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TOXICITY EVALUATION AND BEHAVIOURAL CHANGES OF LABEO ROHITA EXPOSED TO ETHION 50% EC
Modernization and intensification of agricultural production is generally accompanied by a rapid increase in the use of chemical fertilizers and pesticides. Ethion 50% EC is a broad-spectrum organophosphate insecticide used to control insects, mites, and nematodes by soil, foliar, and seed treatment applications, mainly on potatoes, sugar beet, rice, and maize, citrus. The aim of the present study...
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CAUSES, DIAGNOSIS AND MANAGEMENT OF MALE INFERTILITY: PHYTOCOMPOUNDS AS NATURAL SERMs- A REVIEW
Infertility is an inability to achieve pregnancy in spite of regular, unprotected coitus in one year. Infertility affects about 15% of couples, in which the malefactor contributes to 40% worldwide. There are various risk factors, causes, and treatment modalities for male infertility, of which Selective Estrogen receptor modulators (SERMs) are one of the promising treatments available for treating ...
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NEUROPROTECTIVE ACTIVITY OF SOLASODINE FROM SOLANUM XANTHOCARPUM FRUITS AGAINST CEREBRAL ISCHEMIA/REPERFUSION – INDUCED OXIDATIVE STRESS IN RAT
Ethnopharmacological Relevance: Traditional herb Solanum xanthocarpum contains solasodine as the chief constituent of fruits. Since analgesic, anti-inflammatory, anticonvulsant effects of fruits are reported; study was designed to rationalize the use of solasodine as neuro-protective with its mechanism of action. Aim of Study: Cerebrovascular Diseases (CVD) includes devastating disorders like isch...
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EFFECT OF FEW INDIGENOUS PLANT EXTRACTS ON CALCIUM OXALATE CRYSTALLIZATION WITH REFERENCE TO UROLITHIASIS
Preliminary screening study had employed to extract inhibitors of calcium oxalate (CaOx) crystallization in-vitro from four plant species, namely Saraca asoca, Berginia ciliata, Boerhavia diffusa, and Crateva nurvala These plants were selected based on their frequent medicinal usage by folks. Plant material (150 g) used for this study was successively extracted with Soxhlet apparatus using the sol...
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ASSESSING PHARMACOTHERAPEUTIC MANAGEMENT OF ANEMIA IN VARIOUS STAGES OF CHRONIC KIDNEY DISEASE AND POST RENAL TRANSPLANT PATIENTS
Introduction: Anemia in CKD occurs when the kidneys are damaged or diseased. They cannot make enough EPO, which stimulates the bone marrow to produce RBC. It is associated with increased cardiovascular diseases, hospitalization, reduced quality of life, cognitive impairment, and mortality. Materials and Methods: A prospective observational study was conducted on CKD patients. Demographic details, ...
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PHARMACOKINETIC DRUG INTERACTIONS BETWEEN HMG-COA REDUCTASE INHIBITORS PITAVASTATIN WITH CONCOMITANTLY USED TICAGRELOR
In the present research, the pharmacokinetic Drug-drug interactions between HMG-COA reductase inhibitors Pitavastatin with concomitantly used Ticagrelor have been studied. Pitavastatin is a member of the blood cholesterol lowering medication class of statins while Ticagrelor is a platelet aggregation inhibitor. Combination therapy with statins and other cardiovascular medications is recommended fo...
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FORMULATION AND EVALUATION OF SOLID DISPERSION TABLET CONTAINING TINIDAZOLE
This study focused on the development and evaluation of solid dispersions of Tinidazole, aimed at creating a fast-release tablet formulation. The preparation involved using carriers such as PEG 4000 and HPMC. Solid dispersions were created using both solvent evaporation and fusion methods. The resulting solid dispersions exhibited desirable properties, appearing as fine and free-flowing powders. I...
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DEVELOPMENT AND EVALUATION OF POMALIDOMIDE SUPERSATURABLE SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM FOR IMPROVED SOLUBILITY AND DISSOLUTION RATE
Background: Pomalidomide belongs to BCS class IV drug with low solubility and undergoes first-pass metabolism leads to reduced bioavailability of 15%. Objective: The current study aimed to develop pomalidomide Super saturable-SNEDDS to enhance solubility. Methods: Preliminary solubility studies were performed to identify oil, surfactant, and co-surfactant ratios. Pseudo tertiary phase diagram cons...
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EVALUATION OF METHANOLIC EXTRACT OF MACROTYLOMA UNIFLORUM SEEDS ON INHIBITION OF CALCIUM OXALATE CRYSTALLIZATION- IN-VITRO
Seeds of Macrotyloma uniflorum Linn. (Fabaceae) are widely used for treatment in kidney stones in India. In This study evaluates the in-vitro effect of methanolic extract of Macrotyloma uniflorum (MEMU) on calcium oxalate crystallization. A methanolic extract of M. uniflorum seeds at different concentrations (250-1500 μg/ml) was subjected to in-vitro crystallization activity. The obtained results...
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BIOTRANSFORMATION OF QUERCETIN BY ASPERGILLUS NIGER FROM ALLIUM CEPA
Biotransformation is a biological process in which the microbes are converting one form of compound to the another form. In the present research work, we studied about the conversion of Quercetinto kaempferol, which is having more therapeutic potential. Flavonoids are diverse group of secondary metabolites found especially in all plants. Flavonoids have Anti-carcinogenic, Anti-inflammatory, antiox...
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