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DRUG UTILISATION STUDY OF ANTI-EPILEPTIC DRUGS IN PEDIATRIC PATIENTS IN A TERTIARY CARE HOSPITAL
Few studies are available to study the drug utilization pattern and adverse drug reactions of anti-epileptic drugs (AEDs) in paediatric population. Hence, this study was planned with the primary objective of studying the drug utilization pattern of anti-epileptic drugs in a tertiary care centre pediatric population. The secondary objective was to assess adverse drug reactions in the same populatio...
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ANTICARIOGENIC ACTIVITY OF GALLS OF QUERCUS INFECTORIA OLIVIER AGAINST ORAL PATHOGENS CAUSING DENTAL CARIES
In this study, attempts were made to evaluate the anti-microbial activity of the galls of Quercus infectoria Olivier against oral bacteria causing dental caries. Various solvents systems were used to screen the potential of the extract on the clinically isolated organism and reference strains; Candida albicans MTCC 183, Streptococcus mutans MTCC 497, Lactobacillus acidophilus MTCC 10307 and Staphy...
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DESIGN, DEVELOPMENT AND CHARACTERIZATION OF FAST DISINTEGRATING TABLET OF AMLODIPINE BESYLATE BY USING SUPERDISINTEGRANTS PLANTAGO OVATA AND LOCUST BEAN GUM
The objective of the present study was to develop and characterize the fast disintegrating tablets, which rapidly disintegrates in the sublingual area without the need of water or with a little amount of water. Amlodipine besylate is a calcium channel blocker (long-acting) basically used in the treatment of angina and hypertension for immediate relief in life-threatening conditions. In this work, ...
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A REVIEW ON WOUND AND ADVANCEMENT IN HEALING STRATEGIES
Wound healing is a complex and dynamic physiological process that occurs by a sequence of interrelated molecular events that should work together in a proper manner and time to restore cellular function and tissue integrity. These physiological phases occur efficiently in normal healthy volunteers and/or under normal conditions. But, in some cases, these events are retarded, which results in hard-...
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ANTIOXIDANT ACTIVITY OF CASSIA AURICULATA AND CASSIA FISTULA EXTRACT ALONG WITH WOUND HEALING ACTIVITY OF ITS POLYHERBAL FORMULATION
Due to emergent concerns about unhealthy consequences of chemicals in the health industry, the interest towards natural and herbal substances has been growing every day. In this study, the antioxidant effect of Cassia fistula [CFF] and Cassia auriculata [CAF] extract was evaluated. Also discover wound healing activity of polyherbal formulation (CFF and CAF). The antioxidant activity of the extract...
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A REVIEW ON DIVERSITY AND ANTIMICROBIAL METABOLITES FROM HALOPHILIC BACTERIA
Microorganisms that live their life in places with high salt concentrations are known as Halophiles. Halophilic bacteria play a majority role in hypersaline environments than other microorganisms. These Halophiles are having intense strategies of adaptation and tolerate them to sustain their survival in the saline extreme, such adaptation in hypersaline environments makes them to give unique atten...
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FORMULATION, DEVELOPMENT AND IN-VITRO EVALUATION OF HYDROGEL BASED CONTROLLED RELEASE MATRIX TABLET OF PROPRANOLOL HYDROCHLORIDE
Hypertension is the most life-threatening disease amongst all lifestyle diseases. So, there is always a need for such a dosage that can release the drug for a long period from a single dose which will reduce the dose burden for the patient. The propranolol HCL is a non-selective beta-adrenergic blocking agent extensively used in various cardiovascular diseases. In the present study hydrogel matrix...
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FORMULATION, EVALUATION AND COMPARISON OF NATURAL AND SYNTHETIC SUPERDISINTEGRANTS USED IN THE FAST-DISSOLVING TABLET BY DIRECT COMPRESSION TECHNIQUES
Fast-dissolving tablets are a novel drug delivery system that provides the fastest onset of action and rapid pharmacological effects after administration. It can be administered simply by putting the tablets on the tongue, without the need for water. Mostly, this drug delivery system is efficient in emergency situations where an immediate drug response is needed. For the formulation of this kind o...
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BREAD FRUIT LEAF EXTRACT COMPOSITION AND ITS EFFECT ON OXALATE AND LEUKOCYTE PROFILES IN HYPEROXALURIC RATS INDUCED BY ETHYLENE GLYCOL
Nephrolithiasis or kidney stone disease is a disease characterized by the formation of crystals in the kidney. It is a disease that is found in many countries with high rates of recurrence and treatment costs. This study analyzes the effect of Breadfruit leaf extract on oxalate levels of CaOx stones deposited in the kidney and leukocyte differentiation in hyper oxaluric rats induced ethylene glyco...
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QUALITY BY DESIGN (QBD) APPROACH TO DEVELOP STABILITY-INDICATING RP-HPLC METHOD DEVELOPMENT FOR PIOGLITAZONE AND GLIMEPIRIDE
Background and Objectives: A sper requisition of current regulatory requirements, a simple, rapid, and sensitive method by 33 factorial QbD approach was established and validated for Pioglitazone (PGZ) Glimepiride (GPR) by RP-HPLC. Method: A simple RP-HPLC method has been developed and validated with different parameters such as linearity, precision, repeatability, LOD, LOQ, accuracy as per Intern...
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