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ESTIMATION OF TOTAL FLAVONOIDAL CONTENT AND NOOTROPIC ACTIVITY OF LEPIDIUM SATIVUM
Objective: Lepidium sativum (Garden cress) is traditionally an important plant with a wide range of activities from the ages. Ample literature about its biological activities, motivate us to evaluate the total flavonoids content and to screen the nootropic activity in mice. Methods: Ethanolic extract was prepared from the seeds of Lepidium sativum using ethanol (70% v/v) and total flavonoids conte...
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A PRELIMINARY IN-SILICO ANALYSIS OF OCIMUM SANCTUM FLAVONOIDS, ORIENTIN AND VICENIN-1, AS POTENTIAL DRUGS AGAINST SARS-COV-2 INFECTION
The SARS-CoV-2 virus is the causative agent of the Covid-19 pandemic. The major proteins of this virus, like covid main protease RNA dependent RNA polymerase, are being extensively studied with the hopes of finding an effective molecule that would bind to these proteins and lead to their inhibition. The inhibition of these critical viral proteins would hamper SARS-CoV-2 infection. With most of the...
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IN-VIVO PHARMACOKINETIC EVALUATION OF PIOGLITAZONE – HPMC K 15 M FLOATING TABLETS
The objective of the study is to make a pharmacokinetic evaluation of Pioglitazone floating tablets formulated employing HPMC K 15 M in comparison to Pioglitazone pure drug in rabbits. The two products were tested in a crossover RBD in healthy rabbits of either sex (n=6). The plasma concentrations of Pioglitazone were determined by a validated HPLC method. From the time versus plasma concentration...
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DEVELOPMENT, CHARACTERIZATION AND OPTIMIZATION OF KUTKI PHOSPHOLIPID COMPLEX USING CENTRAL COMPOSITE DESIGN AND RESPONSE SURFACE METHODOLOGY
Kutki (Picrorrhiza kurroa) is a medicinal herb with remarkable pharmacological properties. However, poor solubility of the active principles limits its medicinal value. This study sought to prepare kutki phospholipid complex in phospholipids such as phosphatidyl choline in order to improve its solubility and permeability. Kutki phospholipid complex (phytosome) was prepared by solvent evaporation m...
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PROBIOTICS: ANAVANT-GARDESTEP INTHE THERAPY OF RHEUMATOID ARTHRITIS
Rheumatoid arthritis (RA) is a chronic progressive inflammatory autoimmune ailment with multifactorial etiology. The human gut is a massive intricate ecosystem where microbiota, nutrients, and host cells interact extensively to uphold gut homeostasis. Gut microbiota acts as a modulator of immunity and dysbiosis has detrimental effects on health by triggering a persistent inflammatory response that...
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DIURETIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF FRAGARIA ANANASSA FRUIT IN WISTAR ALBINO RATS
Fragaria ananassa fruit are small shrubs belonging to family rosaceae. Fragaria ananassa mainly contains anti-oxidants such as tocopherols, ascorbic acid and b-carotene which are effective against cancer, heart disease and cataracts. The focus of the study was toanalyze the diuretic activity of hydro alcoholic extract of Fragaria ananassa fruit in albino rats. Diuretic activity of hydroalcoholic (...
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HISTOPATHOLOGICAL ALTERATIONS IN ALLOXAN INDUCED DIABETIC MICE LIVER AND KIDNEY AFTER CARISSA SPINARUM METHANOLIC LEAF EXTRACT TREATMENT
Carissa spinarum is an evergreen, thorny shrub found in the Himalayan areas of the Indo-Pakistan subcontinent. The plant has a number of ethnomedicinal applications. Pharmacologically this plant is used for the treatment of asthma and pulmonary diseases, anticancer, diarrhea, hepatoprotective, cardioprotective and reproductive dysfunction. The present study is aimed to study effects of Carissa spi...
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PHARMACOLOGICAL EVALUATION OF POLYHERBAL SUSPENSION AS ANTI-DEPRESSANT IN RAT
The ethanolic extract of Moringa oleifera leaves & methanolic extract of rose hips of Rosa damascena were first subjected to various phytochemical tests and further assessed for their antioxidant activity by DPPH method. Different ratio of two drugs in the polyherbal formulation were based on antioxidant activity in albino Wistar rats. Thirty rats (180 -250 g) of either sex were randomly divid...
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A STATISTICAL APPROACH TO DEVELOPMENT OF SUSTAINED RELEASE PRONIOSOMAL MICONAZOLE NITRATE GEL
Miconazole nitrate is a broad-spectrum antifungal agent, and it is used for the treatment of superficial fungal infections. It has low skin permeability. Therefore, the aim of this study was to prepare proniosomal 2% miconazole nitrate sustained release to a treat deep-seated fungal infections. The different batches of proniosomal 2% miconazole nitrate gel were prepared by the conservation phase s...
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SIMPLE SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF DRUGS AND PHARMACEUTICALS USING NBS-METHYL ORANGE DYE COUPLE
Simple, sensitive, cost-effective and selective methods are designed and developed for the oxidative indirect spectrophotometric determination of drugs and pharmaceuticals, viz., Argatrobane Monohydrate (ARG), Bortezomib (BOR), Chloroquine Phospate (CHP), Granisetron HCl (GRA), Ibandronate Sodium (IBA) based on their reactivity towards n-bromo succinamide (NBS in excess). The method is based on th...
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