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GC-MS ANALYSIS OF OIL FROM LAVANDULA LATIFOLIA L. AND ITS REPELLENT ACTIVITY AGAINST MOSQUITO
Mosquitoes are one of the important vectors of various diseases. Repellent activity significantly reduces contact with disease-transmitting mosquitoes. Essential oils have repellent activity that is being potentially developed as an alternative to commercial chemical pesticides. In this study, Lavandula angustifolia was used to evaluate its repellent activity against Ae. Aegypti. The repellent act...
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CURRENT LAWS GOVERNING COMPARATIVE STUDIES AND CLINICAL TRIALS IN INDIA, THE UNITED STATES, EUROPE, AND SINGAPORE
Clinical trials (CTs) are carried out to investigate novel, patient-acceptable, and more effective interventional procedures. Specific regulatory criteria for conducting CTs are recommended by the country's drug regulatory authority, and these guidelines are followed when conducting CTs. The USFDA oversees regulating CTs in the USA in accordance with the Federal Food, Drug, and Cosmetic Act's 21 C...
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IN-VITRO NEUROPROTECTIVE ACTIVITY OF SILIBININ AGAINST MPTP (1-METHYL-4-PHENYL-1, 2, 3, 6-TETRAHYDROPYRIDINE) INDUCED NEUROTOXICITY MODEL
In the present study, we examined the effect of Silibinin on the accumulation of oxidative stress induced by MPTP by in-vitro. After decapitation, healthy rat brain was removed rapidly from the skull and rinsed with cold artificial cerebrospinal fluid (ACSF) which has been equilibrated with 95% O2 / 5% CO2 gas mixture. Group I brain was incubated in CSF serve as normal, Group II lenses brain was i...
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SYNTHESIS AND ANTIMICROBIAL STUDIES OF NOVEL GLYCOSYL THIOCARBAMIDES
Glycosyl isothiocyanates have been widely used as important intermediates in the synthesis of many biologically active glycosyl derivatives. The glycosyl isothiocyanates have been the focus of synthetic attention during recent years because of their potential pharmacological properties. Thiourea and their derivatives are important versatile reagent in organic synthesis and show strong antibacteria...
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SYNTHESIS, CHARACTERIZATION AND ANTITUBERCULAR ACTIVITY OF 6-(ARYL)-2-(SUBSTITUTED METHYL)-4,5-DIHYDRO(2H)PYRIDAZIN-3-ONE DERIVATIVES AGAINST MYCOBACTERIUM TUBERCULOSIS H37RV
Two series of pyridazinone derivatives, 6-(aryl)-2-(substituted methyl)-4,5-dihydro (2H) pyridazin-3-one derivatives (3a-8a and 3b-8b) were synthesized by reacting 6-phenyl substituted 2,3,4,5-Tetrahydro pyridazin-3-one (2a and 2b) with cyclic secondary amine under Mannich reaction conditions. These final compounds (3a-8a and 3b-8b) were characterized by spectral analysis (IR, 1HNMR and mass spect...
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CYTOTOXICITY EVALUATION OF MORINGA OLEIFERA (M. OLEIFERA) LAM. FLOWERS ON HUMAN LIVER CANCER CELL LINE AND A. SALINA (BRINE SHRIMP) MODELS
Moringa oleifera Lam is a fast-growing deciduous tree widely cultivated in tropical and sub-tropical regions. All parts of the plant have widely acclaimed nutrition and health-promoting values, but little has been done regarding the toxicity. This study evaluated the safety of different extracts from Moringa flowers using brine shrimp and cell line models. The effect of different concentrations (0...
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AN RP-HPLC METHOD FOR THE QUANTITATIVE DETERMINATION OF REMDESIVIR IN INTRAVENOUS DOSAGE FORM
The worldwide epidemic of Coronavirus disease 2019 (COVID-19), caused by a new virus known as severe acute respiratory syndrome (SARS) coronavirus 2, has posed a growing threat to public health (SARS-CoV-2). The only antiviral drug authorized by the FDA for treating adult and pediatric patients hospitalized with a severe disease is remdesivir, which is given intravenously (IV). Although only a few...
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IMPACT OF OCT-1 GENETIC VARIATION ON METFORMIN RESPONSE AND ITS GASTROINTESTINAL SIDE EFFECTS
Metformin used successfully by clinicians over the decades as a first-line treatment for hyperglycemia also it was a popular treatment for type-2 diabetes in those who are overweight, when diabetes is not controlled by a healthy diet and lifestyle changes. Genetic factors place an important role in modulating metformin efficacy and toxicity in which OCT- 1 was a major transporter of metformin so g...
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EVALUATION OF ANTI-PARKINSON’S ACTIVITY OF CYAMOPSIS TETRAGONOLOBA METHANOL PLANT EXTRACT WITH BEHAVIORAL AND BIOCHEMICAL ANALYSIS
In the present study, we evaluated the Anti-parkinson’s activity of Cyamopsis tetragonoloba methanol plant pod extract by Haloperidol Induced Catalepsy and Tacrine induced vacuous jaw movements for behavioral parameters and in-vivo assays to estimate neurochemical parameters like (GSH, LPO, and SOD). The behavioral analysis performed using Haloperidol Induced Catalepsy produces Parkinson’s dis...
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SOLUBILITY ENHANCEMENT AND DEVELOPMENT OF GUM BASED COLON TARGETED DRUG DELIVERY SYSTEMS OF QUERCETIN
The study aimed to enhance the solubility and develop a polymer (Guar Gum/Xanthan gum) based colon targeted drug delivery system of Quercetin promising in-vitro mouth-to-colon release profile. The solubility of the drug was enhanced by the solid dispersion method using solvent-evaporation technique; the optimized formulation 1:5 (Quercetin: PVP) was targeted to colon. Thermal studies proved that t...
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