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EVALUATION OF PHYTOCHEMICAL COMPOSITION AND ANTI-OXIDANT POTENTIAL OF ANDROGRAPHIS SERPYLLIFOLIA (VAHL) WIGHT: AN ENDEMIC ANTI-OPHIDIC PLANT
In folk medicine, especially in developing countries, several plant species are employed for the treatment of snakebites that lack prompt access to serum therapy. Andrographis serpyllifolia (Vahl), belonging to Acanthaceae, has been recorded in ethnobotanical archives as a plant possessing potent anti-ophidic activity for snake bites. The present study emphasis to investigate the phytochemical pro...
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STRUCTURE ELUCIDATION OF OXIDATIVE DEGRADATION PRODUCT OF DROSPIRENONE
Stressed degradation study of Drospirenone in H2O2 and characterization of degradants by IR, NMR, LC-MS was done. Stressed degradation study of Drospirenone in H2O2 and characterization of degradants by IR, NMR, and LC-MS was done. To evaluate the stability of Drospirenone under stress conditions, it was subjected to oxidative degradation, according to ICH guideline Q1A (R2). The analysis was carr...
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HERBONANOCEUTICALS: A NEWER APPROACH FOR DELIVERING HERBAL DRUGS
“Nanotechnology” is a science which deals with the particles less than the size of 100 nm. Materials at the atomic and molecular scales are engineered and manufactured by this technology. The use of nanotechnology for “phytotherapy” or treatment of various diseases by herbal medicines/drugs, including herbal drug delivery, where current and emerging nanotechnologies could enable entirely n...
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IN-SILICO DOCKING OF BIOACTIVE COMPOUNDS DERIVED FROM CASSIA AURICULATA FLOWER EXTRACT AGAINST NS2B-NS3 PROTEASE OF DENGUE VIRUS
Dengue is a fatal disease connected to the environment that spreads rapidly. As there is currently no effective vaccine against dengue and no exact treatment for the disease, controlling and preventing dengue fever outbreaks are essential steps for keeping people healthy. Dengue viruses are a member of the Flaviviridae family, mosquito-borne, and causative agents for dengue fever. Bioactive compou...
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EVALUATION OF CORRELATION BETWEEN GLYCATED HEMOGLOBIN AND HEMATOLOGICAL INDICES IN TYPE 2 DIABETES MELLITUS PATIENTS
Diabetes Mellitus increases the risk of both microvascular and macrovascular complications, out of which CVD affects approximately 32.2% of people with Type 2 Diabetes Mellitus globally. It is predicted that for every 1% increase in HbA1c is associated with a 30% increase in all-cause mortality and a 40% increase in CVD mortality in T2DM patients. This study aims to evaluate the correlation of Hb...
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FORMULATION AND EVALUATION OF SUSTAINED-RELEASE TABLET OF TRAZODONE HYDROCHLORIDE
The main objective of this study was to formulate a Sustained release tablet by wet granulation method. A sustained release tablet of trazadone hydrochloride was prepared by using synthetic polymer. The prepared tablets were evaluated for their diameter, thickness, drug content, Hardness, friability, weight variation. The thickness and diameter of the tablet range from 5.43±0.288 to 5.76±0.05 an...
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SYNTHESIS, CHARACTERIZATION AND BINDING PROPERTIES TOWARDS CT-DNA OF MIXED-LIGAND Cu(II) COMPLEX WITH 2-AMINOBENZONITRLE AND OCTANOATE ION
A novel coordination complex of 2-aminobenzonitrile (ABN) and octanoate ion (OC) with Cu(II) metal ion has been prepared by using microwave irradiation. The molecular formula and the geometry of the complex have been deduced from elemental analysis, molar conductance, magnetic moment, electronic spectra, FT- IR spectra, cyclic voltammetry, thermal analysis and EPR spectra. The molar conductance va...
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DEVELOPMENT OF RP-HPLC METHOD FOR SIMULTANEOUS EVALUATION OF UNIFORMITY OF DOSAGE UNITS FROM ASPIRIN AND DIPYRIDAMOLE EXTENDED-RELEASE CAPSULES
The aim of the present study is to develop a stability-indicating reverse-phase high-performance liquid chromatography method for the simultaneous estimation of Aspirin and Dipyridamole in combined extended-release dosage form 25/200mg, using a single unit of the capsule. Materials and Methods: Chromatographic separation was achieved with Agilent's high-performance liquid chromatography and X brid...
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ANTI-DIABETIC AND ANTI-OBESITY EFFECT OF FUNCTIONALLY ACTIVE PROTEINS OBTAINED FROM SEVEN EDIBLE INSECTS
The bioactive peptides derived from food have increased consideration for their function in averting numerous chronic diseases, comprising, diabetes and obesity. Edible insects are the feasible composition of bioactive peptides owing to their high protein content and viable production. The present study was aimed to evaluate the antidiabetic and anti-obesity effects of seven edible insects’ prot...
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ISOLATION AND TAXONOMIC CHARACTERISATION OF POTENTIAL ANTAGONISTIC SIMPLICILLIUM LANOSONIVEUM VJCH-19 FROM MANGROVES OF ADAVULADEEVI, ANDHRA PRADESH, INDIA
Objectives: The intention of the present study was to isolate and identify cultural conditions of potent fungal strain VJCH-19 with antagonistic activities isolated from mangrove ecosystems of Adavuladeevi, South coast, Andhra Pradesh, India. Methods: The soil samples were collected from the mangrove habitats and shade dried. The serial dilution plate technique was employed for the isolation of ma...
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