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ISOLATION AND STRUCTURE ELUCIDATION OF BIO-ACTIVE COMPOUNDS FROM BOMBAX CEIBA LEAF EXTRACT
Bombax ceiba is a traditional medicinal plant that is beneficial in the treatment of diuretic, hemostatic, antidysenteric, emetic, antipyretic, astringent, and commonly known silk cotton tree, semal, kapok tree. The aim of this study is to isolate and characterize the biologically active compounds from the ethanolic extract of the leaves. The EtOH extract was subjected to silica gel (60-120 mesh) ...
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CARDIOPROTECTIVE EFFECT OF AESCIN ON ANTIOXIDANT AND LIPID PROFILE IN ISOPROTERENOL-INDUCED MYOCARDIAL INFARCTION IN RATS
The efficacy of aescin on the liver and cardiac markers, lipid profile, and antioxidant status in rats with myocardial infarction (MI) induced by isoproterenol (ISO) was investigated in this study. Three doses of aescin (5, 10, and 20 mg/kg of b.w) were administered to rats for the first 21 days. After the treatment period, ISO (60 mg/kg of b.w) was given subcutaneously to the rats on the 22nd and...
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REVITALIZING RATIONALITY THROUGH PDAA CYCLE-A UNION THERAPY CONCEPT
Medicine has been a noble profession since time immemorial. Many cultures have the view that it is linked with the supernatural deity. The persons were priests in many civilizations. They had high status in Society. They were considered as a medium of communication between the supernatural and were assumed to have powers. In those times, those priests used rituals and follow some religious code of...
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A NEW VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF GRAZOPREVIR AND ELBASVIR IN TABLET DOSAGE FORMS
A combination of Grazoprevir and Elbasvir is used to treat Hepatitis C virus (HCV). A selective, accurate and precise RP-HPLC method was developed and validated for the simultaneous estimation of these drugs in combined tablet dosage forms. The drugs were resolved on a BDS C18 column using 0.1% orthophosphoric acid: Acetonitrile (45:55 v/v) as the mobile phase. The detection wavelength was 260 nm....
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DEVELOPMENT AND EVALUATION OF CANDESARTAN CILEXETIL TABLETS USING CRYSTAL AGGREGATES PREPARED BY POLYMER ENRICHED BRIDGING LIQUID
The main objective of the study was to formulate tablets of Candesartan cilexetil using the crystal agglomerates for the enhancement in flow properties and solubility. The crystal agglomerates were prepared by polymer enriched bridging liquid (PEBL) technique. The process requires three solvent systems, the good solvent for the drug, the bad solvent and the bridging liquid. The hydrophilic polymer...
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EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF COLEUS VETTIVEROIDES ROOTS ON EXPERIMENTALLY INDUCED HEPATO TOXIC MODELS
The present study was aimed to assess the hepatoprotective activity of ethanolic extract of Coleus vettiveroides on experimentally induced hepatotoxic models. Phytochemical screening of EECV was carried out and the results showed the presence of carbohydrates, alkaloids, tannin, flavonoids, phenolics, proteins and aminoacid, steroids and triterpenoids. HPTLC screening of EECV was carried out along...
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SPECTROPHOTOMETRIC DETERMINATION OF DRUGS & PHARMACEUTICALS USING N-BROMOSUCCINIMIDE AND RHODAMINE-B COUPLE
Simple, sensitive, and accurate spectrophotometry method one each for estimation of five drugs viz., chloroquine phosphate (CHP), granisetron hydrochloride (GRA), rizatriptan benzoate (RIZ), zoledronic acid (ZOL) and zolmitriptan (ZOT), have been developed. The method depends upon oxidation of each drug by excess N-Bromo succinimide (NS), and subsequent determination of UN reacted NBS by Rhodami...
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EVALUATION OF IN-VITRO ANTHELMINTIC POTENTIAL OF UMBELLIFERONE AGAINST PHERETIMA POSTHUMA
Objective: The present study was aimed to evaluate the in-vitro anthelmintic potential of isolated phytoconstituent umbelliferone against Pheretima Posthuma (Indian earthworm). Methods: Three different concentrations (10, 20, 30 mg/ml in Dimethyl sulfoxide (DMSO) of umbelliferone were prepared, and six worms of similar type were placed in it. Observations were made for the time taken for paralysis...
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DEVELOPMENT OF A LIQUID ORAL IN-SITU GEL OF VORICONAZOLE FOR SUSTAINED RELEASE AND ENHANCED BIOAVAILABILITY: EQUIVALENCE TESTING USING EARTH MOVER’S DISTANCE
Development of a sustained release liquid oral in-situ gel of Voriconazole with improved bioavailability has been the main aim of this project. Complexation of the drug with hydroxypropyl beta-cyclodextrin was done to improve the solubility and stability of the drug. The mucoadhesive polymer carbopol 934P and release retardant HPMC E50 were used as factors and a two-square factorial design was emp...
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IN-VITRO ANTIUROLITHIATIC POTENTIAL OF LEAVES OF EUPHORBIA HIRTA L. AGAINST CALCIUM OXALATE KIDNEY STONES
Plant Euphorbia hirta L. is a common weed plant that belongs to the family Euphorbiaceae characterized by the presence of milky latex in leaves and stems. Phytochemical screening of leaves of Euphorbia hirta L. confirmed the presence of alkaloids, cardiac glycosides, flavonoids, phenolic compounds, tannin and terpenoids. FT-IR confirms the formation of calcium oxalate crystals with major peaks at ...
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