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EVALUATION OF ANTIDIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF METHANOLIC ROOT EXTRACTS OF WITHANIA SOMNIFERA, BOERHAAVIA DIFFUSA AND THEIR COMBINATION IN DEXAMETHASONE INDUCED DIABETIC RATS
Diabetes mellitus is one of the major public health problems throughout the world. Current therapies, especially synthetic drugs, often fail to bring back normal glycemic control without complications. Numerous herbal medicines are widely explored as alternative medicine in diabetes. The objective of this work was to evaluate the antidiabetic activity of such herbal extracts of roots of Withania s...
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DEVELOPMENT AND CHARACTERIZATION OF ORODISPERSIBLE TABLETS CONTAINING PARACETAMOL GRANULES COATED WITH TASTE-MASKING TECHNOLOGY
Orodispersible tablet technology allows tablets to be administered without the need for additional water, which would increase pediatric patient compliance. In this paper, an orodispersible paracetamol tablet formulation with flavor masking technology was developed. For this purpose, the methacrylic acid-derived polymer, Eudragit® E100, has the ability to form films on particles, which are insolu...
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MICROSPONGES: A PROMISING APPROACH FOR DRUG DELIVERY
Micro sponges are patented polymeric drug delivery systems consisting of porous microspheres. The physical appearance of microsponges is tiny spherical sponge-like with the surface with large spores. Micro sponges are typically used and nowadays used as the oral dosage form. The inert and indestructible tiny spherical particles do not pass through the skin. But, it collects in the tiny nooks and c...
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PHARMACOKINETIC DRUG INTERACTIONS BETWEEN HMG-COA REDUCTASE INHIBITORS PITAVASTATIN WITH CONCOMITANTLY USED TICAGRELOR
In the present research, the pharmacokinetic Drug-drug interactions between HMG-COA reductase inhibitors Pitavastatin with concomitantly used Ticagrelor have been studied. Pitavastatin is a member of the blood cholesterol lowering medication class of statins while Ticagrelor is a platelet aggregation inhibitor. Combination therapy with statins and other cardiovascular medications is recommended fo...
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BIORELEVANT DISSOLUTION METHOD DEVELOPMENT OF MEMANTINE EXTENDED-RELEASE CAPSULES FOR PREDICTION OF PRE-PRANDIAL IN-VIVO PERFORMANCE
The main objective of this research work is to develop biorelevant dissolution method for the Memantine extended-release capsule by correlating pre-prandial in-vivo performance. The mean plasma concentration profile obtained after oral administration of extended-release capsules was deconvoluted using the Wagner-Nelson deconvolution technique for deriving the percentage fraction of drug absorbed t...
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A REVIEW ON TRADITIONAL MEDICINAL PLANTS USED AS ANTIDOTES IN THE TREATMENT OF SNAKE BITES IN INDIA
Envenoming and deaths resulting from snakebites are particularly important public health problems in the rural tropics. Snake envenomation is included since 2009 in the World Health Organization (WHO) list of Neglected Tropical Diseases, as this condition remains largely neglected by national and international health authorities. The only available specific treatment is antivenom therapy, which co...
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ANIMAL MODELS USED IN THE SCREENING OF ANTIEPILEPTIC DRUGS
Epilepsy is a disorder of episodic brain dysfunction characterized by recurrent unprovoked spontaneous seizures. Epilepsy is the second most common neurological disorder after stroke. Antiepileptic drug discovery in animal models starts with the assumption that the experimental seizure model mimics human seizure. The identification of potential therapeutic agents for the treatment of epilepsy requ...
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ANTICANCER ACTIVITY OF EPIPHYLLUM OXYPETALUM (DC.) LEAVES EXTRACT BY IN-VIVO IN-VITRO MODELS
Colon carcinogenesis is a multistep process that arises by the accretion of genetic alterations. The genetic and epigenetic changes which transform normal colonic epithelium into aberrant crypt foci which is responsible for penetration. The GC-MS analysis of ethanolic extract of Epiphyllum oxypetalum (DC.) have shown the presence of phenolic compound (4-hydroxy-2-methylacetophenone), Diterpen...
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FABRICATION OF CHITOSAN ALGINATE NANOPARTICLE BASED FIBRE OPTIC BIOSENSOR
In this work, a highly sensitive and selective nanoparticle-based fluorometric biosensor has been reported for the detection of asparagine levels. The L-asparaginase loaded chitosan alginate nanoparticles of size 396 nm with 600 µL of L-asparaginase (44.4 IU/mg) showing 83.5% entrapment efficiency was fabricated via ionic gelation method. In the presence of enzyme L-asparaginase (biocomponent) th...
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EVALUATION OF COGNITION ENHANCING ACTIVITY OF SESBANIA GRANDIFLORA (L.) FRUITS EXTRACT ON HIGH FAT DIET INDUCED DEMENTIA
The study was aimed to justify the traditional claim of fruits of Sesbania grandiflora (Leguminosae) as a medhya rasayana. Dementia was induced with chronic administration of a high fat diet for 90 days. Petroleum ether, benzene, chloroform, acetone, ethanol extracts of fruits of Sesbania grandiflora were evaluated for cognition-enhancing activity in high-fat diet-induced dementia in rats using an...
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