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DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROSCOPIC METHOD FOR SIMULTANEOUS ESTIMATION OF MANGIFERIN AND BERBERIN HCL IN BULK AND SYNTHETIC MIXTURE
Introduction: There are so many promising plant-based chemical constituents are present which act as an alternative therapy for the control of diabetes. But due to the lack of its proper quality control parameters, they are not widely used. The USFDA patent is approved for a fixed dosage combination of Mangiferin (MF) and Berberin HCl (BER) as antidiabetic herbal formulation. Objective: The litera...
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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION STUDIES FOR THE ESTIMATION OF NIMESULIDE AND DICYCLOMINE HYDROCHLORIDE IN FIXED DOSE COMBINATION TABLETS
A simple, accurate, and precise reversed-phase high-pressure liquid chromatography (RP-HPLC) method was developed for the simultaneous estimation of nimesulide and dicyclomine hydro-chloride in fixed-dose combination tablets. The developed method was validated as per ICH guidelines Q2(R1). The chromatographic separation was achieved on Hypersil ODS C18 (200 × 4.6 mm 5 μ) column using methanol: p...
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DESIGN AND EVALUATION OF CHRONOTHERAPEUTIC ANTI-HYPERTENSIVE COMBINATION THERAPY USING MINI-TABLETS TECHNOLOGY
Hypertension or elevated blood pressure (BP) is a serious medical condition that significantly increases the risks of heart, kidney, brain, and other diseases. In persons with normal BP and uncomplicated essential hypertension, BP falls to the lowest levels during the nighttime sleep, and rises suddenly with morning awakening, and reaches the peak during the initial h of diurnal activity. The opti...
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ANTIOXIDANT ACTIVITY OF CASSIA AURICULATA AND CASSIA FISTULA EXTRACT ALONG WITH WOUND HEALING ACTIVITY OF ITS POLYHERBAL FORMULATION
Due to emergent concerns about unhealthy consequences of chemicals in the health industry, the interest towards natural and herbal substances has been growing every day. In this study, the antioxidant effect of Cassia fistula [CFF] and Cassia auriculata [CAF] extract was evaluated. Also discover wound healing activity of polyherbal formulation (CFF and CAF). The antioxidant activity of the extract...
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A REVIEW ON WOUND AND ADVANCEMENT IN HEALING STRATEGIES
Wound healing is a complex and dynamic physiological process that occurs by a sequence of interrelated molecular events that should work together in a proper manner and time to restore cellular function and tissue integrity. These physiological phases occur efficiently in normal healthy volunteers and/or under normal conditions. But, in some cases, these events are retarded, which results in hard-...
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PHYTOCHEMICAL SCREENING, ANTIBACTERIAL AND ANTIOXIDANT POTENTIAL OF EXTRACTS OF MYRICA ESCULENTA LEAVES IN DIFFERENT SOLVENTS
Myrica esculenta Buch - Ham. ex D. Don has been used worldwide for the treatment of various ailments. The present work is an attempt to relate the presence of phytochemicals in leaves of M. esculenta with its antibacterial potential using seven different solvents for preparation of extracts. The preliminary phytochemical screening confirmed the presence of alkaloids, flavonoids, carbohydrates, tan...
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ANTIHYPERGLYCEMIC POTENTIAL OF TEAK SEEDS IN ALLOXAN INDUCED DIABETIC RATS
Tectona grandis is famous as a valuable timber hold an extensive range of applications around the sphere. In addition to its enormous uses in the timber industry, all the parts are cherishing with extensive use in traditional medicine and possess significant pharmacological properties. In search of drugs for diabetes, the methanolic seed extract which is prepared by the Soxhlet apparatus, was used...
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EFFECT OF ALFUZOSIN ON ETHYLENE GLYCOL AND AMMONIUM CHLORIDE INDUCED UROLITHIASIS IN MALE RATS
Urolithiasis is the most prevalent urinary tract disorder in males. Alfuzosin is a selective antagonist of post-synaptic α1a adrenoceptor, causing relaxation of smooth muscle in the bladder and prostate, which results in an improvement of urine flow and prevents ureter stones. The present study was aimed to evaluate the effectiveness of Alfuzosin on rats as a preventive and curative agent against...
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EFFECT OF VERMIWASH AND PLANT GROWTH REGULATORS ON GROWTH AND STEM ANATOMY OF HIBISCUS CANNABINUS L.
Growth and development events in plants are controlled by growth regulators and Phytohormones. These are found naturally in plants. Environmental Pollution is one of the major problems and reactions caused by artificial growth regulators and their low biodegradability has urged us to search for new biofertilizers with growth-regulating activity. Vermiwash is a liquid fertilizer that has been shown...
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DEVELOPMENT AND VALIDATION OF HPTLC METHOD FOR IDENTIFICATION AND QUANTIFICATION OF URSOLIC ACID IN THE LEAVES OF ALSTONIA SCHOLARIS
Herbs have been used since antiquity for treatment and management of various disease conditions. Their ability to cure or prevent diseases is due to storehouses of various phytoconstituents like alkaloids, flavonoids, glycosides, terpenoids, steroids, tannins, phenols, etc. present in them. Pentacyclic triterpenoids have gained greater attention of researchers due to its wide array of pharmacologi...
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