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MAGNETIC NANOPARTICLES FOR THEIR THERAPEUTIC APPLICATIONS
Magnetic nanoparticles are hugely used in hyperthermia, targeted drug delivery processes, diagnosis, extraction, and cellular imaging of biological molecules, which can be widely used in cancer treatment. The focus of attention is on formation, features, types, made work, coating material, and therapeutic application of magnetic nanoparticles. It also pivots in safety and biocompatibility in magne...
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ANTIBIOTICS SUSCEPTIBILITY IN CHRONIC SUPPURATIVE OTITIS MEDIA (CSOM) AT THE SECONDARY CARE HOSPITAL IN NORTH INDIA
Background: Chronic suppurative otitis media (CSOM) is defined as a persistent infection of the middle ear cleft with a perforated tympanic membrane and draining exudate for more than 6weeks. Information about the organism responsible for COSM and their antibiotic susceptibility is important for effective treatment. Material and Methods: A prospective cross-sectional study was conducted on 85 pati...
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STUDIES ON GC-MS PROFILING OF SOME SEAWEEDS OF MAHIM BEACH DIST. PALGHAR, MAHARASHTRA USING VARIOUS SOLVENTS
Objective: To investigate the bioactive constituents of Ulva lactuca, Sargassum prismaticum, and Sarconema filiforme using gas chromatography-mass spectrometry (GC-MS) analysis. Methods: 10 gm sample of each seaweed was successfully extracted with HPLC grade methanol and pet. ether with continuous shaking in a dark room for 36 h. The concentrated extracts were subjected to GC MS analysis. Results:...
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IN DEPTH STUDY ABOUT CHROMOSOMAL NON-DISJUNCTION IN A BRIEF REVIEW
Chromosomal non-disjunction is a pivotal error in cell division where chromosomes fall to separate properly during meiosis or mitosis, resulting in an abnormal number of chromosomes, the condition is known as aneuploidy. This phenomenon has significant consequences for human health, as it underpins several kinds of genetic disease, such as Downsyndrome, Turner syndrome and Klinefelter syndrome. No...
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ANTIMICROBIAL PROTEINS/PEPTIDES ISOLATED FROM TWO CULTIVARS OF BOUGAINVILLEA
The rapid increase in multi-drug resistance (MDR) infections present a challenge in the development of therapies against them. Antimicrobial peptides (AMPs) can be the answer to this challenge. AMPs play an important role in host defense mechanisms. Plants are the precious source of natural antimicrobial molecules, including antimicrobial peptides known as Plant Antimicrobial Peptides (PAMPs). The...
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Co(II), Ni(II), Cu(II) COMPLEXES OF SULPHUR CONTAINING SCHIFF BASE LIGAND-SYNTHESIS, SPECTROSCOPIC, MOLECULAR MODELLING AND ANTIMICROBIAL STUDIES
Metal (II) complexes of Co, Ni and Cu with Schiff base derived from 2, 4-Dihydroxy-5-acetylacetophenone and Aminothiophenol (DAAAP) were synthesized and characterized by elemental analysis, FTIR, IH NMR, electronic spectra, thermal analysis, magnetic susceptibility and conductometric measurements. On the basis of these studies, a six coordinated octahedral geometry has been proposed for all the co...
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DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC METHOD FOR ESTIMATION OF DARUNAVIR
A simple, precise, and sensitive stability-indicating high-performance thin layer chromatographic (HPTLC) method has been developed and validated for the analysis of Darunavir in bulk and in the tablet dosage form. The separation was performed on pre-coated silica gel 60 GF254 plates using Toluene: Methanol: Triethylamine (8.5:1:0.5 v/v/v) as the mobile phase. The retention factor (Rf) was found t...
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FORMULATION AND PHYSICAL EVALUATION OF GLUCOCORTICOID LOADED TEA TREE OIL NANOEMULSION: A SUMMARIZED TECHNICAL NOTE
Clobetasol propionate (CP) has anti-inflammatory, immunomodulatory, and anti-proliferative activity. The current work aimed to prepare and evaluate the nanoemulsions of CP loaded tea tree oil (TTO) would be stable nanoemulsion. Clinical use of CP is restricted to some extent due to its poor permeability across the skin. So, to increase its permeation across the skin, microemulsion based formulatio...
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STABILITY INDICATING LC-ASSAY METHOD FOR METFORMIN HYDROCHLORIDE AND TENELIGLIPTIN HYDROBROMIDE FROM TABLET FORMULATIONS
A simple, rapid, accurate, robust, and specific HPLC method was developed for the assay of metformin hydrochloride and teneligliptin hydrobromide from the oral tablet formulations. Stability-indicating reverse-phase chromatographic method was developed on a RP C18 column (250 mm × 4.6 mm, 5µm) using a mixture of 20 mM ammonium acetate of pH 5.5 and methanol in the ratio 50:50 v/v as mobile phase...
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METHODS OF EXTRACTION AND FRACTIONATION OF BIO-ACTIVE COMPONENTS OF MORINDA COREIA FOR ANTI-TUBERCULAR AND ANTICANCER ACTIVITIES
In Asian countries, roots, barks, stems, leaves, and fruits of plants belonging to the Morinda species are considered as valuable traditional herbs. They are used in folk medicine for the treatment of many diseases, including diabetes, high blood pressure, and cancer. Anti-tubercular and cytotoxic activities of Morinda citrifolia (noni) have been reported, but Morinda coreia has not been explored ...
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