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PHARMACOGNOSTIC AND ANTIMICROBIAL EVALUATION OF HORDEUM VULGARE LEAVES
Hordeum vulgare (Barley) grass is the best functional food for providing nutrition and eliminating toxins from human cells; however, its functional ingredients have also played an important role in health benefits. Flavonoids, saponarin, lutonarin, K, Ca, Se, dietary fiber, polysaccharide, alkaloid, glycoside, tannin, metallothionein and polyphenols are all found in barley grass. Microscopical stu...
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LYMPHATIC TARGETING SYSTEM USING NANO-FORMULATION: CHALLENGES AND APPROACHES
The lymphatic system is the subpart of the systemic circulation for maintaining immune function; this system is mainly known as a drainage system to removes foreign bodies. This system consists of various lymphoid organs and tissues. The lymphatic system based on physiological function as absorption and micro-particulate uptake by these routes the bioavailability and efficacy were enhanced and und...
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EVALUATION OF PLASMA GLUCOSE AND SERUM LIPID PROFILE LEVELS AMONG STUDENTS IN NNEWI CONSUMING GLYCINE MAX (SOYA BEAN)
Medicinal plants are becoming globally recognized because of their acclaimed therapeutic potentials. This study evaluated the plasma glucose and serum lipid profile levels among university students consuming Glycine max (Soya bean) in Nnewi, Nigeria. A total of thirty (30) apparently healthy male subjects aged between 18 and 30 years were randomly recruited from medical students to serve as both t...
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EXERCISE-INDUCED OXIDATIVE STRESS MANAGEMENT BY METHANOLIC EXTRACT OF ZINGIBER OFFICINALIS ON SOME VITAL TISSUES IN MALE RAT
Background: Zingiber officinalis known as ginger, under the family Zingiberaceae, is a popular food spice and occupies an important place in Ayurvedic and traditional medicine. Its rhizome is used as antioxidative, carminative and for chronic diseases. Aims: Study indicated the curative effects of methanolic extract of ginger on severe exercise-induced oxidative damage in vital organs. Materials a...
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SCREENING OF PHYTOCHEMICALS, GC-MS BASED PHYTOCONSTITUENTS PROFILING AND ANTIBACTERIAL EFFICIENCY OF LEAVES EXTRACTS OF ANISOMELES MALABARICA
The present study aimed to determine the phytochemical components of the leaf extracts of A. malabarica, antimicrobial, antioxidant activities and GC-MS analysis. The leaves extracts have folklore and traditional applications in India. The polar and non-polar solvents extracts such as methanol, ethyl acetate, chloroform, hexane and water were used for various phytochemical analysis proved the exis...
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PREPARATION, EVALUATION AND CHARACTERIZATION OF STARCH AND GRAFTED STARCH
The aim of this study was to synthesize the graft copolymer of starch to obtain materials that profit from the particular properties of both natural and synthetic polymeric material. Thus in the present work, a graft copolymer of methyl acrylate and potato starch has been synthesized under microwave irradiation using K2S2O8-TU redox pair, which generates free radical sites on the starch backbone w...
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BIOLOGICAL SCREENING AND PHYTOCHEMICAL INVESTIGATION OF MERREMIA EMARGINATA LEAVES
The dried leaves of Merremia emarginata Burm. F were screened for antitubercular, cytotoxic, and anti-inflammatory activities. The antimycobacterial activity of compounds was assessed against Myco-bacterium tuberculosis using microplate Alamar Blue assay (MABA), and the cytotoxic activity was studied on Hela (Human cervical carcinoma), MCF-7 (Human breast carcinoma) cell lines. A prenylflavonoid, ...
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A STUDY ON THE ADVERSE DRUG REACTIONS OF HIV-TB CO-INFECTED PATIENTS IN A TERTIARY CARE HOSPITAL OF NORTH EAST INDIA – A PROSPECTIVE COHORT STUDY
The reporting of adverse drug reactions after taking any medicines is very much essential to establish a safe patient profile for drugs. The co-infection of HIV and TB has been a major concern for the healthcare system, and the various drugs interaction from taking ART and ATT should be highlighted to avoid unwanted reactions. The present study was conducted in a hospital set up for a period of on...
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NOVEL METHOD FOR SEPARATION AND QUANTIFICATION OF POTENTIAL IMPURITIES BY RP-HPLC FROM KSM STAGE TO API STAGE OF DABIGATRAN MESYLATE
Dabigatran mesylate is a novel oral anticoagulant that works by blocking the clotting protein thrombin. The present work describes the separation and quantification of potential impurities in a single HPLC method, which are generated from raw materials to API synthesis. This method is capable of separating and quantifying the fourteen impurities, produced from the intermediate stages to final drug...
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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL QUINAZOLINONE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS
A series of quinazolinone derivatives were synthesized and screened for anti-inflammatory activity. 5-chloro anthranilic acid undergoes acetylation in the presence of acetic anhydride and anhydrous sodium acetate to give 5-chloro-N-acetyl anthranilic acid as intermediate-I which upon cyclization in the presence of phosphorous pentaoxide, glacial acetic acid, and para aminobenzoic acid to yield 4-[...
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