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NOVEL METHOD FOR SEPARATION AND QUANTIFICATION OF POTENTIAL IMPURITIES BY RP-HPLC FROM KSM STAGE TO API STAGE OF DABIGATRAN MESYLATE
Dabigatran mesylate is a novel oral anticoagulant that works by blocking the clotting protein thrombin. The present work describes the separation and quantification of potential impurities in a single HPLC method, which are generated from raw materials to API synthesis. This method is capable of separating and quantifying the fourteen impurities, produced from the intermediate stages to final drug...
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CHARACTERIZATION OF BIOACTIVE METABOLITES FROM MARINE MACROALGAE COLLECTED FROM VERAVAL COAST OF GUJARAT
Seaweeds are potential sources of bioactive molecules. They are known to be rich sources of proteins, carbohydrates, lipids, vitamins, minerals, and other secondary metabolites. To evaluate the presence of these compounds in marine macroalgae collected from Veraval coast of Gujarat, present studies was carried out. The methanol extract of six macroalgae species (Ulva lactuca, Ulva faciata, Acantho...
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IN-VITRO STUDY OF ANTI-DIABETIC, ANTI-CANCER AND ANTI-UROLITHIATIC ACTIVITY OF DIFFERENT EXTRACTS OF PROSOPIS JULIFLORA SEEDS
Plants and their parts are used to treat many infectious diseases due to the presence of phytoconstituents and avoid some side effects. The present study evaluated the phytochemicals, anti-diabetic, anti-urolithiatic, and anti-cancer activities of Prosopis juliflora seeds in various solvents such as aqueous, ethanol, and 85% ethanol. The preliminary works revealed the presence of secondary metabol...
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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL QUINAZOLINONE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS
A series of quinazolinone derivatives were synthesized and screened for anti-inflammatory activity. 5-chloro anthranilic acid undergoes acetylation in the presence of acetic anhydride and anhydrous sodium acetate to give 5-chloro-N-acetyl anthranilic acid as intermediate-I which upon cyclization in the presence of phosphorous pentaoxide, glacial acetic acid, and para aminobenzoic acid to yield 4-[...
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ANALYSIS OF BIOLOGICALLY ACTIVE COMPOUNDS IN JIMSON WEED LEAFS
Jimson weed (Datura stramonium) members of the Solanaceae plant family; serve as major folklore medicinal herbs. The biologically active compounds spectrum in leaves of Datura stramonium L. was investigated by GC-MS with NMR & FTIR analysis. Steroids, terpenoids, anticholinergic alkaloids, atropine, and scopolamine, are detected. Twenty of them are new constitutions for the species, and eight ...
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NANO STRUCTURED LIPID CARRIER SYSTEM- A NOVEL TARGETING CARRIER
Oral administration of drugs is considered a convenient route; however, various drugs that are insoluble in water or cannot permeate across gastrointestinal tract membrane cannot be delivered by this route. To enhance the permeability through the physiological barriers, lipophilic drugs are introduced but, lipophilic drugs have low oral bioavailability. To enhance the bioavailability, a third-gene...
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MEDICINAL PLANTS USED IN RICE BEER STARTER CULTURE BY DIFFERENT TRIBES IN ASSAM: AN ETHNOBOTANICAL SURVEY
The study represents the ethnobotanical information of the medicinal plants used by the six major communities of Assam, namely Mishing, Deori, Ahom, Tiwa, Bodo and Rabha, for better understanding of their local beliefs, customs, and tradition in the preparation of traditional rice beer starter culture. A semi-structured questionnaire was used focusing on the local names of the plants used in a sta...
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ANTI-CANCER POTENTIAL OF MORUSINDICA HYBRID VARIETIES IN HT-29 CANCER CELL LINES: AN EXPLORATORY STUDY
Complementary alternative medicine focuses on discovering the potential of plants in prevention and management of chronic diseases. Although Morus species has been screened for various biological activities, studies reporting the pharmacological effects of Morus indica (MI) hybrid varieties viz., V1 and S36 is scarce. This study focused on screening the phytochemical composition of Morus indica V1...
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DEVELOPMENT AND EVALUATION OF TRANSDERMAL DRUG DELIVERY OF SALBUTAMOL SULPHATE VIA ETHOSOMES
Asthma is a chronic disease; there is a need for a drug delivery system that maintains adequate therapeutic concentrations for a longer duration of action to improve better clinical efficacy. Salbutamol sulphate (SS) is a widely prescribed drug to treat asthma though it has short plasma half-life and undergoes extensive first-pass metabolism. Thus, it necessitates frequent administration by oral r...
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ORAL CANCER AND ITS EPIDEMIOLOGY, THERAPY AND RISK FACTORS, CASE STUDIES IN KARNATAKA: A REVIEW
Oral cancer is one of the lethal cancers, having first rank in India and sixth most deadly cancer in world and most of the time occurs due to improper lifestyle and adverse habits. Cancers of the lung, oral cavity, pharynx, larynx, esophagus, urinary bladder, renal, pelvic and pancreas are among the neoplastic diseases induced by smoking. Epidemiological studies have firmly identified the connecti...
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