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IN-VITRO SEED GERMINATION AND EFFECT OF TDZ AND AgNO3 ON HIGH FRE-QUENCY SHOOT REGENERATION FROM RUELLIA TUBEROSA L., USING COTYLE-DANARY NODE EXPLANTS
Ruellia tuberosa, commonly called Minnie root, has plenty of applications in herbal medicine due to the presence of several bioactive compounds. A simple, efficient, and reproducible in-vitro plant regeneration protocol was developed for Ruellia tuberosa. The cotyledonary nodal explants were excised from seedlings were inoculated on Murashige and Skoog (MS) medium supplemented with various concent...
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USE OF ELECTRON MICROSCOPY IN STUDY OF STEROIDOGENIC CELLS OF NORMAL, REGRESSING AND PREGNANT CAPRINE CORPORA LUTEA
Electron microscopic studies revealed variations in different cell organelles in steroidogenic cells of normal, regressing and pregnant caprine corpora lutea. Corpus luteum was comprised of two types of steroidogenic cells viz. small theca luteal cells and large granulosa luteal cells. In granulosa luteal cells, rough endoplasmic reticulum was most abundant in corpus luteum of pregnancy. The numbe...
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COMMUNITY PHARMACISTS’ PERCEPTION AND EXPERIENCE IN PROVIDING LIFESTYLE ASSISTANCE TO PATIENTS WITH CARDIOVASCULAR DISEASE
Background: Cardiovascular disease (CVD) is the leading cause of death worldwide. Management of behavioral risk factors is recommended for primary and secondary prevention of CVDs. There is evidence that the involvement of community pharmacies in health promotion activities is successful. Objectives: This study was conducted to assess community pharmacists’ perception and current practice in pro...
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ANTIOXIDANT PROPERTIES OF INDIAN MEDICINAL PLANTS IN THE REGION OF MAHARASHTRA AND TAMIL NADU: A REVIEW
India is the peninsula of the herbal hub, in which the ayurvedic system of medicine has flourished as enlightenment in the field of medicine. Plants had played a vital role since ancient times when people used plant derivatives as a source of the drug. Currently, some spices and medicinal plants have become the preponderant source of drug discovery in research for treating diverse forms of the dis...
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FORMULATION AND EVALUATION OF CARBAMAZEPINE BILAYER TABLET FOR BIMODAL RELEASE
Carbamazepine (CBZ) has long been a therapeutic option for bipolar disorder. Carbamazepine is used to treat acute manic and mixed episodes associated with bipolar I disorder. In the present study, bilayer tablet was developed to improve dosing convenience and decrease daily fluctuations in serum CBZ concentration, thereby lowering the incidence of adverse events. In bilayer tablet one layer prov...
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GREEN SYNTHESIS OF NANOPARTICLES: A BRIEF STUDY
Nanoparticles are small particles ranging from 1 to 100 nanometers. The biological production of nanoparticles is cheaper than chemical production. Besides being cheaper, it is eco-friendly as well. This biological procedure is a bottom-up procedure where the extracts of natural products replace the chemical reducing agents. These reducing and stabilizing agents are found in plants and can be used...
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APPLICATION OF VALIDATED LC-MS/MS METHOD FOR THE QUANTIFICATION OF LENVATINIB IN BIOLOGICAL MATRICES: SUPPORTING IN-VIVO BIOAVAILABILITY STUDIES IN HEALTHY RABBITS
A sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) technique was developed and validated for the quantification of lenvatinib in plasma samples. Plasma samples were presented by selecting the Liquid-Liquid extraction (LLE) method with ethyl acetate. The technique was developed and validated with respect to the parameters specificity, sensitivity, carry-over, recovery, precision,...
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FORMULATION AND EVALUATION OF NABUMETONE LOADED TRANSFERSOMAL GEL
Nabumetone (NBT), a non-steroidal anti-inflammatory drug used to treat rheumatoid arthritis, is rapidly metabolized in the liver and is well known for its side effects along with its sensitivity to light; thus, it limits the formulation of a such drug when considered for skin formulations. Recently introduced a new type of carrier for bioavailability benefits and patient compliance, the “transfe...
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TARGET TREATMENT IN DIABETIC AND MICROVASCULAR COMPLICATIONS: AN UPDATED REVIEW
Diabetes Mellitus is the most common endocrine disorder, affecting a larger population of the world, which arises due to defective insulin secretion by beta cells in the pancreas or insulin resistance by peripheral tissues. As the disease progress, microvascular complications like nephropathy, neuropathy, retinopathy, and cardiovascular complications are observed, which the leading causes of death...
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SYNTHESIS AND CHARACTERIZATION OF NOVEL PYRIMIDINE-4,5-DIAMINE/ PYRIMIDINE-2,4,5-TRIAMINE AS ANTITB AGENT
Pyrimidine derivative had a wide range of biological activities, including antiTB activity. In this view, pyrimidine moiety containing N N5-(3-substituted benzylidene)-N4-phenyl and N5-(2-substituted benzylidene)-N2,N2-dimethyl-N4-phenyl compounds was designed, and a novel series of N5-(3-substituted benzylidene)-N4-phenyl pyrimidine-4,5-diamine [5A-5F]/N5-(2-substituted benzylidene)-N2,N2-dimethy...
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