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STUDY ON A NOVEL ACTINOMYCETE, STREPTOMYCES GANCIDICUS (MF464014) AND ENHANCING ITS TANNASE PRODUCING ABILITY BY OPTIMIZING GROWTH CONDITIONS IN SUBMERGED FERMENTATION
Tannase (Tannin acylhydrolase E. C. 3.1.1.20) is a ubiquitous enzyme catalyzes the hydrolysis of ester and depside bonds of hydrolyzable tannins, releasing glucose and gallic acid. Gallic acid is used in the food industry as a substrate for the chemical synthesis of food preservatives such as gallates and pyrogallol, propyl gallate being a very important food antioxidant and in the pharmaceutical ...
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PREVALENCE OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) IN CLINICAL SPECIMENS AND AMONG HOSPITAL STAFF NASAL CARRIERS IN KHARTOUM STATE
Staphylococcus aureus is a bacteria that causes a heavy epidemic disease burden worldwide. This study aimed to investigate the prevalence of Methicillin-Resistant Staphylococcus aureus (MRSA) and the presence of mecA gene as a virulence factor of S. aureus isolates from clinical isolates and hospital staff nasal carriers using a conventional PCR. A cross-sectional study involving eighty-one S. aur...
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MEDICINAL EFFECTS OF NIGELLA SATIVA IN GYNECOLOGICAL DISORDERS: A SYSTEMATIC REVIEW
Comprehensive search of previously published research was conducted in PubMed, Science Direct, Scopus, and google scholar databases for studies published between 2012 and August 2021. The keywords used in combination to search for articles included Nigella sativa and “Gynecology”. In the first stage, the total articles obtained from searching the above databases using the above keywords were p...
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ANTIOXIDANT POTENTIAL OF DIFFERENT PARTS (LEAVES, STEM, FRUIT, SEED, FLOWER AND ROOT) EXTRACTS OF CUCUMIS MELO VAR AGRESTIS
Cucumis melo var agrestis (CMA) is belongs to the family of Cucurbitaceae. This plant is also known as wild musk melon it is widely distributed in the coastal areas. Many of the Cucumis species were reported as antioxidants, but there is no report on the antioxidant activity of CMA. The present study is aimed to evaluate the phytochemical analysis and antioxidant activity of different parts (leave...
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ANTI-CANCER POTENTIAL OF MORUSINDICA HYBRID VARIETIES IN HT-29 CANCER CELL LINES: AN EXPLORATORY STUDY
Complementary alternative medicine focuses on discovering the potential of plants in prevention and management of chronic diseases. Although Morus species has been screened for various biological activities, studies reporting the pharmacological effects of Morus indica (MI) hybrid varieties viz., V1 and S36 is scarce. This study focused on screening the phytochemical composition of Morus indica V1...
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A NEW SERIES OF CHALCONES INCORPORATED WITH PYRIDINE MOIETY AS POTENTIAL ANTI-BACTERIAL AGENTS
A new series of chalcones have been designed and synthesized, which are incorporated with pyridine moiety chalcones possess heterocyclic rings like pyridine, pyrazole, indole, etc. These heterocycles are cyclic compounds in which one or more atoms of the ring are hetero atoms: O, N, S, P, etc. These are important components in many of the pharmaceuticals and therapeutic drugs. These are present in...
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COMPARATIVE MODELLING AND DOCKING STUDIES OF CYTOCHROME C OXIDASE SUBUNIT 1 PROTEIN
Cytochrome c oxidase, a mitochondrial metalloenzyme acting as the terminal enzyme of the mitochondrial respiratory chain. It provides a critical function in cellular respiration in both eukaryotes and prokaryotes. The recent development in technology has enabled researchers to understand the genetic, molecular, structural, and functional properties of proteins to identify appropriate targets again...
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PREPARATION AND EVALUATION OF NON-IONIC SURFACTANT VESICLE USING STATISTICAL OPTIMIZATION: OLMESARTAN USED AS MODEL DRUG
The purpose of the present work was to prepare and evaluate olmesartan-loaded non-ionic surfactant vesicles (niosomes) to get sustained release by increasing the solubility and bioavailability. Ether injection and thin-film hydration methods were used for the preparation of all formulations as per the factorial design to study the effect of the three independent variables X1 (amounts of span 60), ...
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OPTIMIZATION OF AN ANTI-CANCER METABOLITE PRODUCTION BY PENICILLIUM RUBENS JGIPR9 VIA RESPONSE SURFACE METHODOLOGY
There are many pharmaceutically important compounds from Penicillium sp. that made the fungal genera one of the most important sources for the production of bioactive metabolites. As per the results of our previous study, a bioactive metabolite, P5, from Penicillium rubens JGIPR9 had highly promising cytotoxic and anti-cancer potentials. This prompted us to undertake the current study, so as to op...
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PRELIMINARY PHYTOCHEMICAL SCREENING AND GC-MS ANALYSIS OF METHANOLIC LEAF EXTRACT OF TEPHROSIA FALCIFORMIS RAMASWAMI FROM INDIAN THAR DESERT
Present study was conducted to identify and characterize the phytoconstituents of methanolic extract of leaves of Tephrosia falciformis (Pers.) Ramaswami of family Fabaceae. The methanolic extract of leaves was subjected to qualitative screening for primary and secondary metabolites as per standard methods; further GC-MS analysis was carried out for the identification of secondary metabolites. The...
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