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FABRICATION AND CHARACTERIZATION OF METFORMIN HYDROCHLORIDE LOADED MICROSPHERES BY INCORPORATING NATURAL AND SYNTHETIC POLYMERS FOR COMPARATIVE ANALYSIS
The present developed method was designed to fabricate an innovative, simple, cost-effective, and compatible method for controlled delivery of Metformin hydrochloride (MF) by the use of natural and synthetic polymers for comparative analysis. For the most commonly used anti-diabetic drug Metformin hydrochloride, we have tried to formulate microspheres by incorporating natural and synthetic polymer...
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DEVELOPMENT AND VALIDATION OF NITECAPONE IN HUMAN PLASMA USING TOLCAPONE AS INTERNAL STANDARD BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY
The present LC-MS/MS method for estimation of Nitecapone in human plasma using Tolcapone as an internal standard is established and validated as per FDA guidelines. A good response was obtained with ZORBAX Eclipse plus C18 column (150 mm × 4.6 mm ID, 5 μm) and mobile phase with a mixture of 0.01 M Ammonium phosphate buffer with pH adjusted to 5.0 with OPA and Acetonitrile (70:30, v/v) at a flow ...
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EXPLORATION OF INDIAN SARSAPARILLA HEMIDESMUS INDICUS (L.)
From the primordial times' plants are standard as a chief resource for mankind. In the traditional system of medicine, Indian sarsaparilla Hemidesmus indicus (Family Asclepiadaceae) is a commonly well-known medicinal plant. This plant contains various phytoconstituents belonging to flavonoids, tannins, glycoside, sterols, and volatile oil. In the traditional system, the plant Hemidesmus indicus is...
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SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF ANAGLIPTIN AND METFORMIN HCL BY SECOND DERIVATIVE METHOD
A Simple, accurate, and precise spectrophotometric method (1st order derivative method) was developed and validated for the estimation of Anagliptin and Metformin HCl in synthetic mixture. In this method, Anagliptin was estimated at 244 nm where Metformin HCl showed zero absorbance. Metformin HCl is estimated at 234 nm at which Anagliptin showed zero absorbance. The method was linear over the conc...
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ALLEVIATION EFFECT OF VENTILAGO CALYCULATA AGAINST DEXAMETHASONE DELAYED WOUND HEALING
Suppression of wound repair is a challenge for patients and healthcare workers globally. Excision and incision wounds were created on Wistar albino rats on the back of the experimental animals. The rats were categorized into seven groups (n = 6). The study aimed to determine the effect of topical administration of successive extracts of Ventilago calyculata (stem bark) against dexamethasone-suppre...
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A SENSITIVE LC-MS/MS ASSAY FOR THE DETERMINATION OF NAFTOPIDIL IN HUMAN PLASMA AND ITS APPLICATION TO A PHARMACOKINETIC STUDY
A specific, rapid, and sensitive LC-MS/MS assay was developed and validated for the determination of Naftopidil in human plasma. Naftopidil d7 was used as an internal standard (IS). A faster and one-step protein precipitation (PP) technique was employed for sample preparation. The processed samples were chromatographed on a C18 column using ammonium formate (5mM) buffer in combination with acetoni...
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GC-MS ANALYSIS AND IN-VITRO CYTOTOXICITY STUDY OF DENDROPHTHOE FALCATA AND TRIDAX PROCUMBENS EXTRACTS AGAINST HACAT CELLS LINE
The present study shows the cytotoxic effect of Dendrophthoe falcata (L. f) and Tridax procumbens Linn. extracts against HaCat (Skin cancer) cell line by MTT and SRB assay method. The phytochemical screening of extracts dichloromethane: methanol (DM), methanol: water (MW), and ethanol: water (EW) revealed the presence of secondary metabolites such as alkaloids, flavonoids, saponins, tannins, stero...
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LOOKING FROM PAST TO PRESENT- CHAKSHUSHYA DRUGS IN BHAVAPRAKSHA NIGHANTU AND RESEARCH DONE ON THEM
Bhavaprakasha is unique in the sense that it shows the slow amalgamation of traditional Indian materiamedica with several new additions which came to the Indian subcontinent through trade and exchanges with foreign civilizations. The Nighantuportion of Bhavaprakasha is an excellent repertoire of herbs and minerals used in Ayurveda. Several plants with properties related to augmentation of ocular f...
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A REVIEW ON REGULATORY FRAMEWORK OF RADIOPHARMACEUTICALS IN PHARMACEUTICAL INDUSTRY: CURRENT SCENARIO AND FUTURE ASPECTS
In recent times, the use of radiopharmaceuticals in Medical Imaging and Nuclear medicine has increased. They are a special group of pharmaceuticals with short-shelf life in their final state, and their preparation has been done with utmost care. Due to the inherently hazardous nature of radionuclides on the one hand and the associated concern about radiation safety for patients and staff handling ...
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EVALUATION OF CORRELATION BETWEEN GLYCATED HEMOGLOBIN AND HEMATOLOGICAL INDICES IN TYPE 2 DIABETES MELLITUS PATIENTS
Diabetes Mellitus increases the risk of both microvascular and macrovascular complications, out of which CVD affects approximately 32.2% of people with Type 2 Diabetes Mellitus globally. It is predicted that for every 1% increase in HbA1c is associated with a 30% increase in all-cause mortality and a 40% increase in CVD mortality in T2DM patients. This study aims to evaluate the correlation of Hb...
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