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FORMULATION AND IN-VITRO EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF LORNOXICAM
The aim of the present study was to develop a controlled release formulation of Lornoxicam to maintain constant therapeutic levels of the drug for over 12 h. Guar gum, xantham gum, and carbopol 934 were employed as polymers. All the formulations were passed various physicochemical evaluation parameters, and they were found to be within limits. From the dissolution studies, it was evident that the ...
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AN AESTHETIC RECONSTRUCTION OF GROSSLY DECAYED PRIMARY ANTERIOR TEETH – A CASE REPORT
Background: Early childhood caries is a rapidly progressing type of dental caries in children. It can lead to partial or complete loss of crown structure. Grossly decayed anterior teeth often lead to discomfort, and the child may face psychological, aesthetic, functional, and phonetic problems that affect the quality of life of the child, and it poses a challenge for the dentist to preserve the te...
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COMBINED ANTICONVULSANT EFFECT OF NIFEDIPINE AND PENTAZOCINE IN EXPERIMENTALLY INDUCED CONVULSIONS BY ELECTRO CONVULSOMETER IN MICE AND RATS
The present study aimed to investigate the combined anticonvulsant effect of nifedipine (calcium channel blocker) and pentazocine (opioid analgesic) on the duration of convulsions, tonic hind limb extension and recovery in mice and rats. The study was initiated after obtaining ethical approval from the Institutional Animal Ethics Committee (IAEC), Department of Pharmacology, Osmania Medical Colleg...
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INHIBITION OF ISLET AMYLOID POLYPEPTIDE FIBRILLATION BY OKRA SEED EXTRACT-COATED GOLD-NANOPARTICLES
In recent work, an ethanolic extract of okra seeds was successfully conjugated onto gold nanoparticles (AuNPs) via a reduction reaction that has been developed by our laboratory. Because of eliciting antioxidant activity and the presence of g-sitosterol in the extract, such synthesis methodology could be applied. The resulting okra-AuNPs were physically characterized by different methods, includin...
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ISOLATION AND CHARACTERISATION OF ENDOPHYTES FROM MYRISTICA MALABARICA LAM. AND THEIR BIOASSAY
The present investigation was carried out to isolate, characterize, and to study the antagonistic properties of the endophytic microbes from leaves, bark, flower, and fruits of Myristica malabarica. Standard protocols were followed for the isolation and characterization of bacterial and fungal endophytes. Altogether 16 endophytic fungal isolates and three bacterial isolates were isolated from 51 d...
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ANTI-DIARRHEAL AND ANTI-OXIDANT ASSESSMENT OF MIMUSOPS ELENGI LINN. UNRIPEN FRUIT EXTRACTS
The objective of the research was to investigate and evaluate anti diarrheal, antioxidant activity Mimusops elengi Linn. unripen fruit extracts. Mimusops elengi Linn. unripen fruits is considered as one of the best medicinal plants due to its several pharmacological uses mentioned in Unani as well as ethnomedicine. The various extracts of the plant (bark, fruit, leaves, seed, and flowers) have bee...
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DESIGN AND CHARACTERIZATION OF SILVER NANOPARTICLES OF MOMORDICA CHARANTIA LINN. BY GREEN SYNTHESIS
Objective: Present research work describes an eco-friendly and quick method for the development of silver nanoparticles (AgNP) using Momordica charantia Linn. extract and silver nitrate solution. Our investigation reports the antimicrobial activity of developed nanoparticles against Staphylococcus aureus, Escherichia coli. Method: Silver nanoparticle developed by reduction of silver nitrate soluti...
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SUSTAINED RELEASE MULTI-PARTICULATES FORMULATION OF STEREO-SELECTIVE MOLECULE OF KETOPROFEN BY FLUID BED PROCESSOR
The aim is to prepare sustained release multi-particulates dosage form of Dexketoprofen trometamol, which is the active isomer of ketoprofen. Utilization of active moiety with minimum drug dose and administration frequency sustained-release multi-particulates dosage form is explored. Sustained release pellets of the dexketoprofen trometamol were developed by the fluidized bed technology, in which ...
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PHARMACOLOGICAL EVALUATION OF ANTI-DIABETIC EFFECTS OF COMBINED DOSES OF MOMORDICA CHARANTIA AND STEVIA REBAUDIANA AGAINST STZ INDUCED DIABETES MODEL
Diabetes mellitus is one of the most prevalent pathogenic conditions which affect around 6% of the world population. Diabetes mellitus is a systemic metabolic disorder, which is characterized by hyperglycemia, hyperlipidemia, hyperaminoacidemia, and hypoinsulinemia. Although, there are different approaches to minimize the ill effects of diabetes and its complications, herbal formulations are favor...
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PREFORMULATION, FORMULATION DEVELOPMENT AND DRUG RELEASE STUDIES OF DIPYRIDAMOLE FLOATING MICROBALLOONS
For the drugs possessing stomach and upper intestine as the absorption window, it has become high practical importance to improve their gastric residence time. The in vitro performance of the drug delivery being highly variable is ascertaining as gastric emptying is one of the complex mechanisms. Intense researches are being carried out for the development of multiparticulate systems, which are of...
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