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DESIGN CHARACTERIZATION AND FORMULATION OF IN-SITU GELLING OPHTHAL-MIC DRUG DELIVERY SYSTEM CONTAINING PLANT DERIVED PHENOLS
The objective of the present investigation was to formulate and evaluate ion-activated in-situ gel using the herbal drug catechin, a potential natural antioxidant for the treatment of glaucoma by lowering oxidative stress. A total of eight formulations were prepared and evaluated for parameters, namely physical appearance, gelling capacity, pH measurement, rheological studies, the effect of steril...
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DEVELOPMENT AND STANDARDIZATION OF STABILITY INDICATING UV-SPECTROPHOTOMETRIC METHOD FOR ASSESSMENT OF BILASTINE IN BULK AND PHARMACEUTICAL DOSAGE FORMULATION
The objective of the present work is to develop and standardize the UV-Spectrophotometric method for the assessment of Bilastine in bulk and pharmaceutical dosage forms. On account of not much work being reported on the drug Bilastine and also it is a new second-generation anti-histamine molecule. Hence it is necessary in this context to relook into the older methods and further research for new...
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IMPROVEMENT IN BIOAVAILABILITY OF OXCARBAZEPINE USING SPHERICAL AGGLOMERATION
Spherical agglomeration technique enables simultaneous crystallization and agglomeration. Oxcarbazepine spherical agglomerates were prepared by crystallo-co agglomeration technique. Acetone acted as a good solvent, aqueous solution of PEG 6000 served as a bad solvent, and dichloromethane was used as bridging liquid. The optimization was carried out using 23 factorial design, where the factors were...
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SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME NOVEL 1, 2, 3, 4-TETRAHYDROQUINAZOLINONE DERIVATIVES
In the study, we have successfully synthesized N-3 substituted tetrahydroquinazolinone by the reaction of isotonic anhydride with aniline derivatives. Thereafter novel derivative would be subjected to synthesize (1, 2, 3, 4-tetrahydroquinazoline) by Mannich reaction with ciprofloxacin and norfloxacin. These synthesized compounds (2a, 2b, 2c, 2d, 2e, 2f, 2g, and 2h) were characterized by FT-IR, 1H ...
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GREEN SYNTHESIS OF SILVER NANOPARTICLES USING SAUROPUS ANDROGYNOUS LEAF EXTRACT WITH POTENTIAL BIOLOGICAL PROPERTIES
Nanoparticles are being constantly exploited by the scientific community due to their versatile properties and applications. However, the synthesis of metallic nanoparticles achieved through conventional physical and chemical techniques is quite expensive and a labor-intensive process with serious consequences like instability of nanoparticles and toxic byproducts. Hence, green synthesis utilizing...
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DESIGN, DEVELOPMENT AND EVALUATION OF GASTRIC FLOATING IN-SITU GEL OF PIROXICAM
The present study involves the formulation and evaluation of floating in-situ gel containing piroxicam for the treatment of arthritis. In the FTIR and DSC study for compatibility of piroxicam with polymers, there are no significant changes observed so it is confirmed the absence of drug-polymer interactions. The gastric floating in-situ gel was prepared by using Sodium Alginate, HPMC K 200 M &...
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ISOLATION AND STRUCTURAL ELUCIDATION OF IMPURITY IN NEBIVOLOL
In the synthesis of Nebivolol [a mixture of (1RS, 1' RS)-1,1'-{(2RS, 2' SR)-bis(6-fluoro 3, 4-dihydro-2H-1-benzopyran-2-yl)} -2,2'-iminodiethanol] having four chiral centers, one crucial isomeric impurity at 0.88 RRT was observed in HPLC related substance analysis in gradient HPLC method. This impurity was isolated from synthesized crude impurity substance by preparative HPLC with chiral normal ph...
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EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF TILIACORA ACUMINATA EXTRACT IN RATS
Inflammation is part of the body's immune response. There can be four primary indicators of inflammation: pain, redness, heat or warmness and swelling. Plants have the ability to synthesize a wide verity of phytochemical compounds as secondary metabolites which shows anti-inflammatory activity. The anti-inflammatory activity of ethanol extract of Tiliacora acuminata stem and leaf was evaluated usi...
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PHARMACOLOGICAL EVALUATION OF POLYHERBAL SUSPENSION FOR ANTI-PARKINSONS ACTIVITY IN ALBINO RAT
The ethanolic extract of Terminalia chebula extract obtained from successive extraction of Rosa damascene by Methanol; n-hexane & n-butanol was subjected to various phytochemical tests. The antioxidant activity was accessed by DPPH method. The anti-Parkinson’s activity was tested in albino Rats. Thirty albino rats (180-250 g) of either sex were divided into five groups and each group consist...
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FORMULATION AND EVALUATION OF BIOADHESIVE BUCCAL TABLETS OF ENALAPRIL MALEATE
Enalapril maleate competitively inhibits the ACE to hinder the production of angiotensin II, a key component of the rennin angiotensin aldosterone system that promotes vasoconstriction and reabsorption of sodium ion in the kidney, overall decrease in blood pressure. The study's main objective was to formulate and evaluate bioadhesive buccal tablets to avoid the first-pass metabolism in the liver a...
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