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ANTIMICROBIAL ACTIVITY OF TERMINALIA BELLERICA (GAERTN.) ROXB. AGAINST MULTIDRUG-RESISTANT STAPHYLOCOCCUS SAPROPHYTICUS
The present study investigates the isolation and identification of Multi-Drug Resistant bacteria from Hospital Effluent and the determination of Antimicrobial activity of Terminalia bellerica (Roxb.) against the isolated Multi Drug-Resistant Bacteria. Hospital effluent was collected and screened for the presence of Drug resistance phenotype against five different antibiotics, and the isolated bact...
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SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME COMPOUNDS OF 1,8-NAPHTHYRIDINE-3-CARBOXAMIDE
Various nitrogenous heterocyclic compounds like 1, 8-naphthyridine-3-carboxamide are synthesized and studied for their wide range of biological activity. Versatile activity of this scaffold will increase interest from innovator on significance of their antibacterial activity and will influence their role in drug discovery. Synthesis and Antibacterial evaluation of ten derivatives of 1-ethyl-4-oxo-...
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FORMULATION DEVELOPMENT AND COMPARATIVE EVALUATION OF TRANSDERMAL DELIVERY SYSTEM FOR EFFECTIVE ANTI-EMETIC THERAPY
Transdermal patch or skin patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. Transdermal patches of dolasetron have prepared by the solvent evaporation method using eudragit RL-100: eudragit RS-100 and ethylcellulose: PVP, using different ratios (8:2, 6:4, 5:5), in solvents like ethanol and methanol (1....
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EVALUATION OF PHYTOCONSTITUENTS OF ERIGERON CANADENSIS L. BY FTIR AND GC-MS ANALYSIS
The Nilgiris District is one of the most botanized areas of Southern India. Asteraceae family is one of the largest families consisting of medicinal and aromatic plants in Nilgiris. The chemical compositions of Erigeron canadensis L. plant were investigated using Perkin-Elmer Gas Chromatography-Mass Spectrometry, while the mass spectra of the compounds found in the extract were matched by the Nati...
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A CROSS-SECTIONAL STUDY TO ASSESS PREVALENCE OF PRE-DIABETES AND TYPE 2 DIABETES MELLITUS AND IT’S ASSOCIATED MODIFIED RISK FACTORS IN RURAL COMMUNITY OF GWALIOR DISTRICT
Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder marked by insulin resistance, impaired insulin secretion, and persistent hyperglycaemia. It accounts for over 90% of global diabetes cases and contributes to approximately 9% of global mortality, equating to nearly four million deaths annually. With a rising burden in rural areas, identifying the prevalence and risk factor...
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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF TERTIARY COMBINATIONS OF ANTIHYPERTENSIVE DRUGS: A REVIEW
The most important risk factor for cardiovascular disease is high blood pressure, which accounts for around one-third of those who have it. A majority of those who have hypertension are not on antihypertensive medication. It is not a disease, but it is an important risk factor for cardiovascular disease. Hypertension includes the intricate exchange of natural and pathophysiological factors that in...
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A CRITICAL REVIEW ON THE EFFECT AND TOXICITY OF CADMIUM MEDIATED STRESS IN PLANTS
Cadmium (Cd) is one of the non-essential and highly toxic environmental pollutants. It causes serious environmental and agricultural problems. It ranks seventh on the list of the twenty most toxic metals. Dietary cadmium intake is much higher than the upper limit reported by FAO/WHO. Sources of environmental Cd contamination, soil factors affecting Cd uptake, Cd dynamics in the soil rhizosphere, u...
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QUALITY BY DESIGN APPROACH TO OPTIMIZE OSMOTICALLY CONTROLLED DRUG DELIVERY SYSTEM
The present investigation deals with the development of the controlled porosity osmotic pump (CPOP) tablet of Garcinia indica fruit rind extract used in the management of colon cancer by implementing the concept of Quality by Design (QbD). The quality target product profile (QTPP) and Critical Quality Attributes (CQA) of the Garcinia indica tablets were defined based on preliminary studies. The ef...
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BIOCHEMICAL ANALYSIS AND EVALUATION OF ANTIMICROBIAL PROPERTIES OF THEAFLAVINS AND FLAVONOIDS RICH EXTRACT (TFE) AND ITS SILVER NANOCONJUGATES: A COMPARATIVE STUDY
Black tea, the most widely consumed aromatic non-alcoholic beverage second to water, is prepared by boiling cured leaves of Camellia sinensis. It is reported that black tea contains plenty of bioactive constituents, including complex polyphenols like theaflavins (TF2A, TF2B, TF3) and thearubigins that exhibit a wide range of pharmacological properties and also contribute to its quality and bioacti...
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A REVIEW ON TRADITIONAL MEDICINAL PLANTS USED AGAINST COMMON NEURO-MUSCULO-SKELETAL DISORDERS IN KARNATAKA STATE, INDIA
Karnataka is a southern state of India with richer diversity of plants and nearly 20% of its land area occupied by forest. Geographically Karnataka state is divided into three major zones, Western Ghats (Sahyadri), Coastal region and the Eastern plains which harbor a diversity of medicinal plants that have been used in traditional medicine by tribes and various ethnic groups for their primary heal...
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