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FORMULATION, CHARACTERIZATION AND EVALUATION OF SOLID LIPID NANOPARTICLES OF SELECTED ANTITUBERCULAR AGENT
The purpose of this work was to develop prolonged-release solid lipid nanoparticles (SLNs) of Rifampicin (RIF) for oral drug delivery and to improve the bioavailability of RIF. SLNs were designed by using Glycerol monostearate (GMS) and lipid core materials and polaxamer 188 as a stabilizer. SLNs were prepared by o/w microemulsion technique and characterized by particle size analysis, Fourier tran...
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ACUTE AND SUB ACUTE TOXICITY STUDY OF HYDROALCOHOLIC EXTRACT OF UNANI FORMULATION: (MAJOON HAJRUL YAHOOD) USED IN UROLITHIASIS
Background: Majoon hajrul yahood is a polyherbomineral formulation commonly used in the Unani system of medicine for the management of urolithiasis. In this study safety of a hydroalcoholic extract of majoon hajrul yahood was evaluate in Wistar rats. Materials and Methods: The hydroalcoholic extract of the formulation were tested for acute and sub-acute toxicity study. The single-dose (300, 2000, ...
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NANOCERIA / CERIUM OXIDE NANOPARTICLES: SYNTHESIS AND ITS ANTIOXIDANT PROPERTY IN TREATMENT OF VARIOUS DISEASES AND ITS NOVEL APPROACH TO TREAT OCULAR DISEASES
Cerium oxide nanoparticles, also known as Nanoceria, have attracted a lot of attention due to their remarkable catalytic activities, which result from a rapid and efficient modification of the oxidized state between Ce4+ and Ce3+. The cerium atom may quickly and dramatically change its electrical arrangement to better suit its immediate surroundings. It also has oxygen vacancies, or flaws, in the ...
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CUBOSOME: A NOVEL VESICULAR DRUG DELIVERY SYSTEM
Cubosomes are square and rounded particles with internal cubic lattice. Cubosomes are thermodynamically stable and consist of honeycombed (cavernous) structures separating two internal aqueous channels and a large interfacial area. Cubosomeisa novel biocompatible drug delivery system whose diameter size range from 10–500 nm. Cubosomes possessa great significance in the field of cosmeceuticals an...
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DEVELOPMENT OF FUROSEMIDE FLOATING MICROBALLOONS: IN-VITRO AND IN-VIVO EVALUATION
The present investigation deals with the development and evaluation of floating microballoons of furosemide to extend the gastric residence time (GRT) and prolong the drug release. In the present work, floating micro balloons of furosemide were formulated using eudragit RS 100, eudragit S 100, and HPMC K4M and ethylcellulose polymers by the solvent evaporation method. The prepared micro balloons w...
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STEADY SHEAR AND DYNAMIC SHEAR RHEOLOGICAL PROPERTIES OF CARBOXYMETHYL LOCUST BEAN GUM INFLUENCING EROSION OF THE POLYSACCHARIDE COAT OF COMPRESSION COATED TABLETS
Pulsatile drug delivery is one such system thereby delivering drug at the right time, right place and in right amounts and holds good promises and provides benefit to the patients suffering from chronic problems like arthritis, asthma, hypertension, etc. The present study investigated that optimization of quinapril hydrochloride was successfully done and batch A8 was given satisfactory results. Ta...
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PREFORMULATION, FORMULATION DEVELOPMENT AND DRUG RELEASE STUDIES OF DIPYRIDAMOLE FLOATING MICROBALLOONS
For the drugs possessing stomach and upper intestine as the absorption window, it has become high practical importance to improve their gastric residence time. The in vitro performance of the drug delivery being highly variable is ascertaining as gastric emptying is one of the complex mechanisms. Intense researches are being carried out for the development of multiparticulate systems, which are of...
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MOLECULAR DOCKING ANALYSIS OF PLANT PHYTOCOMPOUNDS AS PROMISING INHIBITORS AGAINST LASB VIRULENCE PROTEIN – AN IN-SILICO AND IN-VITRO APPROACH
Pseudomonas aeruginosa is a Gram-negative pathogenic bacterium that can cause a variety of hospital-acquired diseases. It is a multidrug-resistant bacterium and can survive a wide range of antibiotics; hence there is a concern about its limited therapy options. In this scenario, the discovery and development of novel antibiotics are in high demand. In our research work, molecular docking a Bioinfo...
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GREEN SYNTHESIS OF ZINC OXIDE NANOPARTICLES USING PRUNUS DOMESTICA (PLUM) FRUIT EXTRACT ITS CHARACTERIZATION, ANTIMICROBIAL AND ANTIOXIDANT STUDIES
Production of nanoparticles using plants is a new area of interest. Plum fruit extract was used for the biosynthesis of zinc oxide nanoparticles. Green synthesis of zinc oxide nanoparticles are considered as a eco-friendly methodusing materials from plants and other natural sources without using anyharmful chemicals. Plum fruit has many medicinal values such as antioxidant activity, cardiovascular...
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A BURDEN OF GASTROENTERITIS ASSOCIATED WITH COMORBIDITIES AN EFFECTIVE MANAGEMENT STRATEGY
Acute gastroenteritis prevalent amongst children and newborns is considered a serious infection globally. The Acute diarrhea as a result of gastroenteritis as per logistics suggest that there were more than 1.5 million outpatient visits along with 200,000 hospitalizations and 300 fatalities per year in children in U.S. Diarrhea is the leading cause of deaths amongst children with 30% relapse rate....
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