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IN-VITRO TRANSPORT EVALUATION OF GARCINIA MANGOSTANA L. PERICARP EXTRACT LOADED CREAM AND GEL
Garcinia mangostana L. pericarp (GMP) has been known as a traditional medicine in Asian countries. The bioactive from GMP has been recognized to be related to complex phenolic compounds linked with free radical scavenging activity. This research aimed to study the effects of topical formulation types (gel, oil in water cream and water in oil cream) of GMP extract on the in-vitro release and in-vit...
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STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR DETERMINATION OF RELATED SUBSTANCE IN VENLAFAXINE HYDROCHLORIDE TABLETS
Recently, several methods have been developed for the determination of drugs and their impurities products by Reverse Phase-High Performance Liquid chromatography (RP-HPLC). The present paper describes highly specific, linear, precise, rugged, accurate, robust, and stability, indicating the RP-HPLC method for the determination of related substances present in Venlafaxine tablets as per ICH guideli...
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SPECTROPHOTOMETRIC ANALYSIS OF BOVINE SERUM ALBUMIN IN PRESENCE OF 1-(4-AMINOPHENYL)-3-PHENYLPROP-2-EN-1-ONES
Proteins, which are soluble under normal physiological conditions, sometimes form insoluble aggregates with serious medical implications. Bovine serum albumin (BSA), a structural analogue of human serum albumin. Bovine Serum Albumin (BSA) has been used as a carrier, and stabilizing agent, for insoluble fatty acids. The chemistry of chalcone has been recognized as a significant field of study. An i...
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RECOVERY OF DIMINISHED SPERMATOGENESIS BY RESVERATROL AGAINST THE PYRETHROID, LAMBDA CYHALOTHRIN-INDUCED REPRO-TOXICITY IN ALBINO RATS
Lambda-cyhalothrin [-cyano-3-phenoxybenzyl 3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate] is one of the type II synthetic broad-spectrum pyrethroids used to protect the crops against insects. The aim of the present study was to evaluate the protective effect of resveratrol on male reproductive health in lambda-cyhalothrin exposed rats. Exposure of male rats to lambda-...
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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR QUANTITATIVE DETERMINATION AND ESTIMATION OF ASENAPINE MALEATE IN BULK AND BUCCAL (EFFERVESCENT) DOSAGE FORM
Asenapine maleate is an atypical antipsychotic drug. It was approved by USFDA in August 2009. It is an antagonist of 5-HT dopamine and α-adrenergic receptors and a high affinity for dopamine D2 and serotonin 5-HT2A receptors. It is indicated for the treatment of various psychotic conditions like schizophrenia and bipolar disorder in adults. So it leads to the requirement of accurate and precise...
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AN UPDATE ON BIOLEACHING TECHNOLOGY: IRON BACTERIA AS A SOURCE OF OXIDIZING IRON TRACES FROM WATER SAMPLES
The removal of metals by the use of microbes is known as bioleaching in terms of oxidation or degradation of metal from complex raw materials or depots. Such microbial oxidation or bio-removal occurs in terms of sulphur degradation and oxidation (for example, sulphur oxidation, iron oxidation etc.). This process is thus known as bioleaching, which is related to the all metal oxidation processes li...
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NANOSPONGES AS NOVEL CARRIER FOR TOPICAL DELIVERY OF LULICONAZOLE -AN ANTIFUNGAL DRUG
The main goal of this work is to formulate nanosponges and access its suitability to deliver Luliconazole for topical application, to improve its therapeutic effect, better dispersion and good storage. Nanosponges are water-soluble, which does not mean that molecules are chemically decomposed in water but that nanosponge particles are mixed with water and used as a carrier fluid. Compared with tra...
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THE EVALUATION OF VITAMIN C SUPPLEMENTATION ON NUTRITIONAL STATUS OF PATIENTS WITH ACUTE MYELOID LEUKEMIA UNDERGOING CHEMOTHERAPY
Background: Leukemia is the seventh common cancer in Iran, and AML is considered as the most common type. Malnutrition is common among patients with cancer. Vitamin C deficiency has a high prevalence among patients with cancer, which may influence a patient's survival chance. This study was aimed to evaluate the effect of vitamin C supplementation on nutritional status and serum albumin in patient...
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C-TERMINAL CLAW STABILISATION IN CORVUS AVIAN BETA DEFENSIN 7 AND ITS MUTATION STUDIES
Antimicrobial peptides are considered as promising and potential next-generation antibiotics on account of their broad spectrum of antimicrobial activity and unique mode of microbial killing. For therapeutic application, it is essential to consider the hemolytic or cytotoxic property of AMPs along with antimicrobial function. In the current study, an avian beta-defensin 7 (AvBD7) gene was identifi...
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A STUDY TO EVALUATE THE TOTAL ORGANIC ACID CONTENT IN URINE OF CALCIUM OXALATE RENAL STONE FORMERS AND NON STONE FORMERS
Renal stones disease is the most common disease of the urinary tract affecting about 10% of the global population. Renal stone disease is a common disorder that develops when the urine becomes overly saturated with certain microscopic substances that bind into hardened mineral deposits known as renal stones. The objective of our current study is to evaluate the total organic acids of urine of calc...
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