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A SIMPLE, SENSITIVE AND FAST SINGLE STEP EXTRACTION METHOD FOR DETERMINATION OF EMPAGLIFLOZIN IN HUMAN PLASMA USING LC-MS/MS
A simple, sensitive, and fast single-step extraction method for estimating empagliflozin in human plasma using LC-MS/MS was developed and validated for pharmacokinetics evaluations. Plasma samples were basified before solid-phase extraction on SOLA (30 mg / 1 mL cartridges). Separations were carried out on a normal reverse phase C18 column (Hypersil BDS 100 × 4.6, 5µ mm column) for 3.5 minutes a...
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CHROMATOGRAPHIC EVALUATION OF OPTIMIZATION AND SEASONAL VARIATION OF BACOSIDE A CONTENT FROM WILD AND CULTIVATED BRAHMI (BACOPA MONNIERI LINN.) PLANT
Brahmi (Bacopa monnieri Linn.) is a miraculous Ayurvedic drug used commercially in memory-enhancing formulations. Its nootropic action is due to Bacoside A, which modern parameters have proved. Bacoside A content fluctuated during the course of the whole year. In the present study, High-Performance Liquid Chromatography was conducted to evaluate total Bacoside A content (expressed as the sum of Ba...
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A VALIDATED FORCED DEGRADATION METHOD FOR CHARACTERIZATION OF ATAZANAVIR DEGRADANTS BY LC-MS/MS
The validated stability-indicating analytical method was developed for quantification of Atazanavir using Atazanavir-D9 as an internal standard by UPLC-ESI-MS/MS. The method was validated according to United States Pharmacopeia (USP) guideline with respect to the accuracy, precision, specificity, linearity, solution stability, robustness, sensitivity, and system suitability. Forced degradation stu...
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EVALUATION OF ANTIMICROBIAL ACTIVITY OF SESUVIUM PORTULACASTRUM (L.) L. AND EXCOECARIA AGALLOCHA L.
Background: Sesuvium portulacastrum L. and Excoecaria agallocha (L.) are two important medicinal plants inhabited in mangrove regions. Early researches focused on antimicrobial activity of leaves of concerned plants with various solvents among which ethanol, chloroform, and methanol were the best Objective: In the present study the extracts of two therapeutic plants were researched to measure the ...
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ISOLATION, IDENTIFICATION OF NON-POLAR TERPENES AND TOTAL ANTIOXIDANT ACTIVITY FROM CHLOROFORM EXTRACT OF BOUGAINVILLEA GLABRA LEAVES
This study reports the isolation and antioxidant activity of non-polar terpenes extracted from the leaves of Bougainvillea glabra choicy. To characterize the phytochemical constituents of Bougainvillea glabra leaves using the GC-MS method. The 95% ethanol extract was filtered, distilled, and concentrated to obtain the solid greenish residue. The residue was further fractioned by n-hexane, chlorofo...
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CHARACTERIZATION AND IDENTIFICATION OF ACTIVE COMPOUND OF OCELLATED SNAKEHEAD (CHANNA PLEUROPHTHALMUS BLKR) WASTE CHARCOAL POTENTIAL AS ANTIALLERGY DRUG
Natural resources potentials, such as animals or plants, have been utilized as a traditional herb and can be benefitted for human health and to support the government program in medication to be back to nature. The body parts often used for the traditional drug are meat, horn, tail, feather, nail, fat, bile, and shell. The animal's potential to develop as medicine meets the following criteria: eas...
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LC-MS METHOD DEVELOPMENT AND VALIDATION FOR THE LOW-LEVEL DETERMINATION OF GENOTOXIC IMPURITY, ETHYL P-TOLUENE SULFONATE IN PERIN-DOPRIL TERT-BUTYLAMINE
Objective: Ethyl para toluene sulfonate is a genotoxic impurity and the current work’s primary objective is to develop a hyphenated and highly sensitive LC-MS method for the determination (EPTS) in Perindopril tert-butylamine. Method: EPTS was determined by LC-MS method in selective ion monitoring mode (SIM) using Atlantis T3 (150×4.6mm) 3.0 µm column. 0.01M ammonium acetate is utilized as buf...
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QUERCETIN DEVELOPS SENSITIVITY OF ADENOCARCINOMA CELLS TO RADIATION VIA LOWERING METASTASIS AND PROMOTING CASPASE-3 INDEPENDENT CELL DEATH
Quercetin (QCN) is a flavonoid available in fruits and vegetables, and it has shown several medicinal properties, including anticancer properties. However, the radiosensitizing properties of QCN on adenocarcinoma cells have not been greatly looked into yet. Thus in the present study, we investigate the effect QCN would have on the lung adenocarcinoma cell line NCI-H23 (H23) when QCN is combined wi...
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EVALUATION OF ANTIDEPRESSANT ACTIVITY OF CHENOPODIUM ALBUM EXTRACTS AND FRACTIONS IN MICE
Traditional systems of medicine emphasize the importance of life-style, including dietary habits, for maintaining holistic health. Ayurveda recommends the use of fruits and vegetables in our diet for maintaining mental health. Chenopodium album is one such popular green vegetable. This plant is rich in phenolic compounds – compounds that are valued for their antioxidant activity and potential fo...
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PHARMACOGNOSTIC AND ANTIMICROBIAL EVALUATION OF HORDEUM VULGARE LEAVES
Hordeum vulgare (Barley) grass is the best functional food for providing nutrition and eliminating toxins from human cells; however, its functional ingredients have also played an important role in health benefits. Flavonoids, saponarin, lutonarin, K, Ca, Se, dietary fiber, polysaccharide, alkaloid, glycoside, tannin, metallothionein and polyphenols are all found in barley grass. Microscopical stu...
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