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ANTIBACTERIAL ACTIVITY OF SOME COMMON KITCHEN SPICES AGAINST ESCHERICHIA COLI, STAPHYLOCOCCUS AUREUS, SALMONELLA TYPHIAND PSEUDOMONAS AERUGINOS
The current study investigated and compared the antibacterial activity of common kitchen spices; Ginger, Turmeric, Bay leaf, and Coriander, against Escherichia coli, Staphylococcus aureus, Salmonella Typhi, and Pseudomonas aeruginosa. The antibacterial activity of different spices was calculated by the agar well cup plate method. The concentrations, 75%, 50%, and 25%, were made for all the test sp...
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SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL CHALCONES WITH METHANE-SULFONYL END AS POTENT ANALGESIC AND ANTI-INFLAMMATORY AGENTS
In the present study, eleven new chalcones bearing a methanesulfonyl group at para position have been synthesized by the condensation of 4-methylsulphonylacetophenone with different para-substituted aromatic aldehydes. The structures of the newly synthesized molecules were elucidated by spectroscopic methods such as as1H NMR, 13C NMR, and mass. These compounds were screened for their anti-inflamma...
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IN-VITRO IMMUNOMODULATORY AND CYTOTOXICITY POTENTIAL OF NATURAL COMPOUNDS FROM FRAGARIA NUBICOLA
Introduction: Reactive oxygen species and nitric oxide play a major role in the physiopathology of inflammatory diseases, neurodegenerative disorders, autoimmune pathologies and immunodeficiency. With this understanding targeting oxidative stress could be a promising approach in new drug discovery. Methodology: Therefore, new compounds that were isolated from methanolic extract of leaves of wild s...
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IN-SILICO ANALYSIS OF MTA1 AS DRUG TARGET AGAINST NATURAL ANTIOXIDANTS
The protein MTA1 with histone deacetylase activity is a member of the nucleosome remodeling complex encoded by the mta1 gene is frequently overexpressed in biologically aggressive epithelial neoplasms. MTA1 is a nuclear co-regulatory molecule that is highly expressed in many cancers and correlates with tumor metastasis and progression. MTA1 alters signaling events in the tumor micro-environment. M...
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THE THEORETICAL STUDIES OF MOLECULAR ORBITALS AND THERMODYNAMIC PROPERTIES OF ANTIFUNGAL DRUG
In this work, the molecular structure optimization, electronic properties like local chemical reactivity descriptors (Fukui function analysis for reactive site prediction), and thermodynamic properties (Heat capacity, entropy, zero points vibrational energy, thermal energy, translational, rotational and vibrational energy) of antifungal drugs were theoretically computed. In this work also, electro...
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INVESTIGATION OF THE ANTI-CANCER POTENCY OF NANOMEDICINE, GREEN SYNTHESIZED FROM SPIRULINA PLATENSIS, AGAINST BREAST CANCER
Breast cancer is the most common type of cancer found in women. Although considerable advances have been achieved in the diagnosis and treatment of breast cancer, medical research routinely thrives towards the development of newer technologies for the treatment of breast cancer. The current study aimed at the development of nanomedicine, in the form of silver nanoparticles from the aqueous extract...
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NEPHROPROTECTIVE EFFECT OF CUMINUM CYMINUM SEEDS EXTRACT ON DIABETIC MICE MODEL
Diabetes mellitus is a metabolic condition characterized by insulin resistance, or poor secretion, or both. There are several side effects associated with drugs available to cure diabetes. The most common side effect is neurodegenerative. The objective of the present research was to evaluate the efficacy of Cuminum cyminum seed against diabetes and also to evaluate its nephroprotective power in th...
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PHYTOCHEMICAL SCREENING AND IN-VITRO ANTIOXIDANT ACTIVITIES OF VARIOUS EXTRACTS OF HELICHRYSUM PETIOLARE HILLIARD & B.L. BURTT USED FOR THE TREATMENT OF DIABETES MELLITUS IN THE EASTERN CAPE PROVINCE OF SOUTH AFRICA
Helichrysum petiolare is a herbal plant used in the Eastern Cape of South Africa to treat asthma, chest problems, colds, coughs, infections, diabetes, and high blood pressure. This study aimed to evaluate the phytochemical components and antioxidant activities of the acetone, ethanol, cold, and boiled aqueous extracts of H. petiolare. The phytochemical contents of the acetone, ethanol, and boiled ...
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STRUCTURE BASED VIRTUAL SCREENING IN SEARCH OF POTENTIAL INHIBITORS AGAINST HGPRT AS TARGET FOR PLASMODIUM FALCIPARUM
Malaria is a parasitic infectious disease transmitted through the bite of female Anopheles mosquitos. Every year, approximately 210 million Peoples are suffering from this dangerous disease, and around 440,000 individuals pass from this infectious disease. Recently, the Indonesia Ministry of Health declared that the malaria pre-elimination stage should be reached by 2020 and be free of malaria tra...
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EFFECT OF CHROMIUM ON IN-VITRO GROWTH AND ANTIOXIDANT POTENTIAL OF DIANTHUS CARYOPHYLLUS L.
Catalase, guaiacol peroxidase and polyphenol oxidase are antioxidant enzymes that are important in the metabolism of reactive oxygen species and can be induced by environmental stresses including chromium (Cr), heavy metal toxic to living organisms. In-vitro regenerated shoots of carnation (Dianthus caryophyllus L.) were exposed to K2Cr2O7, and the activities of these antioxidant enzymes were anal...
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