Most Popular
CHEMOPREVENTIVE EFFICACY OF ZINGERONE ON MASTOCYTE INFLAMMATION, CELL PRO-LIFERATION AND APOPTOSIS AGAINST DMBA-INCITED MAMMARY CARCINOGENESIS IN FEMALE SPRAGUE-DAWLEY RATS
Zingerone is an active phenolic acid and the least pungent component of Zingiber officinale. It is known to exhibit different pharmacological properties which include anti-inflammatory, antioxidant, anticancer and antimicrobial activities. But, so far there has been no information available on the role of zingerone in experimental breast carcinogenesis. The objective of this experiment is to untwi...
979
480
EVALUATION OF ANTICONVULSANT, ANTIANXIETY ACTIVITY OF IPOMOEA PES-TIGRIDIS EXTRACTS IN MICE
Ipomoea pes-tigridis (IP) is a twinning hairy herb grown in India. Based on the ethnopharmacological information of the plant, the ethanolic extract of the whole plant of Ipomoea pes-tigridis was evaluated for its anticonvulsant, antianxiety activity in mice. The Antiepileptic activity was assessed by using MES (maximal electroshock) model (200 and 400 mg/kg), and antianxiety activity was assessed...
978
469
ESTIMATION OF FOSTEMSAVIR USING A NOVEL HPLC ANALYTICAL METHOD
Fostemsavir was quantified using a simple and reliable HPLC technique developed and validated. PhenomenexC18 column was used to achieve chromatographic segregation (150 x 4.6 mm, 5m). The mobile phase was a 55:45 mixture of 0.01N disodium orthophosphate and acetonitrile pumped through the column at 1.0ml/min. The temperature was maintained at 30 °C and the buffer used was 0.01N sodium dihydrogen ...
978
601
STRESS STUDIES OF METFORMIN AND GLICLAZIDE BY HPLC METHOD AND EXTENSION OF METHOD APPLICATION FOR ELUTION OF SOME ANTIVIRAL, ANTI-BACTERIAL AND ANTI-INFLAMMATORY DRUGS
A simple reverse phase SI-HPLC method was developed for the simultaneous estimation of antidiabetic combination of metformin and gliclazide. The method was based on HPLC separation on a reversed-phase C18 column using a mobile phase consisting of phosphate buffer: acetonitrile (40:60, v/v) at a flow rate of 0.8 ml/min. UV determination was achieved at 240 nm. The analytes were subjected to various...
977
597
EVALUATION OF ADDITION OF PARACETAMOL AS ADD ON THERAPY TO LOW DOSE ETORICOXIB FOR ANALGESIA IN ACUTE PAIN: AN EXPERIMENTAL STUDY
Objective: To study the influence of paracetamol on analgesia when given separately with low dose etoricoxib for treatment of acute pain in mice. Materials and methods: Animals were divided into 6 groups consisting of six animals in each group. Dose was calculated by using conversion factor for mice from human dose. Group I, II, III and IV received 2% Gum acacia 10ml/kg, paracetamol 84.5mg/kg, eto...
976
521
IN-VITRO ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF SALIX ALBA L. ALONG WITH SIMULTANEOUS HPTLC ANALYSIS OF SALICIN AND FERULIC ACID
Now a day’s interest towards natural and has been growing due to the unhealthy consequences of chemicals in the health industry; though, herbal substances possess several quality control and confirm pharmacological action issues. This present study was designed to determine the effects of Salix alba L. methanolic extract (MESAL) for its antioxidant and anti-inflammatory activity in rat models. F...
976
431
QUALITATIVE PHARMACOGNOSTIC AND PHYTOCHEMICAL EVALUATION ON ACHYRANTHES ASPERA LINN. LEAF
Medicinal plants and their investigation towards the phytoconstituents is much interested in today’s research. The plant Achyranthes aspera Linn. is one of the most use full drugs in Siddha and Ayurvedha medicines for treating various diseases in different formulations. Here the aim of this study is to evaluate the pharmacognostic parameters and identify the phytoconstituents. A preliminary ph...
974
451
FORMULATION AND EVALUATION OF AL+3 -INDUCED GELLAN GUM-DILLENIA INDICA L. FRUIT GUM-BLENDED MICROBEADS FOR SUSTAINED DRUG RELEASE
The current communication deals with the development of Al3+ -ion induced ionotropically gelled microbeads made of deacetylated gellan gum (GG) and Dillenia indica L. fruit gum (DG) blends for sustained release of drugs. Aceclofenac (ACE) was utilized as a model drug candidate in the current study. These GG-DG microbeads of ACE were formulated by ionotropic gelation using AlCl3 as ionotropic cross...
974
516
ANTIOXIDANT AND ANTIDEPRESSANT ACTIVITIES OF ETHANOLIC LEAF EXTRACT OF MANILKARA ZAPOTA
Aim: The present investigation deals with the preliminary phytochemical screening, in vitro antioxidant, and in vivo antidepressant activity of ethanolic leaf extract of Manilkara zapota. Materials and Methods: In-vitro antioxidant activity was evaluated using AS free radical scavenging parameters using Hydroxyl radical scavenging assay, phosphor molybdenum antioxidant assay and NO scavenging acti...
972
474
ANTIMYCOBACTERIAL SCREENING OF SELECTED MEDICINAL PLANTS USING MTT AND THE MICROPLATE RESAZURIN ASSAY
Tuberculosis holds one of the top places on the list of the main cause of death in India. At times, the patients fail to respond to treatment with anti-Tb drugs, drug resistance being one of the reasons. The increasing incidence of MDR and XDR-TB highlights the urgent need to search for newer anti-Tb drugs. For last many years, plants have beneficial activity in a different types of diseases produ...
971
520