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MODIFIED-RELEASE DOSAGE SYSTEMS DEVELOPED FOR GLIPIZIDE. A REVIEW
In the last decades, diabetes has become one of the most prevalent health concerns worldwide. Diabetes is a metabolic disease that causes hyperglycemia and is associated with altered insulin production (type 1 diabetes) or with insulin-resistance (type 2 diabetes). The present work aims to point out the relevance of glipizide as an alternative treatment for type 2 diabetes and discuss the differen...
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SENSITIVE AND RAPID SIMULTANEOUS QUANTITATION OF RALOXIFENE AND ITS TWO MAJOR ACTIVE METABOLITES 4-GLUCURONIDE RALOXIFENE AND 6-GLUCURONIDE RALOXIFENE IN HEALTHY VOLUNTEERS USING A LIQUID CHROMATOGRAPHY COUPLED WITH TRIPLE QUADRUPLE MASS SPECTROMETER
Simultaneous estimation of parent and its metabolite(s) in a single method poses a threat when one has to monitor one mass transition while running the other compound on liquid chromatography-mass spectrometer. This would again become critical once interference is observed at the retention time of compound of interest in-spite of its absence in the sample. In this paper, a selective and sensitive ...
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BIOSYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDIES OF SILVER NANOPARTICLES USING METHANOLIC EXTRACT OF BULB OF ZEPHYRANTHES CITRINA
In the present study, an eco-friendly, cost-efficient, rapid and simple approach was applied to the synthesis of silver nanoparticles by using a methanolic extract of bulb of Zephyranthes citrina. The metal salt was reduced to ions by metabolites present in bulb extracts. The plant extracts acts both as a reducing agent as well as a capping agent. The synthesized silver nanoparticles were characte...
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USE OF ELECTRON MICROSCOPY IN STUDY OF STEROIDOGENIC CELLS OF NORMAL, REGRESSING AND PREGNANT CAPRINE CORPORA LUTEA
Electron microscopic studies revealed variations in different cell organelles in steroidogenic cells of normal, regressing and pregnant caprine corpora lutea. Corpus luteum was comprised of two types of steroidogenic cells viz. small theca luteal cells and large granulosa luteal cells. In granulosa luteal cells, rough endoplasmic reticulum was most abundant in corpus luteum of pregnancy. The numbe...
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ISOLATION OF CADMIUM DEGRADING MICROORGANISMS FROM ELECTROPLATING, STEEL AND BATTERY INDUSTRY
Increase in industrialization has raised the levels of heavy metal pollution in the country. In order to combat with this problem, many strategies were developed till date, and among them, the use of microorganisms is the most successful technique. The present study was undertaken for isolation, identification, and characterization of heavy metal (Cd) tolerant bacteria from industrial effluents of...
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A STABILITY-INDICATING UV SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF AMOROLFINE HYDROCHLORIDE
A stability-indicating method by UV spectrophotometry has been developed for the specific determination of Amorolfine HCl in bulk in the presence of its degraded products. The method is simple, accurate, precise, and robust. Experiments were designed for determining linearity, the limit of detection and quantitation, accuracy, precision, and specificity of this analytical method as per the Interna...
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ENVIRONMENTAL WELLNESS WITH SPECIAL REFERENCE TO HAEMATOZOAN INFECTION IN REPTILIAN HOSTS
Environment provides a solid platform for good health. An unhealthy environment makes place unsafe for wild animals. One of the effects is a parasitic load on these animals, as a high degree of parasitization may cause harm to the health of these animals. In the present research work, blood parasitic infestation in two species of lizards, Hemidactylus flaviviridis and Calotes versicolor were inves...
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DEVELOPMENT AND IN-VITRO EVALUATION OF LIQUISOLID COMPACTS OF LORNOXICAM
The present study is undertaken with an aim to improve the dissolution profile and availability of a poorly soluble drug, Lornoxicam, through the development of liquisolid tablets. Liquisolid compacts were prepared by employing PEG 400, Avicel PH 112, and Aerosil 200 as solvent, carrier and coating materials, respectively. The flow properties of the drug improved significantly after formulating it...
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SYNTHESIS AND CHARACTERIZATION OF BENZOCAINE SCHIFF BASE AND ITS COBALT COMPLEX
Ethyl4-(2-hydroxy-benzylideneamino) benzoate Schiff base (C16H15NO3), were synthesized and the structure was studied against the bases of X-ray, UV, visible, elemental analysis, 1HNMR, IR and Mass spectroscopy. The crystal structure of the nickel complex has been determined by single crystal X-ray conformed the molecule, which indicate the compound is crystalline in the monoclinic C2 / c with a = ...
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FTMS-ESI CHARACTERISATION OF ETHER EXTRACT OF AZADIRACHTA INDICA LINN. OBTAINED FROM ANANTHAPURAM ANDHRA PRADESH INDIA
Neem (Azadirachta indica) is a member of the Meliaceae family and its role as the health-promoting effect is attributed because it is a rich source of potent biochemicals. It has been widely used in Chinese, Ayurvedic, and Unani medicines worldwide especially in Indian Subcontinent in the treatment and prevention of various diseases. In this present study’s author being investigated and identifi...
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