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EVALUATION OF PHYTOCHEMICAL COMPOSITION AND ANTI-OXIDANT POTENTIAL OF ANDROGRAPHIS SERPYLLIFOLIA (VAHL) WIGHT: AN ENDEMIC ANTI-OPHIDIC PLANT
In folk medicine, especially in developing countries, several plant species are employed for the treatment of snakebites that lack prompt access to serum therapy. Andrographis serpyllifolia (Vahl), belonging to Acanthaceae, has been recorded in ethnobotanical archives as a plant possessing potent anti-ophidic activity for snake bites. The present study emphasis to investigate the phytochemical pro...
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PHYTOCHEMICAL AND BIOLOGICAL SCREENING OF THREE SELECTED ETHNOMEDICINAL PLANTS FROM MIZORAM, INDIA
This research explores Achyranthes bidentata L., Adhatoda zeylanica and Aeginetia indica L's pharmacological potential. Antibacterial disc assay (20 mg/ml), antifungal disc assay (20 mg/ml) and antioxidant DPPH/reducing energy assay (50 μg/ml, 100 μg/ml and 200 μg/ml) were tested for biological operations of plant extracts (aqueous, methanol and acetone leaf extracts). Significant alkaloid cont...
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STRUCTURE ELUCIDATION OF OXIDATIVE DEGRADATION PRODUCT OF DROSPIRENONE
Stressed degradation study of Drospirenone in H2O2 and characterization of degradants by IR, NMR, LC-MS was done. Stressed degradation study of Drospirenone in H2O2 and characterization of degradants by IR, NMR, and LC-MS was done. To evaluate the stability of Drospirenone under stress conditions, it was subjected to oxidative degradation, according to ICH guideline Q1A (R2). The analysis was carr...
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IN-SILICO DOCKING OF BIOACTIVE COMPOUNDS DERIVED FROM CASSIA AURICULATA FLOWER EXTRACT AGAINST NS2B-NS3 PROTEASE OF DENGUE VIRUS
Dengue is a fatal disease connected to the environment that spreads rapidly. As there is currently no effective vaccine against dengue and no exact treatment for the disease, controlling and preventing dengue fever outbreaks are essential steps for keeping people healthy. Dengue viruses are a member of the Flaviviridae family, mosquito-borne, and causative agents for dengue fever. Bioactive compou...
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NANOCERIA / CERIUM OXIDE NANOPARTICLES: SYNTHESIS AND ITS ANTIOXIDANT PROPERTY IN TREATMENT OF VARIOUS DISEASES AND ITS NOVEL APPROACH TO TREAT OCULAR DISEASES
Cerium oxide nanoparticles, also known as Nanoceria, have attracted a lot of attention due to their remarkable catalytic activities, which result from a rapid and efficient modification of the oxidized state between Ce4+ and Ce3+. The cerium atom may quickly and dramatically change its electrical arrangement to better suit its immediate surroundings. It also has oxygen vacancies, or flaws, in the ...
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MOLECULAR DOCKING AND TOXICITY STUDIES OF SERIES OF COMPOUNDS FROM DIARYL UREA HITS & SPIRO PIPERIDINE INDOLINYL SERIES AS POTENTIAL P2Y1 RECEPTOR ANTAGONISTS
Scientific investigations revealed that the study of P2Y1 receptors is very much essential in the current scenario because of their potential role in related to various disorders/diseases like thrombosis, cardiovascular problems. P2Y1 receptors belong to G protein-coupled receptors, an important target for ADP induced platelet aggregation. Blockade of P2Y1 receptors leads to the treatment of throm...
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DEVELOPMENT, CHARACTERIZATION AND IN-VITRO ANTIFUNGAL EVALUATION OF PLANTEROSOMAL GEL OF GANODERMA LUCIDUM
Planterosomal gel exhibit better pharmacokinetic and pharmacodynamic profile than the conventional herbal extracts. The objective of the present research work was to develop, characterize and evaluate the in-vitro antifungal activity of planterosomal gel in comparison to pure plant extract. Planterosomal gel of Ganoderma lucidum was prepared by incorporating gelling agent in planterosomal suspensi...
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NASYA IN AYURVEDA: AN IN-DEPTH ANALYSIS OF ITS MECHANISMS
Nasya, one of the core detoxification therapies in Ayurveda, involves the administration of medicinal substances through the nasal passage. It is particularly effective for disorders affecting the head and neck region (above the clavicle), but it also influences the nervous and endocrine systems systemically. In Ayurveda, the nasal cavity (Nasa) is seen as a direct pathway to the brain (Shiras), a...
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HERBONANOCEUTICALS: A NEWER APPROACH FOR DELIVERING HERBAL DRUGS
“Nanotechnology” is a science which deals with the particles less than the size of 100 nm. Materials at the atomic and molecular scales are engineered and manufactured by this technology. The use of nanotechnology for “phytotherapy” or treatment of various diseases by herbal medicines/drugs, including herbal drug delivery, where current and emerging nanotechnologies could enable entirely n...
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SOCIO DEMOGRAPHIC CHARACTERISTICS OF LUNG CANCER PATIENTS IN NORTH MALABAR REGION OF KERALA, SOUTH INDIA
Background: Lung cancer is the most common malignant neoplasm worldwide, accounting for greater mortality than due to any other cancer. It accounts for about 13% of all new cancer cases and 19% of cancer-related deaths worldwide. In India, lung cancer comprises 6.9% of all new cases of cancer and 9.3% of all cancer-related mortality in both sexes. This study aimed to find out the socio-demographic...
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