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SECONDARY METABOLISMS OF BIOACTIVE COMPOUNDS FROM ACACIA CATECHU STEM BARK METHANOLIC EXTRACT
The main objective of this research work was to check the presence or absence of the phytochemical chemicals in all the selected medicinal plant. Phytochemical analysis of these plants confirm the presence of various phytochemicals like saponins, tannins, amino acids, phenols, carbohydrates, proteins, flavonoids, steroids, alkaloids and glycosides. A. catechu extract are analyzed by using TLC with...
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METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF SOFOSBUVIR AND VELPATASVIR BY UV-VISIBLE SPECTROPHOTOMETRY
A simple, linear, precise, and economical UV spectro-photometric method has been developed for the simultaneous estimation of sofosbuvir and velpatasvir in the bulk and pharmaceutical dosage form. The standard stock solutions were prepared by using methanol as solvent. Estimation of sofosbuvir and velpatasvir was conducted by using a simultaneous equation method based on the measurement of Maximum...
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ANTICANCER ACTIVITY OF EPIPHYLLUM OXYPETALUM (DC.) LEAVES EXTRACT BY IN-VIVO IN-VITRO MODELS
Colon carcinogenesis is a multistep process that arises by the accretion of genetic alterations. The genetic and epigenetic changes which transform normal colonic epithelium into aberrant crypt foci which is responsible for penetration. The GC-MS analysis of ethanolic extract of Epiphyllum oxypetalum (DC.) have shown the presence of phenolic compound (4-hydroxy-2-methylacetophenone), Diterpen...
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A NATURAL COUMESTAN WEDELOLACTONE TARGETS INFLAMMATORY CYTOKINES TO INITIATE APOPTOSIS IN HUMAN CERVICAL CANCER CELLS
Objective: Wedelolactone is a naturally (WDL) occurring coumestan of phytoestrogen category that possess anticancer and anti-inflammatory property. In this study, the anti-inflammatory effect of WDL on human cervical cancer cells (HeLa) and initiation of apoptosis mechanism were investigated. Methods: MTT assay and Trypan blue assay were demonstrated to detect the inhibitory effects of WDL on cell...
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FORMULATION AND EVALUATION OF MATRIX DIFFUSION CONTROLLED TRANSDERMAL DRUG DELIVERY OF HYDRALAZINE HYDROCHLORIDE FOR THE TREATMENT OF HYPERTENSION
In the present study novel matrix diffusion controlled transdermal patches of Hydralazine hydrochloride, a hypertensive drug to ensure satisfactory drug release were successfully prepared by solvent casting method with optimization of suitable polymeric blend of Eudragit L100 (EL-100), ethyl cellulose (EC), polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), carbopol, hydroxypropyl cellulose (HPC...
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EVALUATION OF ANTI-ALZHEIMER’S ACTIVITY OF ALCOHOLIC EXTRACT OF HYLOCEREUS UNDATUS FRUITS IN WISTAR ALBINO RATS
Alzheimer's is a degenerative brain disease associated with memory depletion and mild cognitive dysfunction, leading to dementia. Today's world attempts to treat various ailments have increased with medical advancements. There is still considerable research into medications capable of preventing or at least effectively altering the trajectory of AD. Medicinal plants play a major role in Alzheimer'...
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ROLE OF COMPUTER ASSISTED LEARNING (CAL) AS AN EFFECTIVE TEACHING LEARNING METHOD AND AN ASSESSMENT TOOL IN PRACTICAL PHARMACOLOGY
Background: Pharmacology education has evolved with the introduction of competency-based medical education (CBME). Traditional live animal experiments in pharmacology practical face ethical, logistical, and regulatory challenges. Computer-assisted learning (CAL) using animal simulation software offers an alternative that aligns with CPCSEA guidelines, emphasizing the 4Rs (Reduction, Refinement, Re...
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DESIGN, SYNTHESIS, DOCKING STUDIES AND BIOLOGICAL EVALUATION OF NOVEL HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES AS HISTONE DEACETYLASE ENZYME INHIBITORS
A new series of hydroxamic (5a-5j) and carboxylic acid analogs (4a-4j) based on the 1, 3, 4-thiadiazole scaffold was designed and synthesized to explore its potential as new antitumor agents. The chemical structures of the compounds were confirmed based on TLC, IR, 1H NMR, and 13C NMR analysis. Molecular docking studies showed that the target compounds correctly dock into the binding pocket of his...
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SYNTHESIS AND CHARACTERIZATION OF BENZOCAINE SCHIFF BASE AND ITS COBALT COMPLEX
Ethyl4-(2-hydroxy-benzylideneamino) benzoate Schiff base (C16H15NO3), were synthesized and the structure was studied against the bases of X-ray, UV, visible, elemental analysis, 1HNMR, IR and Mass spectroscopy. The crystal structure of the nickel complex has been determined by single crystal X-ray conformed the molecule, which indicate the compound is crystalline in the monoclinic C2 / c with a = ...
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A COMPARATIVE STUDY TO ASSESS THE EFFICACY OF CLINDAMYCIN WITH TRETINOIN VERSUS CLINDAMYCIN WITH NICOTINAMIDE IN MILD TO MODERATE ACNE VULGARIS
Introduction: Acne is characterized by non-inflammatory follicular papules or comedones and by inflammatory papules, pustules and nodules and is estimated to affect 9.4% of the global population. Topical combination therapy is the first-line approach for facial acne. Objectives: To compare the efficacy and safety of topical clindamycin 1% with tretinoin 0.025% and clindamycin 1% with nicotinamide...
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