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DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC METHOD FOR THE ESTIMATION OF SOFOSBUVIR
A simple stability-indicating high-performance thin-layer chromatographic method which is economic, selective, and precise for analysis of Sofosbuvir (SFB), both as a bulk drug and in formulations, was developed and validated according to ICH guidelines. The method employed HPTLC precoated Merck TLC plates RP-18 F254 as the stationary phase while the solvent system prepared by mixing n-Hexane: Eth...
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A REVIEW ON THE MITOCHONDRIAL DYSFUNCTION IN SPORADIC PARKINSON’S DISEASE
Parkinson’s disease is the second most common progressive, age-linked neurodegenerative disorder. The sporadic form of the disease is usually idiopathic, where mitochondrial dysfunction is its major hallmark. Mitochondria are multifunctional dynamic organelles that carry out major cellular functions that get damaged by reactive oxygen species, deposition of lewy bodies, dopaminergic neuronal cel...
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ANTI-INFLAMMATORY, ANALGESIC AND ANTIMICROBIAL ACTIVITIES OF SOME SYNTHETIC FURANONES AND THEIR PYRROLONE DERIVATIVES
In the present study, 3-naphthoyl propionic acid and various appropriate reagents were used to synthesize, ten new synthetic furanone derivatives, i.e. 3-arylidene-5-(naphthalen-2-yl) furan-2(3H)-one (2-11). Selected furanones were made to react with ammonia and benzylamine to yield analogous pyrrolones (12-16) and N-benzyl pyrrolones (17-21), respectively, which were characterized on the basis of...
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DESIGN AND EVALUATION OF CHRONOTHERAPEUTIC ANTI-HYPERTENSIVE COMBINATION THERAPY USING MINI-TABLETS TECHNOLOGY
Hypertension or elevated blood pressure (BP) is a serious medical condition that significantly increases the risks of heart, kidney, brain, and other diseases. In persons with normal BP and uncomplicated essential hypertension, BP falls to the lowest levels during the nighttime sleep, and rises suddenly with morning awakening, and reaches the peak during the initial h of diurnal activity. The opti...
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CHARACTERIZATION AND PHARMACODYNAMIC EVALUATION OF DEVELOPED MICROEMULSION FOR NASAL DRUG DELIVERY
In the present study, we had developed Asenapine maleate (ASNM) loaded microemulsion (ME) to increase the solubility of Asenapine maleate by components of microemulsion including formulation concern, characterization, mucosal diffusion, stability and nasal ciliotoxicity of Asenapine maleate microemulsion (AME). For nasal delivery of Asenapine maleate, a challenge existing in formulation developmen...
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CHEMICAL COMPOSITION AND ANTIMICROBIAL PROPERTIES OF DIFFERENT BASIL OILS
The aerial parts essential oils of Ocimum basilicum (Lamiaceae) from Togo were steam-distilled and investigated for their percentage composition (GC and GC/MS) and in vitro antimicrobial activities. Five oil chemotypes were identified and classified as follows in line with their principal components: estragole type; linalool/estragole type; methyleugenol type; methyleugenol/t-anethole type; taneth...
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TOXICITY EVALUATION AND BEHAVIOURAL CHANGES OF LABEO ROHITA EXPOSED TO ETHION 50% EC
Modernization and intensification of agricultural production is generally accompanied by a rapid increase in the use of chemical fertilizers and pesticides. Ethion 50% EC is a broad-spectrum organophosphate insecticide used to control insects, mites, and nematodes by soil, foliar, and seed treatment applications, mainly on potatoes, sugar beet, rice, and maize, citrus. The aim of the present study...
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FABRICATION AND EVALUATION OF ELASTOSOMES OF BOSWELLIA SERRATA FOR TRANSDERMAL DRUG DELIVERY
The extracts of Boswellia serrata possess notable medicinal uses. Boswellia serrata is a highly lipophilic drug. It undergoes extensive hepatic first-pass metabolism. The t1/2 is approximately 6 h. There are reported side effects with the administration of Boswellia serrata. This research work aims to fabricate Elastosomes which get hold of many desired features for transdermal drug delivery. The ...
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DEVELOPMENT AND EVALUATION OF POMALIDOMIDE SUPERSATURABLE SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM FOR IMPROVED SOLUBILITY AND DISSOLUTION RATE
Background: Pomalidomide belongs to BCS class IV drug with low solubility and undergoes first-pass metabolism leads to reduced bioavailability of 15%. Objective: The current study aimed to develop pomalidomide Super saturable-SNEDDS to enhance solubility. Methods: Preliminary solubility studies were performed to identify oil, surfactant, and co-surfactant ratios. Pseudo tertiary phase diagram cons...
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IN-VITRO ANTIBACTERIAL ACTIVITIES OF EXTRACTS OF YEMENI PLANTS MYRTUS COMMUNIS L. AND FLEMINGIA GRAHAMIANA WIGHT & ARN.
Yemen is located on the southwestern brink of the Arabian Peninsula. The methanolic and aqueous crude extracts of two Yemeni traditional medicinal plants Myrtus communis L. and Flemingia grahamiana Wight & Arn were evaluated for antibacterial activity in-vitro by Well- diffusion method against six bacterial pathogens, Staphylococcus aureus, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella...
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