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ANALYSIS OF BIOACTIVE COMPOUNDS PRESENT IN METHANOLIC EXTRACT OF PHYMATOSORUS SCOLOPENDRIA (BURM. F.) PIC. SERM. THROUGH GAS CHROMATOGRAPHY AND MASS SPECTROSCOPY
Phymatosorus scolopendria (Burm. F.) Pic. Serm. belongs to the family Polypodiaceae which is commonly known as musk-fern or wart-fern. Medicinally, the experimental plant possesses insect repellent, anti-inflammatory and bronchodilator activity and hence used ethnomedicinally by tribal people, but was not explored for its bioactive compounds. Hence, the objective of this study was to determine the...
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PHYTOCHEMICAL SCREENING, ANTIOXIDANT AND CARBOHYDRATE DIGESTING ENZYME INHIBITORY POTENTIAL OF LEUCAENA LEUCOCEPHALA LEAVES EXTRACT
The study aims to investigate the antioxidant and antidiabetic activity of Leucaena leucocephala ethanol leaf extract (LLME). L. leucocephala leaves extraction was carried out by the maceration method. Phytochemical analysis was performed using standard analytical procedures. Diphenyl picrylhydrazyl (DPPH) radical and 2, 2’-azinobis (3-ethylbenzathiazoline-6-sulfonic acid) (ABTS) radical scaveng...
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HISTOPATHOLOGICAL ALTERATIONS IN ALLOXAN INDUCED DIABETIC MICE LIVER AND KIDNEY AFTER CARISSA SPINARUM METHANOLIC LEAF EXTRACT TREATMENT
Carissa spinarum is an evergreen, thorny shrub found in the Himalayan areas of the Indo-Pakistan subcontinent. The plant has a number of ethnomedicinal applications. Pharmacologically this plant is used for the treatment of asthma and pulmonary diseases, anticancer, diarrhea, hepatoprotective, cardioprotective and reproductive dysfunction. The present study is aimed to study effects of Carissa spi...
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NEUROLOGICAL, HAEMATOLOGICAL AND HISTOLOGICAL EFFECTS OF CHRONIC EXPOSURE TO NITROUS OXIDE IN WISTAR ALBINO RATS
Objectives: The objectives of the study were to investigate the neurological, hematological, and histological effects of chronic exposure to nitrous oxide (N2O) in male Wistar albino rats. Methodology: 12 adults, male, Wistar albino rats (150-200g) were divided into 2 groups of 6 animals each. Group 1 served as control. Group 2 received N2O + O2 (70:30 mixture) for 1 h every day for 60 days. Neuro...
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SYNTHESIS, CHARACTERIZATION, BIOLOGICAL AND FLUORESCENT BEHAVIOUR OF METAL (II) COMPLEXES WITH PYRAZOLINE DERIVATIVES
Novel metal complexes of ligands of pyrazoline derivatives were synthesized by the condensation of 1-acetyl-2-hydroxynapthalene and indole-3-carboxaldehyde followed by the condensation of substituted phenylhydrazine. They were characterized by elemental analysis, IR, 1H-NMR, UV-Vis., molar conductance, magnetic susceptibility measurements and electrochemical studies. Based on the magnetic moment a...
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THE RELATIONSHIP BETWEEN CLINICAL FEATURES AND MAGNETIC RESONANCE IMAGING PROVED LUMBAR DISC BULGING AND HERNIATION
Background: Lumbar disc herniation is one of the commonest causes of low back pain. The magnetic resonance imaging is a gold standard non-invasive investigation for viewing lumbar anatomy in detail. Aim of the Study: To evaluate the effects of body mass index on the presence, extent and severity of lumbar disc bulging and herniation as well as to determine the relationship between clinical feature...
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DESIGN, SYNTHESIS AND COMPARATIVE PHARMACOLOGICAL ASSESSMENT OF NOVEL FLUOROQUINOLONE DERIVATIVES
One of the proposed groupings of the fluoroquinolones describes the excellent broad-spectrum activity forms an invaluable part of the present anti-infective armory of the clinicians. The fluoroquinolones are most significant weapons can be credited for saving more human lives than any other area of medicinal therapy. In this current research segment, the novel C-3 substituted fluoroquinolone scaff...
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DEVELOPMENT AND VALIDATION OF UPLC METHOD FOR ESTIMATION OF % RELEASE OF SOME ANTI-HIV DRUGS IN FIXED DOSE COMBINATION
A simple, accurate and precise UPLC method was developed and validated for dissolution testing of Lamivudine, Tenofovir disoproxil fumarate and Efavirenz in tablet dosage form. The separation was achieved under optimized chromatographic condition on an Acquity UPLC BEH (50 mm × 2.1 mm, 1.7 μm) column with mobile phase consist of 20 mM potassium dihydrogen phosphate buffer pH 2.5: acetonitrile wi...
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DEVELOPMENT OF OSMOTIC CONTROLLED RELEASE FORMULATION OF AN ANTIDIABETIC DRUG METFORMIN HYDROCHLORIDE
Osmotic tablets have emerged as a new technology for the delivery of drugs whose release rate is to be controlled. These tablets offer controlled drug release with the help of certain osmogens and also provide zero-order rate kinetics. In the present study, we have developed an osmotic tablet of Metformin Hydrochloride (HCL) to enhance its oral bioavailability. Metformin HCL is a biguanide derivat...
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FORMULATION AND EVALUATION OF SOLID LIPID NANOPARTICLE GEL FOR TOPICAL DELIVERY OF CLOBETASOL PROPIONATE TO ENHANCE ITS PERMEATION USING SILK SERICINAS PERMEATION ENHANCER
The objective of this present work was to develop Solid Lipid Nanoparticle (SLN) gel for topical delivery of clobetasol propionate to enhance its permeation using silk sericin as a permeation enhancer. The proposed Clobetasol propionate gel loaded with solid lipid nanoparticle was prepared by solvent injection method. The effects of different strengths of lipid on the particle size, zeta potential...
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