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PHYTOCHEMICAL INVESTIGATION, ISOLATION AND CHARACTERIZATION OF BETULIN FROM LEAF OF GYMNOSPORIA MONTANA
Ethnomedicinal plant-like Gymnosporia montana belonging to the family Celastraceae is commonly known as Vikalo in Gujarat. Ethanomedicinally, fresh leaves of Vikalo are chewed in trible regions of Gujarat to cure jaundice. Phytochemical screening of the plant showed the presence of phytoconstituents like phenol, flavonoids, alkaloids, triterpenoids, and saponin. The present study was undertaken fo...
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A COMPREHENSIVE REVIEW ON PSIDIUM GUAJAVA LINN: AS AN HERBAL REMEDY
Psidium guajava Linn is an herbal remedy used in Ayurveda as a traditional system of medicine in ethnomedicine. It is a tropical evergreen plant that grows in tropical and subtropical climates. It has a wide variety of nutritional components. The whole plant and various parts of the plants possess different types of therapeutic activity, such as Tannin, phenols, triterpenes, flavonoids, essential ...
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TOPICAL DRUG DELIVERY OF KETOCONAZOLE ENTRAPPED TRANSFEROSOMAL GEL WITH DESIGN AND ENACTMENT
In pharmaceutical research, the transdermal route of drug delivery has gained great interest, Trasferosomes is a novel vesicular drug carrier system that is composed of water, surfactant, and phospholipids; these were introduced in the early 1990s. The mechanism on which drugs absorb through skin is “osmotic gradient”. Transferosomes, when applied on the skin surface it diffuses into skin laye...
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EVALUATION OF MYCOPLASMA HOMINIS PROTEOME TO IDENTIFY THE POTENTIAL VACCINE CANDIDATE PROTEINS
Objective: Mycoplasma hominisis a gram-negative bacteria belonging to class Mollicutes that is commonly present in men and women of reproductive age. At present, there is no effective prophylaxis for Mycoplasma hominis, as it has gained resistance for the drugs hence an in-silico approach was undertaken to find out the peptide-based vaccine for the pathogen. Methods: In women, it affects the genit...
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DESIGN AND EVALUATION OF CHRONOTHERAPEUTIC ANTI-HYPERTENSIVE COMBINATION THERAPY USING MINI-TABLETS TECHNOLOGY
Hypertension or elevated blood pressure (BP) is a serious medical condition that significantly increases the risks of heart, kidney, brain, and other diseases. In persons with normal BP and uncomplicated essential hypertension, BP falls to the lowest levels during the nighttime sleep, and rises suddenly with morning awakening, and reaches the peak during the initial h of diurnal activity. The opti...
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TO STUDY THE ANTI-INFLAMMATORY PROPERTIES OF AQUEOUS EXTRACT OF LEAVES OF IMPATIENS BALSAMINA IN EXPERIMENTAL ANIMAL MODELS
The present study was undertaken to study the anti-inflammatory effects of aqueous extract of Impatiens balsamina leaves in suitable animal models. The leaves of Impatiens balsamina were extracted with distilled water using the Soxhlet apparatus. The extract thus obtained was screened for anti-inflammatory activity using Cotton pellet implantation method, Granuloma pouch method, and formaldehyde a...
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A REVIEW ON COMPUTER AIDED DRUG DESIGN IN DRUG DISCOVERY
Computer-aided drug design programs use mathematical formulas to predict the property value and structure of stable, unknown, and molecular species. Quantum mechanics, hybrid QM/MM, molecular bonding, molecular modelling, molecular mechanics, and QSAR are some of the techniques used in molecular bonding studies. An average drug discovery cycle, from lead identification to clinical trials, is expec...
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PLANT MEDIATED GREEN SYNTHESIS OF SILVER NANOPARTICLES USING RUMEX OBTUSIFOLIUS LEAF EXTRACT AND THEIR ANTIBACTERIAL ACTIVITY
Rumex obtusifolius, belonging to the Polygonaceae family, commonly known as ‘broad-leaf-dock’ is one of the most important medicinal plants. It is common wayside weeds and uses as an antidote to nettle, depurative, astringent, laxative, and tonic and in the treatment of sores, blisters, jaundice, burns, cancer, and tumors. In this study, we design to synthesize silver nanoparticles from silver...
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IN-VITRO ANTIBACTERIAL ACTIVITIES OF EXTRACTS OF YEMENI PLANTS MYRTUS COMMUNIS L. AND FLEMINGIA GRAHAMIANA WIGHT & ARN.
Yemen is located on the southwestern brink of the Arabian Peninsula. The methanolic and aqueous crude extracts of two Yemeni traditional medicinal plants Myrtus communis L. and Flemingia grahamiana Wight & Arn were evaluated for antibacterial activity in-vitro by Well- diffusion method against six bacterial pathogens, Staphylococcus aureus, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella...
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IDENTIFICATION AND DOCUMENTATION OF EDIBLE INSECTS OF VESPA AFFINIS IN NAGALAND BY USING DNA BARCODE TECHNIQUES
DNA bar-coding is an ordered strategy that utilizes a little genetic marker in insect DNA to distinguish animal categories, as well as unidentified species. The present investigation manages the utilization of COI gene sequences in the distinguishing proof and documentation of edible insects in Nagaland. More than 2000 types of edible insects are recorded in more than 300 ethnic groups all around ...
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