Most Popular
ANTIOXIDANT AND ANTIMICROBIAL ACTIVITY OF SECONDARY METABOLITE PRODUCED BY ENDOPHYTIC FUNGI ISOLATED FROM LANNEA COROMANDELICA (HOUTT.) MERR
Lannea coromandelica (Houtt.) Merr. which is known as Kayu Jawa in Bugis community, Indonesia has been widely used empirically for the treatment of wounds. Ethanol extract from its stem bark is known to have antibacterial, anti-inflammation, and antioxidant activity. The purpose of this study were to isolate, characterize, and determine the antioxidant and antimicrobial activity of the endophytic ...
1358
640
BIOLOGICALLY SYNTHESIZED SILVER NANOPARTICLES OF CURCUMA CAESIA ROXB. RHIZOME EXTRACT AND EVALUATION OF THEIR ANTIBACTERIAL ACTIVITY AGAINST MDR BACTERIA
Multidrug-resistant (MDR) bacterial infection is severe health concerns in the field of medicine. The researcher used green synthesized silver nanoparticles to overcome from MDR bacterial infection. Present study revealed successful synthesis of nanoparticles from Curcuma caesia aqueous rhizome extract by use of silver metal as a capping agent. Synthesized silver nanoparticles were identified by v...
1356
602
SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR DETERMINATION OF GRANISETRON HYDROCHLORIDE IN BULK AND INJECTIONS
The present UV Spectrophotometric and RP-HPLC method was simple, accurate, precise, specific, and sensitive. Spectrophotometric method was developed in water and very useful for analysis of bulk drug and injection formulation. RP-HPLC method was developed in Phosphate buffer (pH 3.0 adjusted with orthophosporic acid) and acetonitrile (70:30) using column HiQsil C18 column (250 × 4.6 mm; 5 μm...
1356
732
A STATE OF THE ART REVIEW ON SELF EMULSIFYING DRUG DELIVERY SYSTEM
Solubility plays a vital role in achieving the therapeutic efficacy of a drug from a dosage form. Advances in molecular screening techniques for identification of potential drug molecules investigated an increased number of new pharmacologically active lipophilic compounds that are poorly water-soluble about 40% of new chemical entities have been discovered as poorly water-soluble. Numbers of tech...
1354
552
QUALITY BY DESIGN (QbD) APPROACH FOR METHOD DEVELOPMENT FOR AZILSARTAN MEDOXOMIL USING UPLC: APPLICATION TO HYDROLYTIC, THERMAL AND OXIDATIVE DEGRADATION KINETICS
Quality by Design (QbD) is a systematic approach for the development of products and processes. Azilsartan Medoxomil is a competitive antagonist of the Angiotensin II Type 1 receptor. A precise and reproducible ultra-performance liquid chromatographic (UPLC) method was developed and validated for the estimation of Azilsartan Medoxomil from its marketed tablet dosage form applying Quality by Design...
1353
1045
A COMPARATIVE SOLUBILITY ENHANCEMENT AND DISSOLUTION STUDY OF RANOLAZINE USING DIFFERENT TECHNIQUES
The aim of the present study was to enhance the solubility of the poorly soluble drug Ranolazine. Solid dispersions were prepared using PVP K-30 and PEG 4000 & 6000 by melting, solvent evaporation using varying polymer ratios (1:1, 1:2, 1:3, 1:4). The prepared formulations were characterized for saturation solubility, IR, PXRD, SEM. The aqueous solubility of Ranolazine was favored by the prese...
1353
769
STABILITY INDICATING LC-ASSAY METHOD FOR METFORMIN HYDROCHLORIDE AND TENELIGLIPTIN HYDROBROMIDE FROM TABLET FORMULATIONS
A simple, rapid, accurate, robust, and specific HPLC method was developed for the assay of metformin hydrochloride and teneligliptin hydrobromide from the oral tablet formulations. Stability-indicating reverse-phase chromatographic method was developed on a RP C18 column (250 mm × 4.6 mm, 5µm) using a mixture of 20 mM ammonium acetate of pH 5.5 and methanol in the ratio 50:50 v/v as mobile phase...
1351
748
DEVELOPMENT AND CHARACTERIZATION OF MICROSPONGE GEL FOR TOPICAL DELIVERY OF OREGANO OIL
Oregano oil is an essential oil possessing anti-inflammatory, antioxidant, antimicrobial, and immune-boosting properties that can be used in the treatment of various skin disorders. However, its practical applications are limited due to its handling issues and poor stability in the presence of air, light, and high temperature. To overcome these problems, this study aims to entrap oregano essential...
1350
710
PEPTIC ULCEROGENESIS: ETIOLOGY, PATHOGENESIS AND VARIOUS CLINICAL ASPECTS
“Eat to live and don’t live to eat” this is a principle to be followed for a healthy and wealthy life. According to the therapeutic point of view, the patient who suffers from peptic ulcer diseases was shown to have a reduced secreted amount of HCl and pepsin. The management of gastric and duodenal ulcers can be followed by the decreased or neutralized level of gastric acid. Peptic ulcer inf...
1349
635
DESIGN AND OPTIMIZATION OF EXPANDABLE GASTRORETENTIVE PATCH OF METRONIDAZOLE FOR HELICOBACTER PYLORI INFECTION MANAGEMENT
The aim of the present research was to develop and optimize novel expandable gastro retentive formulation of metronidazole to give local action for the management of Helicobacter pylori infection. The formulation contained a drug-loaded sandwich patch prepared by solvent casting method folded into a hard gelatin capsule. Metronidazole being needle shape crystals soluble in 0.1 N HCl, but after dry...
1347
609