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COMPARISON OF PHYSICOCHEMICAL, THERMAL, PASTING AND MORPHOLOGICAL PROPERTIES OF WEED RICE AND RICE STARCHES
A novel starch was isolated from weed rice crop and its starch properties were compared with rice starch. The starch properties studied were physicochemical, pasting, thermal and X-ray diffraction. The amylose content and swelling power (g/g) of weed rice starch was 13.7% and 19.8 g/g, respectively. Light transmittance (%) of starch paste from weed rice was observed higher as compared to rice star...
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DEVELOPMENT AND VALIDATION OF GC-MS METHOD FOR THE TRACE LEVEL DETERMINATION OF STRUCTURALLY ALERT ALKYL HALIDE IMPURITIES IN CILASTATIN SODIUM DRUG SUBSTANCE
A Simple and trace level-sensitive Gas chromatography with mass spectrometer (GCMS) method was developed, optimized and validated for the determination of seven potentially genotoxic impurities which are having structural alerts i.e., 1-Bromo-5-chloropentane (PGI-1), Ethyl-6-chloro-2-oxo hexanoate (PGI-2), Methyl-7-chloro-2-oxo hepta-noate (PGI-3), Ethyl-7-chloro-2-oxo heptanoate (PGI-4), Ethyl-7-...
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SYNTHESIS AND MOLECULAR DOCKING STUDY OF BIOACTIVE QUINOLINO- BENZIMIDAZOLE DERIVATIVES
A series of some quinolino-benzimidazole/thiazole derivatives (3a-3h) have been synthesized from2-hydroxyquinoline-3-formaldehyde derivatives (1a-1d) and 1, 2-phenylenediamines/2-aminothiophenols (2a-2c). The synthesized compounds were characterized by FTIR, 1H-NMR and Mass Spectrometry. All the compounds were screened in-vitro for their antibacterial activity against Mycobacterium tuberculosis (H...
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IN-VIVO ROENTGENOGRAPHIC EVALUATION OF COLON TARGETED 5-FLUOROURACIL PELLETS
Objective: This study was an attempt to explore the latent of colon specificity approach utilizing pH-sensitive and time-dependent characteristics of polymers for defined colonic release of 5-Fluorouracil (5-FU). Method: The pellets were prepared by extrusion-spheronization method which is an industry-accepted method due to its ease of formulation. The prepared pellets were the matrix of 5-Fluorou...
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THE HEPATIC CYP3A4 UPREGULATED INCREASED METABOLISM IN RESPONSE TO PHYSICAL ACTIVITY AT HIGH ALTITUDE
The present study was designed to assess the pharmacokinetics of drug metabolized by hepatic cytochrome 3A4 (CYP3A4) in human volunteers with physical activity at the high altitude hypobaric hypoxic environment. The International Physical Activity Questionnaire short form 7 (IPAQ SF-7) was used to measure the physical activity. The total of 24 healthy male volunteers participated in this study; fo...
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SIMULTANEOUS ESTIMATION OF TEA TREE OIL AND NEEM SEED OIL IN BULK AND COSMECEUTICAL FORMULATION BY UV SPECTROPHOTOMETRY
Tea tree oil, an essential oil, has claims for analgesic, antimicrobial, antiseptic, and anti-inflammatory activity. Its complex composition is governed by ISO 4730:2017. It is extensively used in skin and hair care cosmeceuticals, often in combination with neem seed oil. Neem seed oil has potent antimicrobial, skin rejuvenating, and conditioning action attributed to the presence of micro constitu...
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ETHNOBOTANICAL, PHYTOCHEMICAL AND PHARMACOLOGICAL SCIENCE OF TRACHYSPERMUM AMMI (AJWAIN) A SYSTEMATIC REVIEW
The aim of the present investigation was a systemic review of Trachyspermum ammi L. (Ajwain) coming from the family Apiaceae and its medicinal significance. The seeds of ajwain include approximate three-5% crucial brownish oil, and this species additionally incorporate thymol as the principal chemical constituent at the side of a few different important constituents like β-pinene, α-terpinene, Î...
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CHEMICAL CONSTITUENTS OF ANDROGRAPHIS PANICULATA (BURM.F) NEES: A REVIEW
Andrographis paniculata Nees is a valuable medicinal herb of Acanthaceae family, is used for centuries to treat several diseases including viral hepatitis, cirrhosis, malaria and diabetes. This medicinal plant has hepato-protective, immunological, anti-bacterial, anti-inflammatory, anti-oxidant and antithrombotic qualities. It has many important bioactive compounds such as diterpenoids, flavonoids...
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EVALUATION OF PHYTOCONSTITUENTS, FT-IR ANALYSIS, TOTAL PHENOLIC, FLAVONOID CONTENTS, IN-VITRO ANTIBACTERIAL AND ANTIOXIDANT STUDIES OF ETHANOLIC ROOT EXTRACT OF MILLETTIA PINNATA
This research work presents the phytochemical and FTIR analysis, total phenolic, and flavonoid quantification, and evaluation of in-vitro antibacterial and antioxidant activity of ethanolic root extract of Millettia pinnata. Ethanolic root extract was subjected to the phytochemical and FTIR spectrum analysis. Total phenolic and flavonoid contents were quantitatively determined by Colorimeter. The ...
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IN-VITRO AND IN-VIVO QUANTITATIVE ESTIMATION OF TOTAL PHENOLS, ASCORBIC ACID CONTENT AND ANTIOXIDANT ACTIVITY IN NORMAL FLOWER AND FLOWER GALL OF CRATAEVA RELIGIOSA
Plant galls are remarkable close associations between plants and insects, in which the plant produces an abnormal growth of tissue in response to a specific stimulus from the attacking insect. The present investigation was undertaken to assess the antioxidant activity as well as the total phenols and ascorbic acid content in in-vivo (normal flower and galled flower) and in-vitro (unorganized stati...
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