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FORSKOLIN INDUCED MORPHOLOGICAL AND OVARIAN DEFORMITIES IN THE EXORISTA BOMBYCIS (UZI FLY) AND ANTI-FEEDENT ACTIVITY OF FORSKOLIN
Forskolin is a heterocyclic labdane-type diterpenoid extracted from the roots of the plant of Coleus forskohlii (Lamiaceae) has been studied in depth for its broad range of pharmacological properties. Coleus forskohlii aids in the control of pestilence of Uzi fly, Exorista sorbillans, and Exorista bombycis one of the gravest ecumenical pests in sericulture industry. Forskolin affected moulting; de...
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ISOLATION OF BIOSURFACTANT-PRODUCING BACTERIA FROM OIL-SPILLED SOIL AND CHARACTERIZATION OF THEIR SECRETED BIOSURFACTANTS IN PATHOGEN-INHIBITION AND OIL-EMULSIFICATION
Microbial biosurfactants are surface-active amphiphilic molecules produced by bacteria, yeast and fungi. Biosurfactant-producing bacteria, often recovered from oil-polluted sites, have significant role in microbial enhanced oil recovery (MEOR), environmental sustainability and pharmaceutical applications. The objective of the present study includes isolation, screening and selection of biosurfacta...
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DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR ESTIMATION OF VORAPAXAR BY UPLC-MS/MS: APPLICATION TO A PHARMACOKINETIC STUDY
The validated analytical method was applied for estimation of vorapaxar in aqueous and human plasma with vorapaxar-D5 as an internal standard by using UPLC-ESI-MS/MS. The chromatographic separation was achieved with 5mM Ammonium Formate Buffer (pH: 4.0): Methanol: Acetontrile, (40:30:30, % v/v) using the Pursuit XRs-100Å, C18, 4.6 × 50 mm, 10 µm. The total analysis time was 3.5 min and flow rat...
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PROBIOTICS: ANAVANT-GARDESTEP INTHE THERAPY OF RHEUMATOID ARTHRITIS
Rheumatoid arthritis (RA) is a chronic progressive inflammatory autoimmune ailment with multifactorial etiology. The human gut is a massive intricate ecosystem where microbiota, nutrients, and host cells interact extensively to uphold gut homeostasis. Gut microbiota acts as a modulator of immunity and dysbiosis has detrimental effects on health by triggering a persistent inflammatory response that...
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SCREENING OF TERATOGENICITY OF THE MARINE ALGA SYMPHYOCLADIA LATIUSCULA
Objective: To explore the Teratogenicity of isolated Polyphenols of Symphyocladia latiuscula (PSL) on pregnant female rats. Experimental Design: The marine alga Symphyocladia latiuscula were the preparation of methanolic extract followed by isolation of Polyphenols. The Teratogenic study was performed according to the OECD guidelines, no 415. And the test drug; PSL 100, 200 and 1000 mg/kg and posi...
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DESIGN AND CHARACTERIZATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF HERBAL DRUG COMPOUND
A glycyrrhetinic acid isolated from herbal plant Glycyrrhiza glabra (family Fabaceae), commonly known as licorice is used to formulate microemulsion as a self-emulsifying drug delivery system for oral administration using almond oil as the oil phase. Pseudoternary phase diagrams were constructed to determine the microemulsion existence region using surfactant (Tween 80) and co-surfactant (propylen...
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A STATISTICAL APPROACH TO THE DEVELOPMENT OF FAST DISINTEGRATING TABLETS OF TELMISARTAN USING CO-PROCESSED SUPERDISINTEGRANT
The present investigation deals with fast disintegrating tablets of the model drug (Telmisartan) and to determine the influence of the excipients on physical properties of tablets. Employing a Box Behnken design, concentration of co-processed superdisintegrants (Crosspovidone: sodium starch glycolate) (X1), the concentration of meglumine (X2) and concentration of sodium lauryl sulfate (X3), select...
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A VALIDATED STABILITY INDICATING RP-HPLC METHOD OF ESTIMATION OF PIOGLITAZONE HCL IN DOSAGE FORM
This present study aims to develop an accurate, precise, and linear reverse-phase High-Performance Liquid Chromatographic (RP-HPLC) method for the estimation of Pioglitazone HCL in Pharmaceutical dosage form. Method: The chromatographic system employs a reverse-phase Hypersil BDS, C8 250 × 4.6 mm, 5 columns using 0.01M Potassium phosphate buffer and acetonitrile (40:60) as mobile phase, methanol ...
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STABILITY INDICATING GREEN ANALYTICAL GAS CHROMATOGRAPHY METHOD FOR THE DETERMINATION OF DIPHENHYDRAMINE IN PURE AND MARKETED FORMULATIONS
The current work defines development of a simple, rapid and precise method based on gas chromatography coupled with Flame Ionization Detector (GC-FID) for the quantitative estimation of diphenhydramine (DPH) present in the marketed formulations following the principles of green analytical chemistry. The analysis was performed using Zebron Phase: ZB-DRUG-1 column with Nitrogen as a carrier gas havi...
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COMPARATIVE ANALYSIS OF PHYTOCHEMICAL CONSTITUENTS, FREE RADICAL SCAVENGING ACTIVITY AND GC-MS ANALYSIS OF LEAF AND FLOWER EXTRACT OF TITHONIA DIVERSIFOLIA (HEMSL.) A. GRAY
The secondary plant metabolites possess therapeutic value, thus play a significant role in human health and general wellbeing. The present study aimed to estimate the secondary metabolite concentration and to evaluate the antioxidant potential of Tithonia diversifolia leaf and flower extract in methanol. The phytochemical compounds in the extracts were characterized through Gas Chromatography-Mass...
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