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DEVELOPMENT AND EVALUATION OF CANDESARTAN CILEXETIL TABLETS USING CRYSTAL AGGREGATES PREPARED BY POLYMER ENRICHED BRIDGING LIQUID
The main objective of the study was to formulate tablets of Candesartan cilexetil using the crystal agglomerates for the enhancement in flow properties and solubility. The crystal agglomerates were prepared by polymer enriched bridging liquid (PEBL) technique. The process requires three solvent systems, the good solvent for the drug, the bad solvent and the bridging liquid. The hydrophilic polymer...
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SELECTIVE ISOLATION AND CHARACTERIZATION OF NOCARDIOPSIS FLAVESCENS VJMS-18 FROM COASTAL REGIONS OF ANDHRA PRADESH, INDIA
Objective: To evaluate the antimicrobial potential of Nocardiopsis flavescens isolated from the marine environment. Methods: Attempts were made to isolate actinomycete strains from marine coastal regions of Andhra Pradesh, India. The soil samples collected were pre-treated with calcium carbonate, diluted and plated on three different media to isolate actinomycetes. All the isolates were screened f...
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MOLECULAR DOCKING STUDIES OF A FEW NOVEL PYRIMIDINE DERIVATIVES AS REVERSE TRANSCRIPTASE HIV-1 INHIBITORS
Anti-HIV drug discovery has been increasingly focusing on HIV-1- reverse transcriptase as a potential therapeutic target. Pyrimidine-based derivatives are studied for their HIV-1 reverse transcriptase inhibition activities using in-silico techniques. The library of 19 pyrimidine-based derivatives designed using computer-based molecule designed software and docked with HIV-1 reverse transcriptase e...
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IN-VITRO ANTIUROLITHIATIC POTENTIAL OF LEAVES OF EUPHORBIA HIRTA L. AGAINST CALCIUM OXALATE KIDNEY STONES
Plant Euphorbia hirta L. is a common weed plant that belongs to the family Euphorbiaceae characterized by the presence of milky latex in leaves and stems. Phytochemical screening of leaves of Euphorbia hirta L. confirmed the presence of alkaloids, cardiac glycosides, flavonoids, phenolic compounds, tannin and terpenoids. FT-IR confirms the formation of calcium oxalate crystals with major peaks at ...
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QUALITY BY DESIGN (QbD) BASED APPROACH FOR DEVELOPMENT OF FAST DISSOLVING TABLETS
Background: Oral disintegrating tablets are strong dosage forms comprising medications that disintegrate throughout the oral cavity in less than 1 minute. Quality by designis a modern approach to pharmaceutical quality. Pharmaceutical Quality Design and discusses the use of Quality Design to maintain the quality of Pharmaceuticals. Methods: The frequent screening design, such as 32 factorial desig...
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DEVELOPMENT OF A LIQUID ORAL IN-SITU GEL OF VORICONAZOLE FOR SUSTAINED RELEASE AND ENHANCED BIOAVAILABILITY: EQUIVALENCE TESTING USING EARTH MOVER’S DISTANCE
Development of a sustained release liquid oral in-situ gel of Voriconazole with improved bioavailability has been the main aim of this project. Complexation of the drug with hydroxypropyl beta-cyclodextrin was done to improve the solubility and stability of the drug. The mucoadhesive polymer carbopol 934P and release retardant HPMC E50 were used as factors and a two-square factorial design was emp...
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HAEMOTOXICITY OF LEAD (Pb) ON THE BLOOD PARAMETERS OF FRESH WATER TELEOST HETEROPNEUSTES FOSSILIS (BLOCH)
Blood parameters are important indicators for assessing the health status of living organisms subject to changing environment. Blood parameters (Hb%, TEC, TLC, ESR, PCV, MCH, and MCV) of Heteropneustes fossilis exposed to lead were investigated at different time intervals. Acclimatized specimens were divided into four groups: Group-A (Control), Group-B (2.25 ppm), Group-C (2.65 ppm), Group-D (2.85...
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DNA SEQUENCING, MUTATIONAL ANALYSIS OF NOVEL COMT GENE VARIANTS AND ITS PATHOGENICITY IN SCHIZOPHRENIA PATIENTS: ACROSS-SECTIONAL STUDY FROM TUMKUR DISTRICT OF SOUTH KARNATAKA
Introduction: Schizophrenia is a multi-factorial neuropsychiatric disorder, influenced by environmental and genetic factors. The catechol-O-methyltransferase (COMT) gene is a crucial for the metabolism of dopamine. It has been thoroughly investigated for its potential role in SCZ. At the same time; several variants in the COMT gene have been reported in diverse populations in South Karnataka but r...
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GC-MS INVESTIGATION OF PHYTOCOMPONENTS PRESENT IN ETHANOLIC EXTRACT OF PLANT ICHNOCARPUS FRUTESCENS (L.) W. T. AITON AERIAL PART
Ichnocarpus frutescens (Apocynaceae) generally renowned as Kali Sariva in Sanskrit, Krishna Sariva in Hindi which is a large, evergreen, red woody climber, native to India, Java, China, Southeast Asia, Ceylon, Northern Australia and found ascending to an altitude of 4,000 ft. Different tribes of India are used this plant as a substitute of Indian Sarsaparilla (Hemidesmus indicus). It has been used...
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EVALUATION OF IN-VITRO ANTHELMINTIC POTENTIAL OF UMBELLIFERONE AGAINST PHERETIMA POSTHUMA
Objective: The present study was aimed to evaluate the in-vitro anthelmintic potential of isolated phytoconstituent umbelliferone against Pheretima Posthuma (Indian earthworm). Methods: Three different concentrations (10, 20, 30 mg/ml in Dimethyl sulfoxide (DMSO) of umbelliferone were prepared, and six worms of similar type were placed in it. Observations were made for the time taken for paralysis...
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