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EVALUATION OF ANTIMICROBIAL ACTIVITY OF SESUVIUM PORTULACASTRUM (L.) L. AND EXCOECARIA AGALLOCHA L.
Background: Sesuvium portulacastrum L. and Excoecaria agallocha (L.) are two important medicinal plants inhabited in mangrove regions. Early researches focused on antimicrobial activity of leaves of concerned plants with various solvents among which ethanol, chloroform, and methanol were the best Objective: In the present study the extracts of two therapeutic plants were researched to measure the ...
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PREVALENCE OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) IN CLINICAL SPECIMENS AND AMONG HOSPITAL STAFF NASAL CARRIERS IN KHARTOUM STATE
Staphylococcus aureus is a bacteria that causes a heavy epidemic disease burden worldwide. This study aimed to investigate the prevalence of Methicillin-Resistant Staphylococcus aureus (MRSA) and the presence of mecA gene as a virulence factor of S. aureus isolates from clinical isolates and hospital staff nasal carriers using a conventional PCR. A cross-sectional study involving eighty-one S. aur...
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IMPLEMENTATION OF ROBOTICS AND ARTIFICIAL INTELLIGENCE IN THE PHARMACEUTICAL SECTOR
The rapid development of artificial intelligence (AI) has far-reaching consequences for the global economy. Computers are helping with human input, decision-making, and data provision in medicine more than ever before. AI, algorithms, robotics, and big data are all used in today's healthcare sector and the medical profession to derive inferences for monitoring large-scale medical trends and detect...
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A VALIDATED FORCED DEGRADATION METHOD FOR CHARACTERIZATION OF ATAZANAVIR DEGRADANTS BY LC-MS/MS
The validated stability-indicating analytical method was developed for quantification of Atazanavir using Atazanavir-D9 as an internal standard by UPLC-ESI-MS/MS. The method was validated according to United States Pharmacopeia (USP) guideline with respect to the accuracy, precision, specificity, linearity, solution stability, robustness, sensitivity, and system suitability. Forced degradation stu...
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ANTIOXIDANT DRUG USED IN THE TREATMENT OF RESERPIN INDUCED PARKINSON DISEASE IN RATS
Parkinson's infection is a neurodegenerative issue portrayed by the cardinal manifestations of solidness, resting tremor, gradualness (bradykinesia) and decrease of development (hypokinesia). It is a maturing populace and in spite of the fact that there have been a few significant leaps forward as far as the treatment of this crippling illness, for example, drugs levodopa, dopamine [DA] agonists,...
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HEPATOPROTECTIVE ACTIVITY OF DORSTENIA BRASILIENSIS AGAINST ACUTE HEPATITIS INDUCED BY ACETAMINOPHEN AND CARBON TETRACHLORIDE IN MICE
The aim of this study was to assess the influence of extract of D. brasiliensis (CEDb) on acute liver injuries induced by both acetaminophen, and carbon tetrachloride in mice as an initial step to validate its popular use. A liquid-chromatography method coupled to Mass Spectrometry showed the presence of coumarins dorstenin, bergapten, and psoralene in CEDb. Swiss albino male mice were pre-treated...
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EXTENSIVE STUDY ON RETT SYNDROME: A CASE REPORT
Rett Syndrome is an extremely rare, post-natal, and serious genetic neurodevelopmental syndrome that occurs mostly in female children. It occurs due to the mutations in the MeCP2 gene of the X chromosome. Children with Rett syndrome are usually diagnosed within 24 months of their age. The mutation takes place on the S421 site of the MeCP2 gene. The information for coding MeCP2 protein is obtained ...
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NANO STRUCTURED LIPID CARRIER SYSTEM- A NOVEL TARGETING CARRIER
Oral administration of drugs is considered a convenient route; however, various drugs that are insoluble in water or cannot permeate across gastrointestinal tract membrane cannot be delivered by this route. To enhance the permeability through the physiological barriers, lipophilic drugs are introduced but, lipophilic drugs have low oral bioavailability. To enhance the bioavailability, a third-gene...
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QUALITATIVE PHARMACOGNOSTIC AND PHYTOCHEMICAL EVALUATION ON ACHYRANTHES ASPERA LINN. LEAF
Medicinal plants and their investigation towards the phytoconstituents is much interested in today’s research. The plant Achyranthes aspera Linn. is one of the most use full drugs in Siddha and Ayurvedha medicines for treating various diseases in different formulations. Here the aim of this study is to evaluate the pharmacognostic parameters and identify the phytoconstituents. A preliminary ph...
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ANALYSIS OF BIOLOGICALLY ACTIVE COMPOUNDS IN JIMSON WEED LEAFS
Jimson weed (Datura stramonium) members of the Solanaceae plant family; serve as major folklore medicinal herbs. The biologically active compounds spectrum in leaves of Datura stramonium L. was investigated by GC-MS with NMR & FTIR analysis. Steroids, terpenoids, anticholinergic alkaloids, atropine, and scopolamine, are detected. Twenty of them are new constitutions for the species, and eight ...
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