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SUSTAINED RELEASE OPHTHALMIC IN-SITU GELS OF DORZOLAMIDE HCl FOR GLAUCOMA-AN APPROACH TO FORMULATION AND IN-VITRO EVALUATION
The objective of the present investigation was to formulate the thermosensitive ophthalmic in-situ gels of Dorzolamide HCl for the treatment of glaucoma. Dorzolamide HCl is presently available as conventional eye drops, which has demerits like pre-corneal elimination, lachrymal drainage and no sustained effect leading to poor bioavailability and hence there was a need to develop a better, stable a...
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FORMULATION AND EVALUATION OF DORZOLAMIDE SPANLASTICS
Dorzolamide is commonly used to treat glaucoma, damage in the eye often caused by abnormally high pressure in the eye. It is one of the carbonic anhydrase inhibitors which is effective in decreasing intraocular pressure by decreasing the production of the aqueous humor. The main objective of the study was to entrap dorzolamide in a novel nanovesicular carrier system (spanlastics) to ensure sustain...
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PHYTOCHEMICAL SCREENING AND EVALUATION OF ANTI-DIARRHEAL POTENTIALITY OF PLUMERIA ALBA LINN. LEAVES
Plumeria alba Linn. belonging to the family Apocynaceae (Dogbane family) is the flowering plant. P. alba is used as a purgative, rubefacient in rheumatism, asthma, piles, gonorrhea, blood disorders and tumors, mentioned in the traditional system of medicine. The present study was carried out to establish the pharmacognostic studies, physicochemical parameters along with a preliminary phytochemical...
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ANTIMICROBIAL ACTIVITY OF TERMINALIA BELLERICA (GAERTN.) ROXB. AGAINST MULTIDRUG-RESISTANT STAPHYLOCOCCUS SAPROPHYTICUS
The present study investigates the isolation and identification of Multi-Drug Resistant bacteria from Hospital Effluent and the determination of Antimicrobial activity of Terminalia bellerica (Roxb.) against the isolated Multi Drug-Resistant Bacteria. Hospital effluent was collected and screened for the presence of Drug resistance phenotype against five different antibiotics, and the isolated bact...
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NANO STRUCTURED LIPID CARRIER SYSTEM- A NOVEL TARGETING CARRIER
Oral administration of drugs is considered a convenient route; however, various drugs that are insoluble in water or cannot permeate across gastrointestinal tract membrane cannot be delivered by this route. To enhance the permeability through the physiological barriers, lipophilic drugs are introduced but, lipophilic drugs have low oral bioavailability. To enhance the bioavailability, a third-gene...
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A REVIEW ON THE ROLE OF NATURAL REMEDIES IN PSORIASIS THERAPY
Psoriasis is a chronic inflammatory disease that affects about 1-2% population. It is caused by different factors, the most common cause being genetic predisposition. Other causes or factors that can trigger psoriasis include infection, physical trauma to the skin, stress and certain medication, for example, beta-blockers and antimalarials. People suffering from psoriasis are at a greater risk of ...
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REVERSE PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR SEPARATION AND ESTIMATION OF IMPURITIES PRESENT IN PHARMACEUTICAL FORMULATION OF CANAGLIFOZIN
Canagliflozin is sodium-glucose co-transporter-2 inhibitors work by inhibiting SGLT2 to prevent reabsorption of glucose and facilitate its excretion in urine. Impurities in pharmaceuticals which are unwanted chemicals that remain with the active pharmaceutical ingredients (APIs), or develop during stability testing, or develop during formulation or upon aging of both API and formulation. The prese...
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ANTIBACTERIAL ACTIVITY AND DNA BINDING PROPERTIES OF BIVALENT METAL COMPLEXES WITH CUMINALDEHYDE BENZOYLHYDRAZONE (CABH)
Cobalt(II), nickel(II), copper(II) and zinc(II) complexes having the general formula ML2 (where, L= cuminaldehyde benzoyl-hydrazone, CABH) have been synthesized and characterized based on mass spectra, molar conductivity, FT-IR and UV-Vis spectral data. The complexes are found to be non-electrolytes. FT-IR data suggest that the CABH acts as a uni-negative bidentate ligand. The copper complex is in...
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ETHNOMEDICINAL VALUES AND ANTIDIABETIC POTENTIAL OF CLERODENDRUM SPP. OCCURRING IN NORTHEASTERN REGION
The present study was undertaken to systematically analyze, document the traditional knowledge of Clerodendrum species use for the treatment of various human ailments from NER. The information was collected by literature survey as well as by consulting questionnaire with the villagers and local communities of NER. A total of twelve Clerodendrum species were collected, and among them, C. colebrooki...
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FORMULATION AND EVALUATION OF SAGO STARCH FILM CONTAINING LEVOCETIRIZINE DIHYDROCHLORIDE
Levocetirizine dihydrochloride is an orally active, third-generation non-sedative antihistamine used in the symptomatic relief of seasonal and perennial allergic rhinitis. It competes with endogenous histamine for binding at peripheral H1-receptor sites on the effector cell surface. The present work aimed to prepare mucoadhesive buccal films to deliver the drug in a controlled manner with a longer...
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