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A COMPARATIVE SOLUBILITY ENHANCEMENT AND DISSOLUTION STUDY OF RANOLAZINE USING DIFFERENT TECHNIQUES
The aim of the present study was to enhance the solubility of the poorly soluble drug Ranolazine. Solid dispersions were prepared using PVP K-30 and PEG 4000 & 6000 by melting, solvent evaporation using varying polymer ratios (1:1, 1:2, 1:3, 1:4). The prepared formulations were characterized for saturation solubility, IR, PXRD, SEM. The aqueous solubility of Ranolazine was favored by the prese...
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ANTIBACTERIAL ACTIVITY OF SOME COMMON KITCHEN SPICES AGAINST ESCHERICHIA COLI, STAPHYLOCOCCUS AUREUS, SALMONELLA TYPHIAND PSEUDOMONAS AERUGINOS
The current study investigated and compared the antibacterial activity of common kitchen spices; Ginger, Turmeric, Bay leaf, and Coriander, against Escherichia coli, Staphylococcus aureus, Salmonella Typhi, and Pseudomonas aeruginosa. The antibacterial activity of different spices was calculated by the agar well cup plate method. The concentrations, 75%, 50%, and 25%, were made for all the test sp...
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HYDROXYCHLOROQUINE (HCQ) AS AN EMERGING AND PROMISING DRUG CANDIDATE IN COVID-19 PANDEMIC – A SYSTEMATIC REVIEW
Hydroxychloroquine (HCQ) belongs to the class of 4-aminoquinolines. It is a hydroxylated version of chloroquine with a similar mechanism of action but rather a safe profile. It is primarily an antimalarial drug but has been extensively used for treating rheumatoid arthritis, porphyria, discoid and systemic lupus erythematosus as well. Most recently, this drug has found a place in the treatment of...
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HYDROCOTYLE SIBTHORPIODES EXTRACT LOADED IN CHITOSAN NANOCAPSULE AS AN EFFECTIVE ANTIBACTERIAL AGENT AGAINST FEW PREVALENT MICROBES IN WOUND
Hydrocotyle sibthorpiodes is a known medicinal plant and is used for treatment against many bacterial and fungal pathogens in a conventional application form. The present study was intended to enhance the activity of H. sibthorpiodes plant extract against four bacterial species in combination with clove oil and silver nanoparticles by preparing a chitosan based nanocapsule that cause chronicity in...
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INHIBITORY EFFECT OF ETHANOL EXTRACT OF MELASTOMA MALABATHRICUM LEAVES ON INFLAMMATORY SPLA2 ENZYME AND ITS ABILITY TO REDUCE THE CELL VIABILITY OF PC3 CELL LINE
Melastoma malabathricum is a medicinal plant found throughout Southeast Asian countries. Traditionally M. malabathricum was used for treating diseases such as hemorrhoids, cuts and wounds, toothache, and stomachache. Scientific findings also revealed the wide pharmacological actions of various parts of M. malabathricum such as anti-nociceptive, anti-inflammatory, wound healing, anti-diarrheal...
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REVIEW ON ROLE OF NUTRACEUTICALS IN STRESS MANAGEMENT
Stress is a complicated process that affects everyone differently. When the body is exposed to stressors, it initiates a series of coordinated responses called "stress responses," which include behavioral changes, immunological regulation, hormone release, and various physiological changes. Stress is the physiological response to risk or pressure, and it displays physically as fatigue or energy lo...
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CLINICAL EVALUATION OF EFFICACY OF MUNḍIJ AND MUSHIL THERAPY IN THE MANAGEMENT OF RHEUMATOID ARTHRITIS
Objective: To study the anti-arthritic effect of a Unani regimen comprising of Munḍij wa Mushil therapy along with Habb-e-Gul-e-Aak and to propose a safe and alternative therapy for RA. Materials and Methods: In this clinical trial, 30 diagnosed patients of RA fulfilling the inclusion and exclusion criteria were recruited and randomly distributed into two groups A&B with 20 patients in the t...
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THE APPLICATION OF ULTRASOUND IRRADIATION AS AN ALTERNATIVE METHOD FOR THE PREPARATION OF 99mTc-OCTREOTIDE RADIO COMPLEX
This approach was launched to evaluate the application of ultrasound waves for the preparation of 99mTc-Octreotide radio conjugate sample. The 740MBq (20 mCi) of 99mTc-Octreotide samples were prepared by the boiling water bath (standard) or ultrasound irradiation methods. The stability of samples in normal saline and human serum albumin was investigated. The partition coefficient and protein bondi...
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DEVELOPMENT AND VALIDATION OF UV-SPECTROSCOPIC METHOD FOR THE ESTIMATION OF LYMECYCLINE IN CAPSULE DOSAGE FORM
Lymecycline is a tetracycline broad-spectrum antibiotic. Present work describes a simple, accurate, precise, economical and reproducible spectrophotometric method in ultraviolet region has been developed and validated for the assay of Lymecycline in bulk and in Pharmaceutical formulations in diluent. Lymecycline is a tetracycline broad-spectrum antibiotic. Lymecycline like other tetracyclines is u...
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DEVELOPMENT AND INVESTIGATION OF EUDRAGIT S-100 ENCAPSULATED CHITOSAN COATED LIPOSOMES OF PREDNISOLONE FOR COLON TARGETING
The objective of the study was to formulate coated liposomes containing Prednisolone for colon targeting and localization of the therapy to the inflamed colon mucosa. Liposomes were prepared using thin film hydration method. Liposomal formulations were optimized using 32 factorial design using varying concentrations of SPC and cholesterol as independent variables and % EE as the dependent variable...
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