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QUALITY BY DESIGN (QBD) APPROACH TO DEVELOP STABILITY-INDICATING RP-HPLC METHOD DEVELOPMENT FOR PIOGLITAZONE AND GLIMEPIRIDE
Background and Objectives: A sper requisition of current regulatory requirements, a simple, rapid, and sensitive method by 33 factorial QbD approach was established and validated for Pioglitazone (PGZ) Glimepiride (GPR) by RP-HPLC. Method: A simple RP-HPLC method has been developed and validated with different parameters such as linearity, precision, repeatability, LOD, LOQ, accuracy as per Intern...
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FORMULATION, OPTIMIZATION AND EVALUATION OF HEXADECANOIC ACID PHYTOSOMAL GEL FOR ANTI-FUNGAL ACTIVITY
Phytosomes is vesicular drug delivery system in which phytoconstituents of herb extract surround and are bound by lipid. Hexadecanoic acid is the phytoconstituents of Nigella sativa oil. Hexadecanoic acid is hydrophobic and possesses less solubility and permeability. The study aims to formulate, optimize, and evaluation of hexadecanoic acid phytosomal gel for anti-fungal activity hexadecanoic acid...
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ANTI-PROLIFERATIVE AND APOPTOSIS INDUCING EFFECT OF NARAVELIA ZEYLANICA L. AGAINST LUNG CANCER CELL LINE A549
Cancer is one of the most dangerous diseases globally, and it appears due to extreme free radical damage, some chemicals, and a lack of physical activity which dispute causes damage to the cellular DNA, protein, and lipids. A number of treatment methods are available, but they cause unwanted side effects. The use of plant-derived products in the treatment of cancer prominently reduces adverse and ...
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DNA CLEAVAGE STUDIES OF SOME COMPLEXES OF SCHIFF BASE PYRIMIDINE ONE DERIVATIVES
A series of metal complexes, namely, Ni (II), Zn (II), Cu (II) and Pt (II), have been synthesized with newly prepared biologically active ligands. These ligands and their functional groups were carefully designed and selected to display DNA cleavage effect. Schiff base compoundof 2 - methyl - 3 - aminobenzopyrimidine - 4 - one (L1) was prepared by condensation of an equimolar mixture of 2-methyl-3...
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COMPREHENSIVE REVIEW ON ORPHAN DRUG REGULATIONS IN THE USA, EU, JAPAN, AND AUSTRALIA: POSSIBLE RECOMMENDATIONS TO SPECIFIC CHALLENGES
Orphan drugs are medicinal products intended to diagnose, prevent, or treat life-threatening or debilitating rare diseases. In some parts of the world, a rare disease is also addressed as an orphan disease due to its poor diagnosis mechanism, low prevalence, and limited treatment options. The United States, Japan, Australia, and the European Union have adopted policies promoting orphan drugs devel...
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ANTIMICROBIAL ACTIVITY OF HYDRO-ALCOHOLIC BARK EXTRACT OF PONGAMIA PINNATA
Kanuga (Pongamia pinnata), a plant belonging to Leguminosae described in Vedas has ethnobotanical importance and a variety of medicinal properties. Pongamia pinnata, commonly grown on the roads of India is used to heal wounds, treat many fungal infections, skin diseases and to clean teeth. The objective of the current study is to perform phytochemical analysis and appraise the antimicrobial activi...
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COVID-19 PANDEMIC-A FORTUNATE SCENARIO FOR PHARMACEUTICAL SCIENTISTS
Covid-2019: The pandemic that shook the entire world. There is no sarcasm if one says there will be a Pre and Post- COVID-19 world. Worldwide, millions of cases have been identified, and heaps have died. So many nations worldwide have issued a lockdown to stop the coronavirus's unfolding, which triggered giant financial fallout. Like each and every incident has two dimensions, Covid-19 possesses b...
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THE MYSTERY AND HISTORY OF ALZHEIMER’S DISEASE
Even though the malady of dementia has existed for thousands of years, the correlated neurodegenerative alterations taking place in certain regions of the human brain were detected in recent times. Today, we are aware that dementia is a primary manifestation of Alzheimer’s disease (AD). In 1907, Alöis Alzheimer described the symptoms of a 51-year-old woman, Auguste Deter, who was under his obse...
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ISOLATION, CHARACTERIZATION AND PHYTOCHEMICAL EVALUATION OF ACTIVE COMPOUND THYMOL FROM CYCLEA PELTATA LAM
Cyclea peltata (Lam), belonging to the family Menispermaceae, is a common plant in South India. It is mentioned in Ayurvedic classics by Rajapatha and is one of the important drugs used in Ayurveda therapeutics and is used widely in different formulations in medical practice. The quality control of crude herbal drugs and their bio constituents is paramount in justifying their acceptability. The cr...
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IMPROVED BIOAVAILABILITY OF LINAGLIPTIN BY RESVERATROL IN RATS- INVOLVEMENT OF PERMEABILITY GLYCOPROTEIN (P-gp) INHIBITION
The maintenance of an appropriate serum concentration of a drug is important to ensure therapeutic efficacy. Functional alterations of drug transporters may influence the serum concentration of drugs through changes in its pharmacokinetics and pharmacodynamics (PK/PD). In this study, we have focused on the influence of functional alterations in the intestinal P-glycoprotein (P-gp) on the PK of lin...
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