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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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38.

STUDY OF MANGIFERIN ISOLATED FROM LEAVES OF MANGIFERA INDICA ON MYELOID LEUKEMIA ALONG WITH DIFFERENT HUMAN CANCER CELL LINES

In different myeloid leukemia cases resistance to diverse treatment regimen owes to multiple molecular mechanisms of cellular network. Epigenetic dysregulation, gene mutations, overexpression of multidrug resistance genes, abnormal immune function, the presence of chemotherapy-resistant leukemia-initiating cells, and aberrant signaling pathways could be the lead cause of this kind of aberration. S...

H. K. Manikyam

Faculty of Science, Department of Chemistry, North East Frontier Technical University, Aalo, Arunachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5545-52

5545-5552

2750

1162

52.

GREEN SYNTHESIS OF SILVER NANOPARTICLES FROM MUNTINGIA CALABURA FRUIT EXTRACT AND ITS BIOLOGICAL ACTIVITY

Synthesis of silver nanoparticles using fruit extract has been gaining considerable attention as an eco-friendly approach in green chemistry. The present work reports the synthesis of Muntingia calabura silver nanoparticles (McAgNPs) by the addition of an appropriate amount of Muntingia calabura fruit extract to the aqueous AgNO3 solution under constant stirring at room temperature for 24 h. The a...

H. K. Makari, K. Ramakrishna *, G. Vaidya, P. Kulkarni, S. Balija and H. Sheikh

Department of Microbiology, Vijayanagara Sri Krishnadevaraya University, Ballari, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2957-65

2957-2965

2750

1256

51.

ANTIEPILEPTIC ACTIVITY OF RUBIADIN ISOLATED FROM THE ROOTS OF RUBIA CORDIFOLIA IN MICE

Epilepsy is a disorder of the central nervous system. A seizure occurs when the brain’s nerve cells misfire and generate a sudden uncontrolled surge of electrical activity in the brain. Seizures can be controlled with modern medicines and surgical techniques and are found to have so many side effects. Natural products from folk remedies are an alternative source of anti-epileptic drugs with bett...

A. Verma *, V. S. Mahalwal and B. Kumar

Sanskar College of Pharmacy & Research, Ghaziabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(6).3022-28

3022-3028

2749

1452

20.

MOLECULAR VERSUS CONVENTIONAL TECHNIQUES FOR THE DETECTION OF STAPHYLOCOCCUS AUREUS, PSEUDOMONAS AERUGINOSA AND CANDIDA ALBICANS IN NON-STERILE PHARMACEUTICAL PREPARATIONS

Notable progress has been made in methods that encourage the use of PCR as a rapid and accurate tool in quality evaluation of pharmaceuticals. In this study, monoplex and multiplex PCR based assays were developed and compared with standard conventional methods for rapid detection of three specified topical indicator pathogens, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans, in...

R. S. El-Houssieny, M. M. Aboulwafa *, W. F. Elkhatib and N. A. Hassouna

Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

DOI: 10.13040/IJPSR.0975-8232.11(9).4279-92

4279-4292

2749

1227

17.

DEVELOPMENT AND CHARACTERIZATION OF ORODISPERSIBLE TABLETS CONTAINING PARACETAMOL GRANULES COATED WITH TASTE-MASKING TECHNOLOGY

Orodispersible tablet technology allows tablets to be administered without the need for additional water, which would increase pediatric patient compliance. In this paper, an orodispersible paracetamol tablet formulation with flavor masking technology was developed. For this purpose, the methacrylic acid-derived polymer, Eudragit® E100, has the ability to form films on particles, which are insolu...

L. C. A. Laís Costa Ayub *, H. T. T. M. Helena Teru Takahashi Mizuta and V. M. Vinícius Müller

Ourofino Animal Health, Ribeirão Preto, SP – Brazil.

DOI: 10.13040/IJPSR.0975-8232.12(10).5332-40

5332-5340

2748

1660

27.

