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GC-MS AND FT-IR ANALYSIS OF METHANOL FRUIT EXTRACT OF FICUS RACEMOSA AND FICUS AURICULATA
The fruits of the plant Ficus racemosa and Ficus auriculata are consumed as a wild edible fruit and have also been used extensively in traditional medicine to treat various illnesses ranging from diarrhea, dysentery, jaundice to diabetes, piles, asthma, and urinary diseases. Gas Chromatography-Mass Spectro-metry (GC-MS) analysis of methanol extract of the fruits was carried out to identify the pos...
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CANCER-ASSOCIATED THROMBOSIS: AN OVERVIEW OF THROMBOSIS MECHANISMS AND ITS RISK FACTORS IN CANCER
Thrombosis is one of the major causes of death and disability worldwide. Cancer patients are commonly thrombophilia or prothrombotic since they have abnormalities in all three factors of Virchow's triad, which lead to thromboembolism. Venous thrombosis (VT) is a chronic disorder that has the potential to be fatal and cause considerable complications. Venous thromboembolism (VTE) may potentially be...
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DESIGN AND OPTIMIZATION OF EXPANDABLE GASTRORETENTIVE PATCH OF METRONIDAZOLE FOR HELICOBACTER PYLORI INFECTION MANAGEMENT
The aim of the present research was to develop and optimize novel expandable gastro retentive formulation of metronidazole to give local action for the management of Helicobacter pylori infection. The formulation contained a drug-loaded sandwich patch prepared by solvent casting method folded into a hard gelatin capsule. Metronidazole being needle shape crystals soluble in 0.1 N HCl, but after dry...
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THE IMPACT OF CARCINOGENIC CHEMICAL USE AMONG CARDAMOM FARMERS AND THE PREVALENCE OF CANCER IN IDUKKI DISTRICT, KERALA
The prevalence of cancer is drastically increasing among cardamom farmers using chemical pesticides in Idukki district. The chemicals, mainly Organochlorine and organophosphates, result in various disease conditions. The main aim of the study was to explore the prevalence of cancer and other disease conditions among farmers and other people who were exposed to chemical pesticides. A community-base...
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QUANTITATIVE DETERMINATION OF LACOSAMIDE IN HUMAN PLASMA USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY AND ITS APPLICATION TO PHARMACOKINETIC STUDY
A simple, reliable, and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the determination of lacosamide, an antiepileptic drug, in human plasma. The lacosamide and internal standard (IS) have been extracted by a simple liquid-liquid extraction method and separated on C18 (50 × 4.6 mm, 5μm) column with the mobile phase of 5mM ammoniu...
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PHENOLIC ACID DERIVATIVES AS PRESERVATIVES: SYNTHESIS, ANTIOXIDANT, ANTIMICROBIAL POTENTIAL AND THEIR PRESERVATIVE EFFECTIVENESS
Natural phenolic acids alkyl esters viz methyl, ethyl, propyl was synthesized and characterized by spectral means FTIR, 1HNMR, and 13CNMR. All the synthesized esters were examined for their antimicrobial potential, preservative efficacy and antioxidant potential. Among the synthesized ester derivative caffeic acid and gallic acid, derivatives were displayed excellent antioxidant and antimicrobial ...
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ROLE OF TERPENOIDS AS HEPATOPROTECTIVE
The liver is the most vital organ in our body, involved in several vital functions such as metabolism, secretion, storage as well as detoxification of several drugs and xenobiotic. Liver cell injury caused by various toxic chemicals like certain antibiotics, chemotherapeutic agents, carbon tetrachloride, thioacetamide, excessive alcohol consumption microbes and so, on. Due to liver disease worldwi...
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APPLICATION OF NANOTECHNOLOGY FOR TREATMENT OF ANGINA PECTORIS AS CARDIOVASCULAR DISEASE: A REVIEW
Angina Pectoris is the medical term for chest pain or discomfort due to coronary heart disease. The drawback of the marketed formulation is required repeated administration of the drug due to low bioavailability. Therefore, it utilized a nanotechnology technique for prevention of drawback of marketed formulation. Polymeric nanoparticles have been in preferential list when it comes to nano-drug del...
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SOLUBILITY ENHANCEMENT AND DEVELOPMENT OF GUM BASED COLON TARGETED DRUG DELIVERY SYSTEMS OF QUERCETIN
The study aimed to enhance the solubility and develop a polymer (Guar Gum/Xanthan gum) based colon targeted drug delivery system of Quercetin promising in-vitro mouth-to-colon release profile. The solubility of the drug was enhanced by the solid dispersion method using solvent-evaporation technique; the optimized formulation 1:5 (Quercetin: PVP) was targeted to colon. Thermal studies proved that t...
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EFFECTS OF ORAL ZINC SUPPLEMENTATION IN EARLY NEONATAL LIVE ON DEVELOPMENT OF OBESITY AND METABOLIC SYNDROME IN ALBINO RATS
Background: Zinc (Zn) is the most common trace element in eukaryote cells and the second most abundant trace element in human tissues and secretions after iron. Zinc is required for normal growth and development from in uteri to puberty. There is a lack of evidence on Zn as a potential therapeutic agent to reduce weight and improve metabolic parameters in obese adults. Aim: to evaluate Zn suppleme...
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