Most Popular
A REVIEW ON REGULATORY FRAMEWORK OF RADIOPHARMACEUTICALS IN PHARMACEUTICAL INDUSTRY: CURRENT SCENARIO AND FUTURE ASPECTS
In recent times, the use of radiopharmaceuticals in Medical Imaging and Nuclear medicine has increased. They are a special group of pharmaceuticals with short-shelf life in their final state, and their preparation has been done with utmost care. Due to the inherently hazardous nature of radionuclides on the one hand and the associated concern about radiation safety for patients and staff handling ...
2750
2004
STUDY OF MANGIFERIN ISOLATED FROM LEAVES OF MANGIFERA INDICA ON MYELOID LEUKEMIA ALONG WITH DIFFERENT HUMAN CANCER CELL LINES
In different myeloid leukemia cases resistance to diverse treatment regimen owes to multiple molecular mechanisms of cellular network. Epigenetic dysregulation, gene mutations, overexpression of multidrug resistance genes, abnormal immune function, the presence of chemotherapy-resistant leukemia-initiating cells, and aberrant signaling pathways could be the lead cause of this kind of aberration. S...
2748
1160
ANTIEPILEPTIC ACTIVITY OF RUBIADIN ISOLATED FROM THE ROOTS OF RUBIA CORDIFOLIA IN MICE
Epilepsy is a disorder of the central nervous system. A seizure occurs when the brain’s nerve cells misfire and generate a sudden uncontrolled surge of electrical activity in the brain. Seizures can be controlled with modern medicines and surgical techniques and are found to have so many side effects. Natural products from folk remedies are an alternative source of anti-epileptic drugs with bett...
2747
1451
MOLECULAR VERSUS CONVENTIONAL TECHNIQUES FOR THE DETECTION OF STAPHYLOCOCCUS AUREUS, PSEUDOMONAS AERUGINOSA AND CANDIDA ALBICANS IN NON-STERILE PHARMACEUTICAL PREPARATIONS
Notable progress has been made in methods that encourage the use of PCR as a rapid and accurate tool in quality evaluation of pharmaceuticals. In this study, monoplex and multiplex PCR based assays were developed and compared with standard conventional methods for rapid detection of three specified topical indicator pathogens, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans, in...
2747
1226
DEVELOPMENT AND CHARACTERIZATION OF ORODISPERSIBLE TABLETS CONTAINING PARACETAMOL GRANULES COATED WITH TASTE-MASKING TECHNOLOGY
Orodispersible tablet technology allows tablets to be administered without the need for additional water, which would increase pediatric patient compliance. In this paper, an orodispersible paracetamol tablet formulation with flavor masking technology was developed. For this purpose, the methacrylic acid-derived polymer, Eudragit® E100, has the ability to form films on particles, which are insolu...
2746
1660
DEVELOPMENT AND VALIDATION OF GAS CHROMATOGRAPHY METHOD FOR THE DETERMINATION OF GENOTOXIC IMPURITY, EPICHLOROHYDRIN, IN LINEZOLID DRUG
A sensitive and robust gas chromatography with a flame ionization detector method was developed for the quantification of epichlorohydrin in the linezolid drug substance and validated using guidelines as mentioned in ICH Q2 (R1). Epichlorohydrin was separated on CP-Volamine stationary phase (length 60 m, diameter 0.32 mm, particle size 5 µ) in linear thermal programming using dichloromethane as a...
2744
1567
FORMULATION AND IN-VITRO EVALUATION OF PLGA NANOPARTICLES OF GEFITINIB
The aim of this study was to formulate and evaluate nine formulations of Gefitinib loaded PLGA nanoparticles by homogenization followed by solvent evaporation technique by use of biodegradable and biocompatible polymer i.e. PLGA. The effect of different concentrations of polymer and stabilizer (PVA) on particle size, zeta potential, %EE and drug release was studied. PLGA was used in different conc...
2744
1348
NOVEL RP-HPLC AND UV METHOD DEVELOPMENT AND VALIDATION FOR INOTUZUMAB OZOGAMICIN IN BULK AND ITS PHARMACEUTICAL DOSAGE FORM
A simple, Precise, Accurate method was developed for the estimation of Inotuzumab Ozogamicin by RP-HPLC and UV technique. Chromatographic conditions used were stationary phase Discovery c18 150 × 4.6 mm, 5 m. Mobile phase O- phosphoric acid buffer: Acetonitrile in the ratio of 50v:50v and the flow rate were maintained at 1 ml/min, detection wavelength at 240nm, column temperature was set to 30 º...
2743
1299
COMPARATIVE PHYLOGENETIC ANALYSIS OF METHYLERYTHRITOL-4-PHOSPHATE (MEP) PATHWAY GENES IN ASTERAECAE FAMILY
Stevioside glycosides (SGs) are a class of diterpene glycosides being produced by leaves of Stevia rebaudiana. Stevia is getting agricultural importance due to the production of natural sweetener steviol glycosides, also called as zero-calorie sweeteners. Earlier it was thought that steviol was synthesized from Kaurene via MVA pathway but later on it was concluded that precursors of steviol are ac...
2743
1284
NANONEEDLE MEDIATED NONINVASIVE AND PAINLESS TRANSDERMAL DELIVERY OF INSULIN
We have explored the nanoneedles from nanofabrication techniques, which could penetrate both nuclear and cellular membranes of cells. We received the individual nanoneedles with a tip diameter of 220-250 nm and the desired microscale length ~1 to 100 μm, which enable them for transdermal delivery of selective drug molecule by piercing stratum corneum, the outermost layer of skin. These nanoneedle...
2743
1424