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SIMULTANEOUS DETERMINATION OF PREDNISOLONE AND ASPIRIN IN SYNTHETIC MIXTURE BY VIERORDT´s METHOD
Prednisolone (10mg/day) plus low dose Aspirin (80mg/day) improve the implantation rate in women with autoimmune condition who are undergoing in-vitro fertilization. A new, simple, precise, accurate, and validated simultaneous equation method (Vierordt´s Method) has been developed for simultaneous determination of Prednisolone and Aspirin in the synthetic mixture. The method was based on the measu...
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PHYTOCHEMICAL PROFILE AND IN-VITRO ANTIOXIDANT POTENCIES OF OROXYLUM INDICUM STEM BARK EXTRACT
Background: Phytochemical profile and antioxidant studies are based on exploring plants for their use in the development of novel therapeutic drugs. Oroxylum indicum (OI), a valuable medicinal plant is native to India, found mainly in the Himalayan foothills and the Western Ghats. It has been used by traditional medicinal practitioners for a variety of ailments and is categorized as vulnerable med...
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DESIGN, FORMULATION AND OPTIMIZATION OF RUTIN TRIHYDRATE EMULGEL BY RESPONSE SURFACE METHODOLOGY
Rutin trihydrate a herbal drug having abundant medicinal properties, mainly used for topical treatment of inflammation, presents a hindrance and reduced anti-inflammatory activity. It is BCS class II drug having low oral bioavailability, poor water solubility (0.125 g/L), and low stability of rutin in aqueous alkaline medium, restricting its application in use. So, it is successfully formulated as...
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DEVELOPMENT AND VALIDATION OF DERIVATIVE UV SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF DULOXETINE
Development and validation of a simple UV spectroscopic method for the determination of Duloxetine by the derivative spectro-photometric method is the objective of the present work. The analysis was carried out by using Shimadzu UV-1700, and Shimadzu UV-1800 UV spectrophotometer, and Acetonitrile and water (8:2) was used as solvent or mobile phase. Detection or qualitative analysis was carried out...
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VALIDATING THE PROPERTIES OF NYMPHAEA PUBESCENS WILLD. BY PERFORMING UV-VIS, TLC, FTIR AND HPLC ANALYSES
Introduction: Nymphaea pubescens Willd. is one of the well-known medicinal plants, being used from ancient times in India and commonly called “Kumuda”. It is an aquatic perennial herb. It has leaves having a smooth upper side, a strong root, and a branched rhizome. According to Bentham and Hooker classification “Genera Plantarum”, this plant belongs to the division Polypetale of Dicotyledo...
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ISOLATION AND STRUCTURAL ELUCIDATION OF IMPURITY IN NEBIVOLOL
In the synthesis of Nebivolol [a mixture of (1RS, 1' RS)-1,1'-{(2RS, 2' SR)-bis(6-fluoro 3, 4-dihydro-2H-1-benzopyran-2-yl)} -2,2'-iminodiethanol] having four chiral centers, one crucial isomeric impurity at 0.88 RRT was observed in HPLC related substance analysis in gradient HPLC method. This impurity was isolated from synthesized crude impurity substance by preparative HPLC with chiral normal ph...
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RECUPERATION OF DIABETES INDUCED OXIDATIVE DAMAGE IN LIVER BY TREATMENT WITH CURCUMIN IN STZ INDUCED DIABETIC RATS
The aim of the present study was to investigate the effect of Curcumin on blood glucose levels, body weight changes, and oxidative stress markers in the diabetic rat liver. Diabetes exacerbates hepatic injury induced by hyperglycemia mediated oxidative stress. A marked decrease in the blood glucose levels, body weight changes and anti-oxidant marker enzymes, superoxide dismutase (SOD), catalase (C...
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DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROSCOPIC METHOD FOR SIMULTANEOUS ESTIMATION OF MANGIFERIN AND BERBERIN HCL IN BULK AND SYNTHETIC MIXTURE
Introduction: There are so many promising plant-based chemical constituents are present which act as an alternative therapy for the control of diabetes. But due to the lack of its proper quality control parameters, they are not widely used. The USFDA patent is approved for a fixed dosage combination of Mangiferin (MF) and Berberin HCl (BER) as antidiabetic herbal formulation. Objective: The litera...
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LYMPHATIC TARGETING SYSTEM USING NANO-FORMULATION: CHALLENGES AND APPROACHES
The lymphatic system is the subpart of the systemic circulation for maintaining immune function; this system is mainly known as a drainage system to removes foreign bodies. This system consists of various lymphoid organs and tissues. The lymphatic system based on physiological function as absorption and micro-particulate uptake by these routes the bioavailability and efficacy were enhanced and und...
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OROXYLUM INDICUM: AN OVERVIEW
Oroxylum indicum (O. indicum), commonly known as the Indian trumpet tree, belonging to the family Bignoniaceae, is a medicinally important, small, or medium-sized plant used to treat various diseases and also has its importance in the traditional system of medicine. Various parts of the plant have been proved to possess useful pharmacological activities. It is native to the Indian subcontinent, ex...
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