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FABRICATION AND EVALUATION OF ELASTOSOMES OF BOSWELLIA SERRATA FOR TRANSDERMAL DRUG DELIVERY
The extracts of Boswellia serrata possess notable medicinal uses. Boswellia serrata is a highly lipophilic drug. It undergoes extensive hepatic first-pass metabolism. The t1/2 is approximately 6 h. There are reported side effects with the administration of Boswellia serrata. This research work aims to fabricate Elastosomes which get hold of many desired features for transdermal drug delivery. The ...
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DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC METHOD FOR THE ESTIMATION OF SOFOSBUVIR
A simple stability-indicating high-performance thin-layer chromatographic method which is economic, selective, and precise for analysis of Sofosbuvir (SFB), both as a bulk drug and in formulations, was developed and validated according to ICH guidelines. The method employed HPTLC precoated Merck TLC plates RP-18 F254 as the stationary phase while the solvent system prepared by mixing n-Hexane: Eth...
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CHEMICAL COMPOSITION AND ANTIMICROBIAL PROPERTIES OF DIFFERENT BASIL OILS
The aerial parts essential oils of Ocimum basilicum (Lamiaceae) from Togo were steam-distilled and investigated for their percentage composition (GC and GC/MS) and in vitro antimicrobial activities. Five oil chemotypes were identified and classified as follows in line with their principal components: estragole type; linalool/estragole type; methyleugenol type; methyleugenol/t-anethole type; taneth...
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CHARACTERIZATION AND PHARMACODYNAMIC EVALUATION OF DEVELOPED MICROEMULSION FOR NASAL DRUG DELIVERY
In the present study, we had developed Asenapine maleate (ASNM) loaded microemulsion (ME) to increase the solubility of Asenapine maleate by components of microemulsion including formulation concern, characterization, mucosal diffusion, stability and nasal ciliotoxicity of Asenapine maleate microemulsion (AME). For nasal delivery of Asenapine maleate, a challenge existing in formulation developmen...
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ISOLATION AND CHARACTERIZATION OF MULTI-DRUG RESISTANT (MDR) AND EXTENSIVELY DRUG RESISTANT (XDR) BACTERIA FROM DIVERSE ENVIRONMENTAL NICHES
Antimicrobial resistance (AMR) emerged as a major challenge to public health and significantly impacting the global economy. Infections due to multi-drug resistant (MDR) bacteria are difficult to treat and cause financial burden on patients. Environment may serve as a genetic pool of several drug resistant genes and help bacteria to emerge as notorious superbugs. This study aimed to characterize M...
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RELATIVE STRUCTURAL ANALYSIS OF LytTR DOMAIN OF AgrA PROTEIN INVOLVED IN BACTERIAL QUORUM SENSING
Resistance to antimicrobials by pathogenic bacteria is a global menace. An attractive pathway to resolve this problem of resistance may be achieved by targeting the bacterial quorum sensing (QS) process. Fighting bacterial infections by interfering with their command language and disrupting virulence expression could serve as a viable alternative. One of the current strategies is to attenuate viru...
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PARENTS AWARENESS RELATED TO CHILD ABUSE MEASURES: A SAUDI COMMUNITY-BASED STUDY
Background: Child abuse is a common episode, but rarely predictable. Therefore, this study aimed to assess the parent's awareness related to child abuse measures. Methodology: This was a cross-sectional survey of 400 Saudi parents about child abuse-related factors. All participants were 20 years or older. Results: Out of the 400 parents, 96/400(24%) (41/175 (23.4%) were fathers, and 55/225 (24.4%)...
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A REVIEW ON THE MITOCHONDRIAL DYSFUNCTION IN SPORADIC PARKINSON’S DISEASE
Parkinson’s disease is the second most common progressive, age-linked neurodegenerative disorder. The sporadic form of the disease is usually idiopathic, where mitochondrial dysfunction is its major hallmark. Mitochondria are multifunctional dynamic organelles that carry out major cellular functions that get damaged by reactive oxygen species, deposition of lewy bodies, dopaminergic neuronal cel...
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WATTAKAKKA VOLUBILIS-AN OVERVIEW
Wattakaka volubilis (L. f) Stapf, belonging to the family of Asclepiadaceae, has a history of use in traditional medicine in numerous countries. Traditionally the plant has been used for the treatment of diabetes, eye infections, snake bites, boils, skin problems, jaundice etc. A tribal community called Kurinjan has been using this plant to reduce blood glucose level. This plant is a tall woody cl...
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TOPICAL DRUG DELIVERY OF KETOCONAZOLE ENTRAPPED TRANSFEROSOMAL GEL WITH DESIGN AND ENACTMENT
In pharmaceutical research, the transdermal route of drug delivery has gained great interest, Trasferosomes is a novel vesicular drug carrier system that is composed of water, surfactant, and phospholipids; these were introduced in the early 1990s. The mechanism on which drugs absorb through skin is “osmotic gradient”. Transferosomes, when applied on the skin surface it diffuses into skin laye...
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