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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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54.

A SIMPLE, SENSITIVE AND FAST SINGLE STEP EXTRACTION METHOD FOR DETERMINATION OF EMPAGLIFLOZIN IN HUMAN PLASMA USING LC-MS/MS

A simple, sensitive, and fast single-step extraction method for estimating empagliflozin in human plasma using LC-MS/MS was developed and validated for pharmacokinetics evaluations. Plasma samples were basified before solid-phase extraction on SOLA (30 mg / 1 mL cartridges). Separations were carried out on a normal reverse phase C18 column (Hypersil BDS 100 × 4.6, 5µ mm column) for 3.5 minutes a...

A. Raval, C. Prasad, R. S. R. Patil and A. C. Krishna *

College of Pharmacy, Pacific Academy of Higher Education and Research University, Udaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3457-63

3457-3463

2323

1302

57.

CHROMATOGRAPHIC EVALUATION OF OPTIMIZATION AND SEASONAL VARIATION OF BACOSIDE A CONTENT FROM WILD AND CULTIVATED BRAHMI (BACOPA MONNIERI LINN.) PLANT

Brahmi (Bacopa monnieri Linn.) is a miraculous Ayurvedic drug used commercially in memory-enhancing formulations. Its nootropic action is due to Bacoside A, which modern parameters have proved. Bacoside A content fluctuated during the course of the whole year. In the present study, High-Performance Liquid Chromatography was conducted to evaluate total Bacoside A content (expressed as the sum of Ba...

P. Wate *, P. Khobragade and A. Pargaonkar

Department of Dravyaguna, Datta Meghe Ayurvedic Medical College, Hospital and Research Centre, Wanadongari, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3481-89

3481-3489

2323

1436

76.

A VALIDATED FORCED DEGRADATION METHOD FOR CHARACTERIZATION OF ATAZANAVIR DEGRADANTS BY LC-MS/MS

The validated stability-indicating analytical method was developed for quantification of Atazanavir using Atazanavir-D9 as an internal standard by UPLC-ESI-MS/MS. The method was validated according to United States Pharmacopeia (USP) guideline with respect to the accuracy, precision, specificity, linearity, solution stability, robustness, sensitivity, and system suitability. Forced degradation stu...

A. Kota * and M. V. K. Valli

Department of Pharmaceutical Analysis, Vinayaka Mission's College of Pharmacy, Kondappanaickenpatti, Salem, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(2).1320-31

1320-1331

2321

1453

23.

EVALUATION OF ANTIMICROBIAL ACTIVITY OF SESUVIUM PORTULACASTRUM (L.) L. AND EXCOECARIA AGALLOCHA L.

Background: Sesuvium portulacastrum L. and Excoecaria agallocha (L.) are two important medicinal plants inhabited in mangrove regions. Early researches focused on antimicrobial activity of leaves of concerned plants with various solvents among which ethanol, chloroform, and methanol were the best Objective: In the present study the extracts of two therapeutic plants were researched to measure the ...

K. S. Kolli *, S. K. Ella, J. Suneetha and P. K. R. Kumar

Department of Botany, Adikavi Nannaya University Rajamahendravaram, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(2).904-09

904-909

2319

1144

53.

ISOLATION, IDENTIFICATION OF NON-POLAR TERPENES AND TOTAL ANTIOXIDANT ACTIVITY FROM CHLOROFORM EXTRACT OF BOUGAINVILLEA GLABRA LEAVES

This study reports the isolation and antioxidant activity of non-polar terpenes extracted from the leaves of Bougainvillea glabra choicy. To characterize the phytochemical constituents of Bougainvillea glabra leaves using the GC-MS method. The 95% ethanol extract was filtered, distilled, and concentrated to obtain the solid greenish residue. The residue was further fractioned by n-hexane, chlorofo...

J. M. J. Rani

Department of Chemistry, Annai Vailankanni Arts and Science College, Bishop Sundaram Campus, Thanjavur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1799-04

1799-1804

2318

1136

10.

CHARACTERIZATION AND IDENTIFICATION OF ACTIVE COMPOUND OF OCELLATED SNAKEHEAD (CHANNA PLEUROPHTHALMUS BLKR) WASTE CHARCOAL POTENTIAL AS ANTIALLERGY DRUG

Natural resources potentials, such as animals or plants, have been utilized as a traditional herb and can be benefitted for human health and to support the government program in medication to be back to nature. The body parts often used for the traditional drug are meat, horn, tail, feather, nail, fat, bile, and shell. The animal's potential to develop as medicine meets the following criteria: eas...

Aryani *, E. Suprayitno, B. B. Sasmito and Hardoko

Faculty of Fisheries and Marine Science, Brawijaya University, Malang, East Java, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.12(2).794-02

794-802

2316

1379

31.

LC-MS METHOD DEVELOPMENT AND VALIDATION FOR THE LOW-LEVEL DETERMINATION OF GENOTOXIC IMPURITY, ETHYL P-TOLUENE SULFONATE IN PERIN-DOPRIL TERT-BUTYLAMINE

Objective: Ethyl para toluene sulfonate is a genotoxic impurity and the current work’s primary objective is to develop a hyphenated and highly sensitive LC-MS method for the determination (EPTS) in Perindopril tert-butylamine. Method: EPTS was determined by LC-MS method in selective ion monitoring mode (SIM) using Atlantis T3 (150×4.6mm) 3.0 µm column. 0.01M ammonium acetate is utilized as buf...

S. K. Susarla *, S. Duvvuri and B. M. Rao

Gandhi Institute of Technology and Management, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2257-62

2257-2262

2316

1337

38.

QUERCETIN DEVELOPS SENSITIVITY OF ADENOCARCINOMA CELLS TO RADIATION VIA LOWERING METASTASIS AND PROMOTING CASPASE-3 INDEPENDENT CELL DEATH

Quercetin (QCN) is a flavonoid available in fruits and vegetables, and it has shown several medicinal properties, including anticancer properties. However, the radiosensitizing properties of QCN on adenocarcinoma cells have not been greatly looked into yet. Thus in the present study, we investigate the effect QCN would have on the lung adenocarcinoma cell line NCI-H23 (H23) when QCN is combined wi...

L. Kma and T. J. Baruah *

Department of Biochemistry, Assam Royal Global University, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2842-52

2842-2852

2316

1078

21.

EVALUATION OF ANTIDEPRESSANT ACTIVITY OF CHENOPODIUM ALBUM EXTRACTS AND FRACTIONS IN MICE

Traditional systems of medicine emphasize the importance of life-style, including dietary habits, for maintaining holistic health. Ayurveda recommends the use of fruits and vegetables in our diet for maintaining mental health. Chenopodium album is one such popular green vegetable. This plant is rich in phenolic compounds – compounds that are valued for their antioxidant activity and potential fo...

A. Sharma, S. Kaur and R. Shri *

Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2707-15

2707-2715

2315

1187

20.

PHARMACOGNOSTIC AND ANTIMICROBIAL EVALUATION OF HORDEUM VULGARE LEAVES

Hordeum vulgare (Barley) grass is the best functional food for providing nutrition and eliminating toxins from human cells; however, its functional ingredients have also played an important role in health benefits. Flavonoids, saponarin, lutonarin, K, Ca, Se, dietary fiber, polysaccharide, alkaloid, glycoside, tannin, metallothionein and polyphenols are all found in barley grass. Microscopical stu...

Kiran, Vandana Garg * and Saloni Kakkar

Department of Pharmaceutical Sciences M. D. University, Rohtak, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3414-20

3414-3420

2315

1154