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IN-VITRO EVALUATION OF PLEIOTROPIC PROPERTIES OF ROSUVASTATIN
Rosuvastatin, a selective and competitive inhibitor of enzyme 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, is marked as a first-choice drug amongst lipid-lowering agents because of its unique pharmacological and pharmacokinetic properties. An additional advantage of rosuvastatin administration is its specific, non-lipid pleiotropic properties, which are considered promising new fields of rese...
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A NEW WAY OF METHOD ESTABLISH AND VALIDATED OF RELATED SUBSTANCE OF GLASDEGIB BY RP-HPLC AND ITS FORCED DEGRADATION STUDY
A novel, simple, and accurate, high-performance liquid chromatographic method has been a developed with quantitative analysis of Glasdegib using Waters X-Bridge C18 150 × 4.6mm, 3.5µ column with a flow rate of 1ml/min. The buffer containing 0.1% OPA and the mixture of two components like Buffer and Acetonitrile in the ratio of 50: 50 is used as mobile phase. The detection was carried out at 250n...
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DEVELOPMENT AND STANDARDIZATION OF STABILITY INDICATING UV-SPECTROPHOTOMETRIC METHOD FOR ASSESSMENT OF BILASTINE IN BULK AND PHARMACEUTICAL DOSAGE FORMULATION
The objective of the present work is to develop and standardize the UV-Spectrophotometric method for the assessment of Bilastine in bulk and pharmaceutical dosage forms. On account of not much work being reported on the drug Bilastine and also it is a new second-generation anti-histamine molecule. Hence it is necessary in this context to relook into the older methods and further research for new...
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ANTI-PROLIFERATIVE AND APOPTOSIS INDUCING EFFECT OF NARAVELIA ZEYLANICA L. AGAINST LUNG CANCER CELL LINE A549
Cancer is one of the most dangerous diseases globally, and it appears due to extreme free radical damage, some chemicals, and a lack of physical activity which dispute causes damage to the cellular DNA, protein, and lipids. A number of treatment methods are available, but they cause unwanted side effects. The use of plant-derived products in the treatment of cancer prominently reduces adverse and ...
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CHEMOPREVENTIVE EFFICACY OF ZINGERONE ON MASTOCYTE INFLAMMATION, CELL PRO-LIFERATION AND APOPTOSIS AGAINST DMBA-INCITED MAMMARY CARCINOGENESIS IN FEMALE SPRAGUE-DAWLEY RATS
Zingerone is an active phenolic acid and the least pungent component of Zingiber officinale. It is known to exhibit different pharmacological properties which include anti-inflammatory, antioxidant, anticancer and antimicrobial activities. But, so far there has been no information available on the role of zingerone in experimental breast carcinogenesis. The objective of this experiment is to untwi...
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ANTIMICROBIAL ACTIVITY OF HYDRO-ALCOHOLIC BARK EXTRACT OF PONGAMIA PINNATA
Kanuga (Pongamia pinnata), a plant belonging to Leguminosae described in Vedas has ethnobotanical importance and a variety of medicinal properties. Pongamia pinnata, commonly grown on the roads of India is used to heal wounds, treat many fungal infections, skin diseases and to clean teeth. The objective of the current study is to perform phytochemical analysis and appraise the antimicrobial activi...
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AN IN-VITRO STUDY ON THE ANTI-ANGIOGENIC EFFECT OF MAJORANA HORTENSIS LEAVES
Angiogenesis is an inevitable process of tumour growth, invasion, and metastasis. Understanding the process of new blood vessel formation has gained prime importance recently, and anti-angiogenic therapy has now been considered as an important strategy for cancer therapy. Many bioactive compounds, especially of plant origin, have been explored for their anti-angiogenic potential. The present study...
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DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF SUSTAINED FLOATING HOLLOW MICROSPHERES CONTAINING LABETALOL HCL FOR THE TREATMENT OF HYPERTENSION
Aim: The present work for the development and in-vitro evaluation of sustained floating hollow microspheres (SFHM). Materials and methods: Sustained floating hollow microspheres were prepared by means of HPMC K4M, ethylcellulose and sodium alginate in various concentrations by using the solvent evaporation method using dichloromethane as solvent. The floating hollow microspheres of Labetalol HCl w...
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A STUDY ON THE ADVERSE DRUG REACTIONS OF HIV-TB CO-INFECTED PATIENTS IN A TERTIARY CARE HOSPITAL OF NORTH EAST INDIA – A PROSPECTIVE COHORT STUDY
The reporting of adverse drug reactions after taking any medicines is very much essential to establish a safe patient profile for drugs. The co-infection of HIV and TB has been a major concern for the healthcare system, and the various drugs interaction from taking ART and ATT should be highlighted to avoid unwanted reactions. The present study was conducted in a hospital set up for a period of on...
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THE MYSTERY AND HISTORY OF ALZHEIMER’S DISEASE
Even though the malady of dementia has existed for thousands of years, the correlated neurodegenerative alterations taking place in certain regions of the human brain were detected in recent times. Today, we are aware that dementia is a primary manifestation of Alzheimer’s disease (AD). In 1907, Alöis Alzheimer described the symptoms of a 51-year-old woman, Auguste Deter, who was under his obse...
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