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REVIEW ON DERIVING A HYPOTHESIS FOR ACHIEVING SUPERIOR BIOAVAILABILITY OF CURCUMIN AS AN ANTITUMOR AGENT
Curcumin, chemically 1,7-bis (4-hydroxy-3-methoxyphenyl) hepta-1,6-diene-3,5-dione derived from Curcuma longa L. is an active chemical constituent used medicinally worldwide from ancient times. Though Curcumin enjoying the reputation of many pharmacological actions, it has certain setbacks with poor bioavailability. The poor water solubility is said to be the reason for poor bioavailability, rathe...
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DETERMINATION OF PHYTOCHEMICAL CONTENTS AND ANTIOXIDANT ACTIVITIES OF ETHANOL EXTRACT OF THE LEAVES OF SCURRULA PARASITICA L.
The phytochemical analysis of ethanol extract of Scurrula parasitica showed positive results for alkaloid, saponins, tannin, terpenoids, flavonoids, phenol, reducing sugar and phytosterols whereas glycoside is found to be absent. Total phenol and flavonoid contents were evaluated and found to be total phenolic compounds (101.9-379.1 µg/g tissue) and total flavonoids (72-174.1 µg/g tissue), respe...
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ANTI-AMNESIC ACTIVITY OF ETHANOLIC FLOWER EXTRACT OF IXORA COCCINEA
Usage of medicinal plants for the treatment of various diseases had been started from 1500 BC onwards. Loss of cognition is one of the age-related mental problems and a characteristic symptom of neurodegenerative disorders like Alzheimer’s. Various natural drugs are used for treatment of Alzheimer’s and Parkinsonism, but Available drugs provide symptomatic treatment with known side effects. So...
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STABILITY STUDY OF NEWLY FORMULATED EMULSION WITH MARKETED FORMULATION
The aim of the article is to formulate and evaluate emulsion also perform comparative study with marketed formulation. Emulsion is a heterogeneous system consisting of at least one immiscible liquid dispersed in another in the form of droplets. Emulsion is prepared with castor oil and liquid paraffin. One marketed formulation was taken for comparison. Identification tests, evaluation tests and sta...
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CITRULLUS COLOCYNTHIS PHYTOSOMES: DEVELOPMENT AND PHYSIOCHEMICAL CHARACTERIZATION
Present work is aimed at development and characterization of phytosomes, novel drug delivery dosage form used to improve the bioavailability of the drug, containing ethanolic, aqueous, dichloromethane and ethyl acetate extract of Citrullus colocynthis to meet the need for better effectiveness and safety. Required phytosomal formulations were developed using different extracts of Citrullus colocynt...
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GREEN SYNTHESIS AND CHARACTERIZATION OF COPPER NANOPARTICLES SYNTHESIZED FROM LAWSONIA INERMIS LEAF EXTRACT
Plant diseases caused by microbial pathogen leads to severe economic loss. Attempt to synthesize nanoparticles for this purpose is an economical and effective means to control these pathogens. For this purpose, nanoparticles synthesized via biological means are not only a safer choice but also a big step towards conservation of the integrity of environmental elements. In the present investigation,...
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EVALUATION OF ANTIOXIDANT PARAMETERS OF MUKIA MADERASPATANA
The present study was an attempt to investigate the effect of extracts and fractions of Mukia maderaspatana on glycemia, lipid profile, lipoprotein level and antioxidant profile in STZ induced diabetic rats for 21 days. Diabetes was induced using streptozotocin (50 mg/kg i.p) and after the induction of diabetes the animals were given with MMEE (100 mg/kg, 200 mg/kg), MMCF (100 mg/kg) and MMBF (100...
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SOLUBILITY ENHANCEMENT AND DEVELOPMENT OF GUM BASED COLON TARGETED DRUG DELIVERY SYSTEMS OF QUERCETIN
The study aimed to enhance the solubility and develop a polymer (Guar Gum/Xanthan gum) based colon targeted drug delivery system of Quercetin promising in-vitro mouth-to-colon release profile. The solubility of the drug was enhanced by the solid dispersion method using solvent-evaporation technique; the optimized formulation 1:5 (Quercetin: PVP) was targeted to colon. Thermal studies proved that t...
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PHARMACOLOGICAL EVALUATION OF ALCOHOLIC EXTRACT OF EUPHORBIA ANTIQUORUM WITH SPECIAL EMPHASIS ON DIABETIC COMPLICATION
Diabetes is a metabolic disorder of carbohydrate, fat and protein metabolism characterized by increased fasting and post prandial blood sugar levels. Diabetes is the most common cause of progressive kidney failure leading to dialysis or transplantation. Nephropathy is reported to develop in 30-40% of patients with diabetes and has become a leading cause of end-stage renal failure worldwide. The va...
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OCULAR INSERTS: A PROMINENT TECHNIQUE FOR OCULAR DRUG DELIVERY
The eye is a sensitive organ, and the administration of drugs into the ocular cavity is a tedious task. Ocular insert is the prominent technique to overcome problems associated with conventional dosage forms like repeated administration, drug drainage via lacrimal fluids drainage, formation of crystalline deposits on the cornea, pH instability, pulsed dosing of drugs, etc. This review focuses on d...
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2007