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THE HEPATIC CYP3A4 UPREGULATED INCREASED METABOLISM IN RESPONSE TO PHYSICAL ACTIVITY AT HIGH ALTITUDE
The present study was designed to assess the pharmacokinetics of drug metabolized by hepatic cytochrome 3A4 (CYP3A4) in human volunteers with physical activity at the high altitude hypobaric hypoxic environment. The International Physical Activity Questionnaire short form 7 (IPAQ SF-7) was used to measure the physical activity. The total of 24 healthy male volunteers participated in this study; fo...
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IN-VITRO AND IN-VIVO QUANTITATIVE ESTIMATION OF TOTAL PHENOLS, ASCORBIC ACID CONTENT AND ANTIOXIDANT ACTIVITY IN NORMAL FLOWER AND FLOWER GALL OF CRATAEVA RELIGIOSA
Plant galls are remarkable close associations between plants and insects, in which the plant produces an abnormal growth of tissue in response to a specific stimulus from the attacking insect. The present investigation was undertaken to assess the antioxidant activity as well as the total phenols and ascorbic acid content in in-vivo (normal flower and galled flower) and in-vitro (unorganized stati...
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THERAPEUTIC EFFECT OF MORINGA OLEIFERA LEAF EXTRACTS ON OXIDATIVE STRESS AND KEY METABOLIC ENZYMES RELATED TO OBESITY
Obesity ailments, commonly known as “New World Syndrome,” has drawn the attention of the scientific community to explore novel natural product-based therapeutics as effective alternatives. In this study, different solvent extracts of Moringa oleifera (M. oleifera; Drumstick tree) leaves were prepared, and their phytochemical analysis was done. The therapeutic effect of M. oleifera leaf extra...
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FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF ONDANSETRON HYDROCHLORIDE
Ondansetron hydrochloride (ONH) is an exceptionally harsh, powerful antiemetic drug utilized for the treatment and prophylaxis of chemotherapy or radiotherapy or postoperative prompted emesis. This investigation aims to detail and assesses taste-covered quick-dissolving tablets (FDTs) of ONH to expand patient consistence. ONH taste veiled granules were set up by a strong scattering procedure. Diss...
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3D PRINTING IN PHARMACEUTICALS A COMPREHENSIVE REVIEW ON A NOVEL EMERGING TECHNOLOGY
Three-dimensional printing (3DP) is an emerging technology that allows the fabrication of tailor-made drugs, devices, and organs that meet an individual patient's requirement. Thus, it has enormous potential to bring about a significant transformation in the pharmaceutical and healthcare sector. 3DP involves the production of structures with desired design by deposition of printing material in a l...
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ISOLATION AND CHARACTERIZATION OF THE CHEMICAL CONSTITUENTS OF STELLARIA MEDIA LINN.
The studies on the constituents of aerial parts of Stellaria media Linn. (Caryophyllaceae) have led to the isolation and characterization of three new compounds ─ (1), (2) and (3). Structure elucidation of the new compounds was carried out using 1H NMR, 13C NMR, Mass spectrometry together with other complementary techniques (UV and IR). The major findings of the study include: Compound 1 was sep...
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PROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF AEGLE MARMELOS FRUIT IN CYCLOPHOSPHAMIDE INDUCED TOXICITY IN RATS
Aegle marmelos commonly known as Bael has been widely used traditionally due to its various medicinal properties. Cyclophosphamide is an alkylating agent used in the treatment of various types of cancer by slowing or stopping the growth of cancer cells but also affecting the normal cells leading to immunosuppressant effect. The present study has been aimed to see the protective effect of hydroalco...
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QUALITY OF LIFE OF POSTMENOPAUSAL WOMEN RECEIVING PLANT-BASED PHYTOESTROGENS
Background: A gradual and continuous loss of oestrogen may place the middle age woman at the risk of getting menopause symptoms, which profoundly affects her comfort. A phytoestrogen is a natural plant hormone similar to the female hormone oestrogen. Eating dietary phytoestrogen, improve the health standard of women by producing and regulating oestrogen level in the body. Materials and Methods: A ...
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PROSTATE CANCER: RISK FACTORS, SCREENING, DIAGNOSIS AND TREATMENT
Prostate cancer is one of the most important cancer in men. In most cases, prostate cancer confirmed by histological and transrectal biopsy for the examination of prostatic tissue. Metastatic prostate cancer is second leading cause of death from cancer. Androgen deprivation therapy is common treatment in men with prostate cancer that may cause fatigue, increased body fatness, and loss of lean body...
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NANOEMULSION: A SNAPSHOT ON DEVELOPMENT, CHARACTERIZATION, APPLICATIONS, PATENTS AND CLINICAL TRIALS
Nanoemulsionis a special case of emulsion. It is nano-sized emulsion used as a carrier. It has the ability to deliver the drug to the target site. It is a good vehicle for the controlled delivery of the drug. It is prepared by the high energy and low energy emulsification method. Emulsifier plays an important role in stabilizing the nanoemulsion. It is anisotropic and thermo-dynamically stable sys...
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