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OPTIMIZATION, CHARACTERIZATION AND PHARMACOLOGICAL ACTIVITY OF BERBERINE LOADED NANOPARTICLES – AN APPROACH TO IMPROVE THE EFFICACY OF ANTICONVULSANT AND ANTIOXIDANT ACTIVITY
Berberine, an isoquinoline alkaloid that has better anticonvulsant and antioxidant activities, results in less efficacy due to poor solubility, poor permeability, poor stability and poor drug delivery to the brain. Hence, this study aim at improving Anticonvulsant and Antioxidant activities of Berberine by formulating nanoparticles with three-factor two-level boxbehnken with design expert software...
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EFFICACY OF PSORINUM IN CHRONIC URTICARIA: A CASE REPORT
Chronic urticaria is a popular skin complaint that is characterized by wheals of various sizes surrounded by erythema and associated with itching and burning as a consequence of Type1 hypersensitivity reaction mediated by IgE antibodies to specific allergen. Most of the population (>20%) have urticaria once somewhere in the life. The conventional management of this condition is associated with ...
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SCOPE OF NANOTECHNOLOGY IN NUTRACEUTICALS, COSMECEUTICALS AND DENTISTRY – REVIEW
Nanotechnology is predicted to change health care essentially. The word nano originates from the Greek word "dwarf". The idea of nanotechnology was first explained in 1959 by Richard Feynman. Nanotechnology has applications in many fields, including Medicine, Diagnostics, Drug delivery, Tissue engineering, Pharmaceuticals, Cosmeceuticals, Nutraceuticals, Dental materials, the Food industry etc. N...
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A COMPREHENSIVE REVIEW ON RECENT ADVANCEMENT IN ALLOPATHY AND AYURVEDA IN THE MANAGEMENT OF EPILEPSY
Millions of people throughout the world suffer with epilepsy, a neurological illness that frequently results in seizures. Epilepsy has been treated using both allopathic and ayurvedic medicinal methods. Antiepileptic medications (AEDs) are used by allopathic medicine, commonly referred to as contemporary medicine, to manage seizures. Several AEDs have been created recently in allopathic medicine, ...
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HEPATOPROTECTIVE ACTIVITY OF DORSTENIA BRASILIENSIS AGAINST ACUTE HEPATITIS INDUCED BY ACETAMINOPHEN AND CARBON TETRACHLORIDE IN MICE
The aim of this study was to assess the influence of extract of D. brasiliensis (CEDb) on acute liver injuries induced by both acetaminophen, and carbon tetrachloride in mice as an initial step to validate its popular use. A liquid-chromatography method coupled to Mass Spectrometry showed the presence of coumarins dorstenin, bergapten, and psoralene in CEDb. Swiss albino male mice were pre-treated...
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PREVALENCE OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) IN CLINICAL SPECIMENS AND AMONG HOSPITAL STAFF NASAL CARRIERS IN KHARTOUM STATE
Staphylococcus aureus is a bacteria that causes a heavy epidemic disease burden worldwide. This study aimed to investigate the prevalence of Methicillin-Resistant Staphylococcus aureus (MRSA) and the presence of mecA gene as a virulence factor of S. aureus isolates from clinical isolates and hospital staff nasal carriers using a conventional PCR. A cross-sectional study involving eighty-one S. aur...
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DEVELOPMENT AND VALIDATION OF A SIMPLE UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF FENTANYL CITRATE BOTH IN BULK AND MICRO-EMULSION FORMULATION
Objective: Development of simple, rapid, and accurate UV spectrophotometric method for the estimation of Fentanyl citrate (FC) in a bulk and pharmaceutical dosage form. The proposed method was validated according to the guidelines of the International Conference on Harmonization and the Association of Official Analytical Chemists International. Methods: The method was based on the measurement of a...
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FABRICATION, OPTIMIZATION AND EVALUATION OF CHRONOTROPIC DRUG DELI-VERY SYSTEM OF CAPTOPRIL
The present investigation was based on the development and evaluation of chronotropic capsules for hypertension treatment. Captopril has ACE inhibitor action to prevent the circadian rhythm related to hypertension. The solubility of captopril in the GI tract was pH-dependent i.e., captopril soluble only at 1.2 pH, show better stability, and absorbed in the upper part of the gastrointestinal tract....
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CHROMATOGRAPHIC EVALUATION OF OPTIMIZATION AND SEASONAL VARIATION OF BACOSIDE A CONTENT FROM WILD AND CULTIVATED BRAHMI (BACOPA MONNIERI LINN.) PLANT
Brahmi (Bacopa monnieri Linn.) is a miraculous Ayurvedic drug used commercially in memory-enhancing formulations. Its nootropic action is due to Bacoside A, which modern parameters have proved. Bacoside A content fluctuated during the course of the whole year. In the present study, High-Performance Liquid Chromatography was conducted to evaluate total Bacoside A content (expressed as the sum of Ba...
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FORCED DEGRADATION STUDY OF ROSUVASTATIN AND TENELIGLIPTIN, CHARACTERISATION OF ITS DEGRADATION PRODUCTS BY VARIOUS ANALYTICAL TECHNIQUES: A REVIEW
Rosuvastatin is a widely used lipid-lowering medication that belongs to the class of “Statins” whereas Teneligiptin is a novel potent drug that belongs to the class of “DPP-4 inhibitors” which is used for the treatment of Type 2 Diabetes mellitus. The FDA recently approved the combination of these two drugs in 2021 since it proved to be highly effective for treating dyslipidemia associated...
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