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AN UPDATE ON POTENTIAL THERAPEUTIC ACTIONS OF BOSWELLIC ACIDS
In recent years, natural products such as Boswellic acids (BAs) have attracted researchers around the globe because of their significant potential against various diseases without any toxic effects. Boswellic acids, which belong to the pentacyclic triterpenes type of class, are extracted from the gum-resin portion of Boswellia serrata and many other different species such as Boswellia sacra, Boswe...
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AN OLD ADAGE MANAGEMENT PERSPECTIVE FOR DANDRUFF
Dandruff is a well-known and global consumer problem, characterized by flaking and scaling of the scalp, with itching and irritation. Although it is not a life-threatening disease, but it is directly related to individual self-esteem, confidence, and beauty. Approximately half of the population is suffering from dandruff and expending around billions of dollars, including hospital services and cou...
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A REVIEW ON CHROMEN DERIVATIVES AS ANTIEPILEPTICS
Chromens are oxygen-containing heterocycles, abundantly found in nature in the form of flavone, is flavones, flavanones, catechins, anthocyanins and collectively known as flavonoids and isoflavonoids. Being a polar and ionizable aromatic compound, it improves the pharmacokinetic characteristics of lead molecules. Imidazole derivatives have occupied a unique place in the field of medicinal chemistr...
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REVOLUTIONIZING DRUG DEVELOPMENT: THE SYNERGY OF AI AND BIOINFORMATICS IN SHAPING FUTURE THERAPEUTICS- A REVIEW
The combination of bioinformatics and AI improves the precision and productivity of medication development. Artificial intelligence (AI)-powered tools such as AlphaFold and Atomwise speed up the discovery process, and natural language processing (NLP) helps with literature mining and medication repurposing. Advanced approaches such as automated drug testing and quantum computing are also being stu...
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DRUG UTILIZATION STUDY IN INDOOR ADULT POST-OPERATIVE PATIENTS OF GENERAL SURGERY UNIT OF A TERTIARY CARE TEACHING HOSPITAL OF CENTRAL INDIA – A PROSPECTIVE OBSERVATIONAL STUDY
Background: Drug Utilization Study offers useful methods for teaching and training in drug therapy. In our setting, there is no such study that describes the use of drugs post-operatively. As a result, this study was conducted to investigate the post-operative drug utilization pattern in indoor post-operative patients. Aim: To study the prescribing trends of drugs used in indoor adult post operati...
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DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL QUINOLINE ANALOGUES AS HIV-1 INTEGRASE INHIBITOR
A progression of fourteen narrative quinolonyl diketo acid analogs were planned, synthesized, identified by IR, NMR, CHN and MS supernatural analysis and evaluated as potential HIV-1 Integrase hinders. Compounds of Zinc database were surfed considering Elvitegravir as standard. Nearly 99 compounds were identified and docked in the active site of HIV-1 integrase. Molecular docking study of compound...
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IN-VITRO ANTIOXIDANT PROPERTIES OF DELONIX ELATA WHOLE PLANT EXTRACTS
Delonix elata (D. elata) whole plant was chosen to evaluate in-vitro anti-oxidant activities. The total polyphenols and flavonoids were determined after the extraction. DPPH (2, 2'-diphenyl-1-picrylhydrazy), H2O2 (Hydrogen peroxide), NO (Nitric oxide) and TBARS (Thiobarbituric acid) methods were used to evaluate antioxidant activities of D. elata whole plant. The results showed that the highest le...
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DEVELOPMENT AND EVALUATION OF MOXIFLOXACIN HYDROCHLORIDE LOADED POLY LACTIC-CO-GLYCOLIC ACID NANOPARTICLES FOR OCULAR DRUG DELIVERY
In general, ocular efficacy is strongly related to ocular drug bioavailability, which may be enhanced by prolonging precorneal drug residence time and increasing corneal drug penetration. Hence, the present study involves the development, characterization and evaluation of biodegradable moxifloxacin hydrochloride nano-particles intended for ocular use. Nano-particles were prepared by nano-precipit...
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DEVELOPMENT AND CHARACTERIZATION OF MANNOSYLATED QUERCETIN LOADED LIPOSOMES FOR SKIN CARCINOMA
The solar UV radiation is the major trigger factor that causes skin cancer. Nearly 65% of cases of melanoma occurs dues to high exposure to the UV radiation. It also accounts for 90% of the nonmelanoma skin cancers also referred to as NMSC also including the cases of basal cell carcinoma (BCC) and the squamous cell carcinoma (SCC). The rate of malignancy in other cases has seemed to get reduced bu...
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ALPHA-AMYLASE INHIBITION AND MEMBRANE STABILIZING EFFECT OF THE STEM BARK OF MAESOBOTRYA DUSENII HUTCHINSON
Introduction: Control of blood glucose level is a critical approach in the management of diabetes mellitus and its complications. This study investigated the α-amylase inhibition and erythrocyte membrane stabilization effect of extracts of Maesobotrya dusenii Hutch. Method: Powdered stem bark of M. dusenii (100g) was extracted with methanol. The plant material (400g) was also successively macerat...
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