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PRELIMINARY STUDIES ON ARTEMISIA ANNUA L. (ASTERACEAE) GROWN IN GHANA: MORPHOLOGY, MICROSCOPY AND ARTEMISININ YIELD
Artemisia annua L. is an herbaceous plant from which the antimalarial sesquiterpene lactone, Artemisinin, is obtained. In Ghana, Artemisinin-Combination therapies are used as first-line treatment for managing malaria. The present study, the first of its kind in Ghana, sought to carry out the preliminary morphological and phytochemical evaluation and investigate the artemisinin content of Artemisia...
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COMPARITIVE REVIEW ON ANTI-ULCER ACTIVITY OF SOME MEDICINAL PLANT EXTRACTS
Peptic ulcer is an excavation of mucosa and may extend to the submucosal layer. The bacterium Helicobacter pylori is regarded as the most common cause of infection. Long-term use of NSAIDs (non-steroidal anti-inflammatory disease drugs) like Aspirin, Diclofenac, and Naproxen and stress were also regarded as causes of ulceration. Ancient technology of synthesizing and utilizing plant-based medicine...
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A RAPID SPECTROPHOTOMETRIC DETERMINATION OF NI(II) IN MEDICINAL PLANT MATERIALS AND WATER SAMPLES USING N’,N”’-((1E,1’E)-(PROPANE-1,3-DIYLBIS (SULFANEDIYL)) BIS(1-(4-BROMOPHENYL) ETHAN-2-YL-1-YLIDENE)) BIS(2-HYDROXYBENZOHYDRAZIDE) AS A SELECTIVE AND SENSITIVE ANALYTICAL REAGENT
N',N'''-((1E,1'E)-(propane-1,3-diylbis (sulfanediyl)) bis (1-(4-bromophenyl) ethan-2- yl-1-ylidene)) bis (2-hydroxybenzohydrazide) (BAPSSHZ) is found to be a selective and sensitive analytical reagent for the determination of trace levels of nickel (II) in environmental samples like medicinal plant materials and water samples (potable and polluted) by spectro-photometry. BAPSSHZ reacts with Ni (II...
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DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF LAMIVUDINE AND TENOFOVIR DISOPROXIL FUMARATE IN COMBINED DOSAGE FORM USING QUALITY BY DESIGN APPROACH
A new, simple, rapid, accurate, and economical method has been developed for the simultaneous estimation of Lamivudine and Tenofovir Disoproxil Fumarate in formulation by using a quality by design approach. Design expert software was used for QbD analysis. 03 level factorial quadratic design models were used to analyze the response. The model generated was found to be significant. The optimized co...
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PROTECTIVE EFFECT OF CURCUMIN ON LIPID PEROXIDATION AND ANTIOXIDANT STATUS AGAINST CADMIUM CHLORIDE TOXICITY IN HEART (AURICLES AND VENTRICLES) OF ALBINO MICE
Cadmium can cause various health problems even at low concentrations by inducing oxidative damage in tissues of organisms. Nowadays, the focus has been raised toward the use of herbal treatment against heavy metal toxicity. Hence, the present research work was aimed to investigate the protective effect of curcumin against Cd-induced toxicity in the auricles and ventricles of the heart in albino mi...
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CARDIOPROTECTIVE EFFECT OF AESCIN ON ANTIOXIDANT AND LIPID PROFILE IN ISOPROTERENOL-INDUCED MYOCARDIAL INFARCTION IN RATS
The efficacy of aescin on the liver and cardiac markers, lipid profile, and antioxidant status in rats with myocardial infarction (MI) induced by isoproterenol (ISO) was investigated in this study. Three doses of aescin (5, 10, and 20 mg/kg of b.w) were administered to rats for the first 21 days. After the treatment period, ISO (60 mg/kg of b.w) was given subcutaneously to the rats on the 22nd and...
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COMPARATIVE STUDY OF ANTI-ANXIETY AND ANTI-DEPRESSANT POTENTIALS OF LEAVES AND ROOT OF METHANOLIC EXTRACT FROM ACHYRANTHES BIDENTATA BLUME ON MICE
Anxiety and Depression is the most prominent and crippled Neuropsychiatric Disease. World Health Organization (WHO) reported is the most burdensome disease of society. We therefore aimed at evaluating the Anti-Anxiety and Anti-depressant potential using Achyranthes bidentata Blume (Chinese name Huainiuxi). This study compared Leaves and Root part of Achyranthes bidentata methanolic extract (ABME) ...
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SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NOVEL 2, 3-DIHYDRO-1, 5-BENZOTHIAZEPINE DERIVATIVES
In the present investigation, a series of some novel 4-[substituted-2-hydroxy-phenyl]-2-(4′-dimethylamino-phenyl)-2, 3-dihydro-1, 5-benzothizepines (2a-l) have been synthesized by the treatment of 1-(substituted-2-hydroxy-phenyl)-3-(4′-dimethylamino-phenyl)-prop-2-en-1-ones (chalcones) (1a-l) with 2-aminothiophenol using ethanol as a solvent in the presence of catalytic amount of Lanthanum Nit...
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ANTITUMORIGENIC EFFECT OF VARIOUS PARTS OF FICUS RACEMOSA IN DALTON LYMPHOMA ASCITES TUMOR INDUCED SWISS ALBINO MICE
Medicinal plants play an important role in the development of potent therapeutic agents. In recent years there has been an increased interest in using of herbal medicines. To assess the antioxidative and antitumorigenic efficacy of methanolic extract of bark, fruits, and leaves of Ficus racemosa in Dalton Lymphoma Ascites tumors transplanted Swiss albino mice. The results showed that the cytotoxic...
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DNA CLEAVAGE STUDIES OF SOME COMPLEXES OF SCHIFF BASE PYRIMIDINE ONE DERIVATIVES
A series of metal complexes, namely, Ni (II), Zn (II), Cu (II) and Pt (II), have been synthesized with newly prepared biologically active ligands. These ligands and their functional groups were carefully designed and selected to display DNA cleavage effect. Schiff base compoundof 2 - methyl - 3 - aminobenzopyrimidine - 4 - one (L1) was prepared by condensation of an equimolar mixture of 2-methyl-3...
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