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ASSESSMENT OF KNOWLEDGE, ATTITUDE AND PRACTICE IN HYPERTENSIVE PATIENTS IN A TERTIARY CARE TEACHING HOSPITAL
Background: In India, Hypertension is becoming more common and severe, and it is linked to various socio-demographic factors. Many people are ignorant of their illness's severity and the significance of managing it due to a lack of adequate support and education. The first step in developing a preventive program for any health condition is obtaining information regarding the level of awareness. O...
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COMPOUNDS FROM TROPIDIA CURCULIOIDES AS INDUCERS OF APOPTOSIS IN CANCER CELLS
Arunachal Pradesh (AP), the North-eastern state of India, is a natural habitat of 550 species of orchids including 37 species of medicinal importance. Though these plants are used extensively by locals for various ailments, very few scientific investigations have been conducted to establish their pharmacological potential. In the present study, we selected Tropidia curculioides, a relatively unexp...
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DESIGN AND CHARACTERIZATION OF POLYHERBAL FORMULATION FOR HAIR GROWTH CONTAINING ECLIPTA ALBA, HIBISCUS ROSA-SIENSIS, TRIGONELLA FOENUM-GRAECUM LINN.
Gelling agents such as Carbopol 934 and HPMC K 100 were used in different concentrations for the preparation of Topical polyherbal extract gel formulations containing (%w/w) Eclipta alba, Hibiscus rosa-siensis, Trigonella foenum-graecum Linn. Prepared gel extract of various herbal ingredients were characterized by different parameters like gelling capacity, pH, Homogeneity, Grittiness, Extrudabili...
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AN RP-HPLC METHOD FOR THE QUANTITATIVE DETERMINATION OF REMDESIVIR IN INTRAVENOUS DOSAGE FORM
The worldwide epidemic of Coronavirus disease 2019 (COVID-19), caused by a new virus known as severe acute respiratory syndrome (SARS) coronavirus 2, has posed a growing threat to public health (SARS-CoV-2). The only antiviral drug authorized by the FDA for treating adult and pediatric patients hospitalized with a severe disease is remdesivir, which is given intravenously (IV). Although only a few...
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IN-VITRO AND IN-VIVO SYNERGISM BETWEEN VALSPODAR (PSC833) AND ANTIBIOTICS AGAINST STAPHYLOCOCCUS AUREUS STRAINS
Here, we report the in-vitro and in-vivo effects of Valspodar (PSC833), a second-generation mammalian efflux pump inhibitor on the susceptibility of methicillin-resistant and methicillin-sensitive Staphylo-coccus aureus (MRSA and MSSA) towards two antibiotics, Oxacillin (OX) and Cefoxitin (FOX). Checkerboard microdilution assays revealed various degrees of strain-dependent synergy demonstrated in ...
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AN EVALUATION OF THE PROTECTIVE ROLE OF ESCITALOPRAM IN STREPTOZOTOCIN-INDUCED DIABETIC NEUROPATHY
Objective: The aim of the present study was the evaluation of the protective role of escitalopram in streptozotocin-induced diabetic neuropathy. Materials and Methods: Diabetes was induced in Wistar rats with streptozocin 70 mg/kg and animals were divided into four groups namely normal control, diabetic vehicle control, glibenclamide control and escitalopram group. After the 4th week of diabetes...
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CYTOTOXICITY EVALUATION OF MORINGA OLEIFERA (M. OLEIFERA) LAM. FLOWERS ON HUMAN LIVER CANCER CELL LINE AND A. SALINA (BRINE SHRIMP) MODELS
Moringa oleifera Lam is a fast-growing deciduous tree widely cultivated in tropical and sub-tropical regions. All parts of the plant have widely acclaimed nutrition and health-promoting values, but little has been done regarding the toxicity. This study evaluated the safety of different extracts from Moringa flowers using brine shrimp and cell line models. The effect of different concentrations (0...
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A REVIEW ON TRADITIONAL MEDICINAL PLANTS USED AGAINST COMMON NEURO-MUSCULO-SKELETAL DISORDERS IN KARNATAKA STATE, INDIA
Karnataka is a southern state of India with richer diversity of plants and nearly 20% of its land area occupied by forest. Geographically Karnataka state is divided into three major zones, Western Ghats (Sahyadri), Coastal region and the Eastern plains which harbor a diversity of medicinal plants that have been used in traditional medicine by tribes and various ethnic groups for their primary heal...
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DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR ESTIMATION OF VORAPAXAR BY UPLC-MS/MS: APPLICATION TO A PHARMACOKINETIC STUDY
The validated analytical method was applied for estimation of vorapaxar in aqueous and human plasma with vorapaxar-D5 as an internal standard by using UPLC-ESI-MS/MS. The chromatographic separation was achieved with 5mM Ammonium Formate Buffer (pH: 4.0): Methanol: Acetontrile, (40:30:30, % v/v) using the Pursuit XRs-100Å, C18, 4.6 × 50 mm, 10 µm. The total analysis time was 3.5 min and flow rat...
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ASSOCIATION BETWEEN HYPERURICEMIA, SERUM IRON LEVEL AND POSSIBILITY OF GOUT AMONG SAUDI PATIENTS: A RETROSPECTIVE STUDY
The present study has been undertaken to evaluate the association between serum uric acid levels as a marker of iron overload in Saudi people. A retrospective cohort study was carried out at King Fahad Medical City in the Riyadh-central region of the Kingdom of Saudi Arabia for four months from 1st November 2018 to the end of February 2019 on the random sample of 117 medical files for Saudi patien...
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