptake inhibitor, has been used widely for the treatment of anxiety. Sustained-release matrix-type drug delivery system has advantages over conventional modes of drug administration, enhancing drug bioavailability as it avoids the first-pass metabolism and improves patient compliance. Optimization of the formulation was performed by varying the concentratio...
988
681
BRAIN TARGETING OF WATER SOLUBLE DRUG THROUGH NASAL ROUTE USING FATTY ACID VESICLES
Fatty acid vesicles are novel vesicles incorporating fatty acids which enhance the brain targeting efficiency when compared to conventional liposomes. This study's objective was to prepare, characterize, and evaluate fatty acid vesicles for brain targeting of a water-soluble drug, atomoxetine HCl through nasal route. The atomoxetine HCl loaded fatty acid vesicles were prepared by using the reverse...
987
467
HYPOACIDIC ACTIVITY OF THE HERBAL EXTRACT; A STUDY ON THE INHIBITION OF PARIETAL CELL K+/H+ ATPase PUMP
Gastrointestinal tract disorders occur due to an imbalance of gastric acid secretion and defensive factors. Histamine receptor blockers and proton pump inhibitors are the most prominent therapies in the treatment of GI tract disorders. Inhibition of the K+/H+ ATPase pump blocks the secretion of gastric acid (HCl) from the parietal cells. The adverse effects of currently available drugs have oblig...
987
541
THE STUDY ON OPTIMIZATION OF SOLID ORAL FLOATING TABLETS-A REVIEW
The motivation behind composing this review on floating drug delivery systems (FDDS) was to incorporate the ongoing research article with a unique spotlight on the key system of floatation to accomplish gastric maintenance. The ongoing advancements of FDDS, including the physiological and formulation factors influencing gastric maintenance, ways to deal with configuration single-unit, and numerous...
987
599
INFLUENCE OF CULTURAL PARAMETERS ON THE PRODUCTION OF BIOACTIVE METABOLITES BY STREPTOMYCES RECTIVERTICILLATUS VJMS-8 ISOLATED FROM SOUTH COASTAL REGIONS OF ANDHRA PRADESH, INDIA
Adaptation of marine actinobacteria to extreme climatic conditions such as high salinity, high pressure and high temperature has modified their physiological conditions to survive and elaborate novel bioactive metabolites. Among the different actinobacterial strains isolated from coastal regions of Guntur District, Andhra Pradesh, India, one potent strain with broad-spectrum antagonistic activity ...
986
421
PROTECTIVE EFFECT OF NARINGIN AGAINST CEREBRAL INFARCTION INDUCED BY ISCHEMIC-REPERFUSION IN RATS
Background: Leukocytes play an important role in tissue apoptosis as scavengers and vital components of inflammation, which has been generated during ischemia-reperfusion injury. The present study aimed to investigate the cerebroprotective potential of naringin through anti-inflammatory mechanism. Methods: Cerebral infarction was induced through bi-lateral common carotid artery occlusion for 30 mi...
986
515