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COMPREHENSIVE REVIEW ON THERAPEUTIC APPLICATIONS OF AI IN LEUKAEMIA: A MULTI-OMICS APPROACH
It is leukaemia, where immature white blood cells keep growing at a very fast pace and disrupt normal blood production. While there are many advances in treatment, genetics diversity, drug resistant and technological limits remain. Likewise, such AI combined with multi dimension approaches (genetics, transcriptomics, proteomics, metabolism, and epigenetics) has altered leukaemia research. Divining...
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DEVELOPMENT, CHARACTERIZATION AND IN-VITRO ANTIFUNGAL EVALUATION OF PLANTEROSOMAL GEL OF GANODERMA LUCIDUM
Planterosomal gel exhibit better pharmacokinetic and pharmacodynamic profile than the conventional herbal extracts. The objective of the present research work was to develop, characterize and evaluate the in-vitro antifungal activity of planterosomal gel in comparison to pure plant extract. Planterosomal gel of Ganoderma lucidum was prepared by incorporating gelling agent in planterosomal suspensi...
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MOLECULAR DOCKING AND TOXICITY STUDIES OF SERIES OF COMPOUNDS FROM DIARYL UREA HITS & SPIRO PIPERIDINE INDOLINYL SERIES AS POTENTIAL P2Y1 RECEPTOR ANTAGONISTS
Scientific investigations revealed that the study of P2Y1 receptors is very much essential in the current scenario because of their potential role in related to various disorders/diseases like thrombosis, cardiovascular problems. P2Y1 receptors belong to G protein-coupled receptors, an important target for ADP induced platelet aggregation. Blockade of P2Y1 receptors leads to the treatment of throm...
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EVALUATION OF PHYTOCHEMICAL COMPOSITION AND ANTI-OXIDANT POTENTIAL OF ANDROGRAPHIS SERPYLLIFOLIA (VAHL) WIGHT: AN ENDEMIC ANTI-OPHIDIC PLANT
In folk medicine, especially in developing countries, several plant species are employed for the treatment of snakebites that lack prompt access to serum therapy. Andrographis serpyllifolia (Vahl), belonging to Acanthaceae, has been recorded in ethnobotanical archives as a plant possessing potent anti-ophidic activity for snake bites. The present study emphasis to investigate the phytochemical pro...
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PREFORMULATION, FORMULATION DEVELOPMENT AND DRUG RELEASE STUDIES OF DIPYRIDAMOLE FLOATING MICROBALLOONS
For the drugs possessing stomach and upper intestine as the absorption window, it has become high practical importance to improve their gastric residence time. The in vitro performance of the drug delivery being highly variable is ascertaining as gastric emptying is one of the complex mechanisms. Intense researches are being carried out for the development of multiparticulate systems, which are of...
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HERBONANOCEUTICALS: A NEWER APPROACH FOR DELIVERING HERBAL DRUGS
“Nanotechnology” is a science which deals with the particles less than the size of 100 nm. Materials at the atomic and molecular scales are engineered and manufactured by this technology. The use of nanotechnology for “phytotherapy” or treatment of various diseases by herbal medicines/drugs, including herbal drug delivery, where current and emerging nanotechnologies could enable entirely n...
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IN-SILICO DOCKING OF BIOACTIVE COMPOUNDS DERIVED FROM CASSIA AURICULATA FLOWER EXTRACT AGAINST NS2B-NS3 PROTEASE OF DENGUE VIRUS
Dengue is a fatal disease connected to the environment that spreads rapidly. As there is currently no effective vaccine against dengue and no exact treatment for the disease, controlling and preventing dengue fever outbreaks are essential steps for keeping people healthy. Dengue viruses are a member of the Flaviviridae family, mosquito-borne, and causative agents for dengue fever. Bioactive compou...
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AN OVERVIEW OF AETIOPATHOGENESIS AND PREVENTION OF INFECTIOUS CANCERS
Currently, the knowledge on the oncogenic behaviour exhibited by microbial agents is the result of long and laborious studies conducted over the years. It started with the liver fluke infection associated with bile duct carcinoma and bilharziasis with bladder cancer. Following this, multiple pathogens got implicated in carcinogenesis, including bacteria, many viruses, and even fungi. For some of t...
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NANOCERIA / CERIUM OXIDE NANOPARTICLES: SYNTHESIS AND ITS ANTIOXIDANT PROPERTY IN TREATMENT OF VARIOUS DISEASES AND ITS NOVEL APPROACH TO TREAT OCULAR DISEASES
Cerium oxide nanoparticles, also known as Nanoceria, have attracted a lot of attention due to their remarkable catalytic activities, which result from a rapid and efficient modification of the oxidized state between Ce4+ and Ce3+. The cerium atom may quickly and dramatically change its electrical arrangement to better suit its immediate surroundings. It also has oxygen vacancies, or flaws, in the ...
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CUBOSOME: A NOVEL VESICULAR DRUG DELIVERY SYSTEM
Cubosomes are square and rounded particles with internal cubic lattice. Cubosomes are thermodynamically stable and consist of honeycombed (cavernous) structures separating two internal aqueous channels and a large interfacial area. Cubosomeisa novel biocompatible drug delivery system whose diameter size range from 10–500 nm. Cubosomes possessa great significance in the field of cosmeceuticals an...
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