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DESIGN, DEVELOPMENT AND FORMULATION OF ECONAZOLE NITRATE CO-CRYSTAL LOADED GEL TO CURE TOPICAL ANTIFUNGAL DISEASE
In the past years many drug discoveries were investigated to be poorly soluble in aqueous medium. These poorly aqueous soluble drugs include Econazole Nitrate (ECZN) having high permeability. ECZN is an effective, potent anti-fungal drug used to cure large range of fungus. Oral administration of ECZN causes gastrointestinal irritation. To overcome or avoid the “first pass metabolism” and to op...
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A NATURAL COUMESTAN WEDELOLACTONE TARGETS INFLAMMATORY CYTOKINES TO INITIATE APOPTOSIS IN HUMAN CERVICAL CANCER CELLS
Objective: Wedelolactone is a naturally (WDL) occurring coumestan of phytoestrogen category that possess anticancer and anti-inflammatory property. In this study, the anti-inflammatory effect of WDL on human cervical cancer cells (HeLa) and initiation of apoptosis mechanism were investigated. Methods: MTT assay and Trypan blue assay were demonstrated to detect the inhibitory effects of WDL on cell...
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STEROL COMPOSITION AND ANTI-ATHEROSCLEROSIS EFFECTS OF XESTOSPONGIA MUTA EXTRACTS BY INCREASING TRANSCRIPTIONAL ACTIVITY OF SR-B1 PROMOTER
Methanolic crude extract, diethyl ether fraction and sterol composition of Xestospongia muta were screened for cytotoxicity activity against HepG2 (liver hepatocellular) cells by MTS assay. Potential sterol mixture was profile using Gas Chromatography-Mass Spectrometry (GC-MS analysis), and luciferase assay were performed to further analyze its potentially on anti-atherosclerosis effects by increa...
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DESIGN AND CHARACTERIZATION OF SOME NEW NON-SYMMETRIC SUBSTITUTED TRIAZINES AND TRIAZINE DERIVATIVES
Attempts were made to carry out the laboratory synthesis of non-symmetric mono-, di- and tri- substituted 1, 3, 5-triazines by the action of the electron-donating substituent on 2, 4, 6-trichloro-1, 3, 5-triazines by aromatic nucleophilic substitution reaction mechanism (SNAr reaction) by temperature controlled. The introduction of the amino group (-NH-), ether (-O-) and thiol (-S-) Linker Bridge ...
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GREEN SYNTHESIS OF SILVER NANOPARTICLES FROM MUNTINGIA CALABURA FRUIT EXTRACT AND ITS BIOLOGICAL ACTIVITY
Synthesis of silver nanoparticles using fruit extract has been gaining considerable attention as an eco-friendly approach in green chemistry. The present work reports the synthesis of Muntingia calabura silver nanoparticles (McAgNPs) by the addition of an appropriate amount of Muntingia calabura fruit extract to the aqueous AgNO3 solution under constant stirring at room temperature for 24 h. The a...
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METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF SOFOSBUVIR AND VELPATASVIR BY UV-VISIBLE SPECTROPHOTOMETRY
A simple, linear, precise, and economical UV spectro-photometric method has been developed for the simultaneous estimation of sofosbuvir and velpatasvir in the bulk and pharmaceutical dosage form. The standard stock solutions were prepared by using methanol as solvent. Estimation of sofosbuvir and velpatasvir was conducted by using a simultaneous equation method based on the measurement of Maximum...
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DESIGN, SYNTHESIS, DOCKING STUDIES AND BIOLOGICAL EVALUATION OF NOVEL HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES AS HISTONE DEACETYLASE ENZYME INHIBITORS
A new series of hydroxamic (5a-5j) and carboxylic acid analogs (4a-4j) based on the 1, 3, 4-thiadiazole scaffold was designed and synthesized to explore its potential as new antitumor agents. The chemical structures of the compounds were confirmed based on TLC, IR, 1H NMR, and 13C NMR analysis. Molecular docking studies showed that the target compounds correctly dock into the binding pocket of his...
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ISOLATION AND STRUCTURE ELUCIDATION OF BIO-ACTIVE COMPOUNDS FROM BOMBAX CEIBA LEAF EXTRACT
Bombax ceiba is a traditional medicinal plant that is beneficial in the treatment of diuretic, hemostatic, antidysenteric, emetic, antipyretic, astringent, and commonly known silk cotton tree, semal, kapok tree. The aim of this study is to isolate and characterize the biologically active compounds from the ethanolic extract of the leaves. The EtOH extract was subjected to silica gel (60-120 mesh) ...
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REVOLUTIONIZING DRUG DEVELOPMENT: THE SYNERGY OF AI AND BIOINFORMATICS IN SHAPING FUTURE THERAPEUTICS- A REVIEW
The combination of bioinformatics and AI improves the precision and productivity of medication development. Artificial intelligence (AI)-powered tools such as AlphaFold and Atomwise speed up the discovery process, and natural language processing (NLP) helps with literature mining and medication repurposing. Advanced approaches such as automated drug testing and quantum computing are also being stu...
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ROLE OF TERPENOIDS AS HEPATOPROTECTIVE
The liver is the most vital organ in our body, involved in several vital functions such as metabolism, secretion, storage as well as detoxification of several drugs and xenobiotic. Liver cell injury caused by various toxic chemicals like certain antibiotics, chemotherapeutic agents, carbon tetrachloride, thioacetamide, excessive alcohol consumption microbes and so, on. Due to liver disease worldwi...
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