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ISOLATION AND STRUCTURAL ELUCIDATION OF IMPURITY IN NEBIVOLOL
In the synthesis of Nebivolol [a mixture of (1RS, 1' RS)-1,1'-{(2RS, 2' SR)-bis(6-fluoro 3, 4-dihydro-2H-1-benzopyran-2-yl)} -2,2'-iminodiethanol] having four chiral centers, one crucial isomeric impurity at 0.88 RRT was observed in HPLC related substance analysis in gradient HPLC method. This impurity was isolated from synthesized crude impurity substance by preparative HPLC with chiral normal ph...
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METHODS OF EXTRACTION AND FRACTIONATION OF BIO-ACTIVE COMPONENTS OF MORINDA COREIA FOR ANTI-TUBERCULAR AND ANTICANCER ACTIVITIES
In Asian countries, roots, barks, stems, leaves, and fruits of plants belonging to the Morinda species are considered as valuable traditional herbs. They are used in folk medicine for the treatment of many diseases, including diabetes, high blood pressure, and cancer. Anti-tubercular and cytotoxic activities of Morinda citrifolia (noni) have been reported, but Morinda coreia has not been explored ...
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PREDICTION OF HOTSPOT IN PROTEIN-PROTEIN/PROTEIN-SUBSTRATE INTERACTION: A NOVEL COMPUTATIONAL APPROACH
Protein-protein, as well as protein-substrate interactions, play an important role in regulating specific biological functions like signal transduction, apoptosis, gene regulation, and immune response. These play a major role in drug discovery applications and can be used as molecular targets to stop disease development at the molecular level. Thus, understanding the biological mechanism of protei...
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UNLOCKING THE ADAPTOGENIC POWER OF ROSEMARY (ROSMARINUS OFFICINALIS): A COMPREHENSIVE EXPLORATION OF ITS PHARMACOLOGICAL POTENTIAL FOR STRESS RESILIENCE AND HOLISTIC WELL-BEING
Rosmarinic acid, a key component of Rosemary (Rosmarinus officinalis), holds significant promise as an adaptogen in herbal medicine, offering a natural remedy to counteract stress's wide-ranging impacts on health. This abstract explores rosmarinic acid's pharmacological activities, emphasizing its modulation of the hypothalamic-pituitary-adrenal (HPA) axis, regulation of neurotransmitters, antioxi...
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PHARMACEUTICAL PROCESSING AND ANALYTICAL CHARACTERIZATION OF METAL-BASED AYURVEDIC DRUG “TAMRA BHASMA”
The preparation of metal-based Indian traditional drugs involves the conversion of pure metal into its therapeutically effective form. “Tamra Bhasma” (calcined copper) is one such herbometallic preparation used for various medical conditions like anaemia, obesity, and skin disease, disorders of the liver and spleen, hyper-acidity, rhinitis, hemorrhoids. A detailed evaluation of the changes occ...
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EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF TILIACORA ACUMINATA EXTRACT IN RATS
Inflammation is part of the body's immune response. There can be four primary indicators of inflammation: pain, redness, heat or warmness and swelling. Plants have the ability to synthesize a wide verity of phytochemical compounds as secondary metabolites which shows anti-inflammatory activity. The anti-inflammatory activity of ethanol extract of Tiliacora acuminata stem and leaf was evaluated usi...
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FORMULATION AND EVALUATION OF BIOADHESIVE BUCCAL TABLETS OF ENALAPRIL MALEATE
Enalapril maleate competitively inhibits the ACE to hinder the production of angiotensin II, a key component of the rennin angiotensin aldosterone system that promotes vasoconstriction and reabsorption of sodium ion in the kidney, overall decrease in blood pressure. The study's main objective was to formulate and evaluate bioadhesive buccal tablets to avoid the first-pass metabolism in the liver a...
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FORMULATION AND EVALUATION OF MUCOADHESIVE MATRIX TABLET OF ACYCLOVIR
The binding capacity of mucoadhesive polymers with gastric mucin prolongs the gastric residence time, increasing bioavailability. In the present research work, an attempt was made to formulate and evaluate sustain release mucoadhesive matrix tablet of Acyclovir. In the present work, an effort has been made to evaluate the effect of mucoadhesive polymers on the release characteristics of mucoadhesi...
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ANTIMICROBIAL PROTEINS/PEPTIDES ISOLATED FROM TWO CULTIVARS OF BOUGAINVILLEA
The rapid increase in multi-drug resistance (MDR) infections present a challenge in the development of therapies against them. Antimicrobial peptides (AMPs) can be the answer to this challenge. AMPs play an important role in host defense mechanisms. Plants are the precious source of natural antimicrobial molecules, including antimicrobial peptides known as Plant Antimicrobial Peptides (PAMPs). The...
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A REVIEW ON PREPARATION & METHODS OF CURCUMIN NANOPARTICLES AND ITS APPLICATION
Curcumin is a highly potent, nontoxic, bioactive agent found in turmeric and has been known for centuries as a household remedy to many ailments. The main active ingredient of turmeric is curcumin, a polyphenol that helps prevent and control neurological, respiratory, cardiovascular, metabolic, inflammatory and autoimmune diseases and some cancers. The major drawbacks of curcumin are low absorptio...
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