FORMULATION AND IN-VITRO EVALUATION OF PLGA NANOPARTICLES OF GEFITINIB

The aim of this study was to formulate and evaluate nine formulations of Gefitinib loaded PLGA nanoparticles by homogenization followed by solvent evaporation technique by use of biodegradable and biocompatible polymer i.e. PLGA. The effect of different concentrations of polymer and stabilizer (PVA) on particle size, zeta potential, %EE and drug release was studied. PLGA was used in different conc...

M. Tajmal *, D. Goli and D. P. Venkatesh

Department of Pharmaceutics, Acharya & BM Reddy College of Pharmacy, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2206-10

2206-2210

2746

1348

33.

COMPARATIVE PHYLOGENETIC ANALYSIS OF METHYLERYTHRITOL-4-PHOSPHATE (MEP) PATHWAY GENES IN ASTERAECAE FAMILY

Stevioside glycosides (SGs) are a class of diterpene glycosides being produced by leaves of Stevia rebaudiana. Stevia is getting agricultural importance due to the production of natural sweetener steviol glycosides, also called as zero-calorie sweeteners. Earlier it was thought that steviol was synthesized from Kaurene via MVA pathway but later on it was concluded that precursors of steviol are ac...

T. Saha and S. Chandra *

Department of Bio-Engineering, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India.

DOI: 10.13040/IJPSR.0975-8232.10(9).4293-03

4293-4303

2745

1284

33.

DEVELOPMENT AND VALIDATION OF GAS CHROMATOGRAPHY METHOD FOR THE DETERMINATION OF GENOTOXIC IMPURITY, EPICHLOROHYDRIN, IN LINEZOLID DRUG

A sensitive and robust gas chromatography with a flame ionization detector method was developed for the quantification of epichlorohydrin in the linezolid drug substance and validated using guidelines as mentioned in ICH Q2 (R1). Epichlorohydrin was separated on CP-Volamine stationary phase (length 60 m, diameter 0.32 mm, particle size 5 µ) in linear thermal programming using dichloromethane as a...

D. P. V. V. Devi *, K. M. V. Narayanarao, P. Shyamala, R. M. Krishna and K. S. Prasad

GVK Biosciences, Pvt. Ltd., Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(3).1284-89

1284-1289

2745

1568

26.

NOVEL RP-HPLC AND UV METHOD DEVELOPMENT AND VALIDATION FOR INOTUZUMAB OZOGAMICIN IN BULK AND ITS PHARMACEUTICAL DOSAGE FORM

A simple, Precise, Accurate method was developed for the estimation of Inotuzumab Ozogamicin by RP-HPLC and UV technique. Chromatographic conditions used were stationary phase Discovery c18 150 × 4.6 mm, 5 m. Mobile phase O- phosphoric acid buffer: Acetonitrile in the ratio of 50v:50v and the flow rate were maintained at 1 ml/min, detection wavelength at 240nm, column temperature was set to 30 º...

S. K. Mastanamma *, S. K. Reehana and M. Hari

Department of Pharmaceutical Analysis, University College of Pharmaceutical Science, Acharya Nagarjuna University, Nagarjunanagar, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(6).2845-51

2845-2851

2744

1301

25.

TO EVALUATE THE USE AND SAFETY OF BLOOD THINNING AGENTS IN TERTIARY CARE HOSPITAL

Objective: To ensure the basic principles of drug utilization and the use and safety of blood thinning agents in tertiary care hospital. Experimental design: The study included 224 patients’ and was conducted in a tertiary care hospital and we were focused on to find out the drug-drug interactions of anticoagulants, antiplatelet, and thrombolytic agents, to study the major area involvement for b...

S. S. Jokandan *, D. K. Jha and T. N. Swamy

Department of Pharm D, Karnataka College of Pharmacy, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(7).3332-39

3332-3339

2744

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