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RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF LORNOXICAM AND EPERISONE HYDROCHLORIDE
Several spectrophotometric and HPLC methods for the determination of lornoxicam and eperisone hydrochloride have been documented individually or in combination with other drugs in pharmaceutical dosage forms. Therefore, in the present study, a reasonable and practical reverse phase HPLC method was developed and validated for lornoxicam and eperisone hydro-chloride in bulk formulation. In RP-HPLC ...
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REGULATION OF RAS-INDUCED HYPHAL FORMATION BY HISTONE ACETYLASE GCN5 IN CANDIDA ALBICANS
Candida albicans is the leading cause of superficial and systemic fungal infections in human beings and is very common in people with a weakened immune system. It can grow either as budding yeast, a pseudohyphae form, or in a true hyphal form, and the ability to switch between these three forms is important for its pathogenicity. To date, an in-depth study on the relationship between histone modif...
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AN OVERVIEW: MEDICINALLY IMPORTANT HETEROCYCLIC MOIETY BENZOTRIAZOLE
In organic chemistry, the largest families of organic compounds belong in the heterocyclic compounds. In our daily life, the importance of heterocyclic compounds is very essential. It has a broad range of applications in medicinal chemistry. Benzotriazole is a bicyclic heterocyclic system consisting of three nitrogen atoms and a fused benzene ring, shows wide range of biological and pharmacologica...
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EVALUATION OF ANTIOXIDANT ACTIVITY AND QUANTIFICATION OF α–ASARONE IN RHIZOMES OF ACORUS CALAMUS L. USING HPTLC FINGERPRINTING
This study aimed to analyze antioxidant activity and quantify alpha-asarone by using High-performance thin-layer chromatography (HPTLC). Alpha-asarone is a secondary metabolite in hydroalcoholic (1:1) rhizome extracts of Acorus calamus L. (AC), a medicinal plant being used around the globe traditionally. Sweet flag, AC is a member of the Acoraceae family, and is commonly used unaided as well as in...
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IN-VITRO EVALUATION OF BIOACTIVE COMPOUNDS FROM FIVE DIFFERENT MEDICINAL PLANTS
The forest of India is the principal repository of a large number of medicinal and aromatic plants; they are the richest source of bioactive compounds, which are largely collected as raw materials for the manufacture of drugs and perfumery products. The present study deals with five different medicinal plants viz., Polyalthia longifolia, Anonna muricata, Elephendopus scaber, Senna alata, and Hypti...
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IN-VIVO AND IN-VITRO ANTIASTHMATIC STUDIES OF PLANT MICHELIA CHAMPACA LINN.
Michelia champaca known as champaca is belonging to family of Magnoliaceae. The present work consist of extraction and evaluation of anti-asthmatic activity of flowers of Michelia champaca Linn. Flowers was evaluated for anti-histaminic activity using isolated goat tracheal chain preparation and histamine induced Broncho-constriction in Albino mice. Michelia champaca Linn. expressively inhibited d...
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EVALUATION OF ANTIMICROBIAL ACTIVITY OF SESUVIUM PORTULACASTRUM (L.) L. AND EXCOECARIA AGALLOCHA L.
Background: Sesuvium portulacastrum L. and Excoecaria agallocha (L.) are two important medicinal plants inhabited in mangrove regions. Early researches focused on antimicrobial activity of leaves of concerned plants with various solvents among which ethanol, chloroform, and methanol were the best Objective: In the present study the extracts of two therapeutic plants were researched to measure the ...
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548
TECHNOLOGICAL DEVELOPMENT IN COMPARISON WITH IDEAL FORMULATION OF BCS CLASS IV DRUG – RIFAXIMIN
The solubility, dissolution, and gastrointestinal permeability are the prime factors for drug absorption. Rifaximin is a structural analogue of rifamycin that inhibits RNA synthesis by binding to β-subunit of bacterial DNA-dependent RNA polymerase. Rifaximin is a class 1V drug having low solubility and low permeability. My theme of the design is to develop the technological characterization of do...
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ANTIBIOTICS SUSCEPTIBILITY IN CHRONIC SUPPURATIVE OTITIS MEDIA (CSOM) AT THE SECONDARY CARE HOSPITAL IN NORTH INDIA
Background: Chronic suppurative otitis media (CSOM) is defined as a persistent infection of the middle ear cleft with a perforated tympanic membrane and draining exudate for more than 6weeks. Information about the organism responsible for COSM and their antibiotic susceptibility is important for effective treatment. Material and Methods: A prospective cross-sectional study was conducted on 85 pati...
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A BRIEF REVIEW ON HIBISCUS SABDARIFFA LINN WITH THEIR MEDICINAL USES AND PHARMACOLOGICAL ACTIVITY
Hibiscus sabdariffa Linn is a medicinal plant commonly known as Rosella, Sorrel, Jamaica, red-Ambadi, Queensland jelly plant etc. belonging to the family Malvaceae. Since ancient times, it has played an important role in treating various diseases. It enlarges great importance for its therapeutic potential. It is native to India, tropical Africa, and many countries like Brazil, Australia, Hawaii, F...
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