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A REPRODUCTIVE AND DEVELOPMENTAL STUDY FOLLOWING 28 DAYS REPEATED ORAL EXPOSURE OF LEAVES OF PTEROSPERMUM ACERIFOLIUM (L.) WILLD IN WISTAR ALBINO RATS
The present study was aimed to evaluate the effects of repeated administration of methanolic leaf extract of Pterospermum acerifolium Linn. Willd. (MEPA) on the reproductive system of male and female Wistar albino rats and its developmental effects on subsequent generation. MEPA was administered to Wistar albino rats by gavage for 28 days repeatedly at doses of 250, 500 and 1000 mg/kg body weight,...
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HPTLC METHOD DEVELOPMENT AND VALIDATION FOR IDENTIFICATION AND QUANTIFICATION OF LUPEOL IN THE LEAVES OF ALSTONIA SCHOLARIS
In ancient literature plant Alstonia scholaris (Apocynaceae) has been considered medicinally important in the treatment of various ailments. Extracts of this plant have shown wide spectra of pharmacological activities like anti-cancer, hepatoprotective, anti-inflammatory, anti-diabetic, etc. These activities can be attributed to the depositories of various phytoconstituents like alkaloids, flavono...
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DESIGN AND SYNTHESIS OF NOVEL HYDRAZONES OF ETHYL3-AMINO-4-HYDROXYBENZOATE AS PROMISING ANTICONVULSANT AGENTS
A series of hydrazide-hydrazones (3a-o) have been synthesized by the reaction of acid hydrazide (2) which is obtained from 4-carbomethoxy-2-aminophenol with aromatic acid through multi-steps. The bioactivities of the final compounds were tested with MES and scPTZ methods. The CNS toxicity was studied by the rotarod experiment. Based on the results, compounds 3d and 3o were found to be most active ...
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SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL QUINOLINE / CHALCONE HYBRID AS POTENTIAL ANTIBACTERIAL AGENTS
A series of new quinoline/chalcone hybrids 3a-e and 4a-e were designed and synthesized. The structures of all new target molecules 3a-e and 4a-e have been confirmed by various spectral techniques and elemental analyses. The newly synthesized compounds were screened for their antibacterial activity using agar disc diffusion method. Results showed that most of the newly synthesized compounds showed ...
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AN INVESTIGATION FOR PRESCRIPTION DRUGS IN AN ARENA OF VIRAL DISEASES
WHO’s global health expenditure data base explores internationally comparable data on health spending in all WHO Member States. The report incorporates data analytics for various diseases, health expenditure and death toll etc., globally. Viral diseases have always been a burning issue for morbidity and mortality, worldwide. Viral diseases such as Chickenpox, Malaria, Cholera, Bronchitis, Tuberc...
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FABRICATION AND CHARACTERIZATION OF NANOSUSPENSION FORMULATION OF DIOSMIN FOR ENHANCED ORAL DELIVERY
Nanosuspension is a biphasic system consisting of drug particles dispersed in an aqueous surfactant or polymeric solution with a particle size between 10 to 1000 nm. Nanosuspension offers the unique advantage of increasing solubility of the pure drug resulting into faster drug absorption and hence achieving faster maximum plasma concentration. Hence, the aim of this research work was to formulate ...
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RISK OF DEVELOPING DEPRESSION AND ITS IMPACT ON QUALITY OF LIFE IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME – A SOUTH INDIAN SCENARIO
Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine disorders, affecting the patient’s psychological functioning and satisfaction with life. Settings and Design: Tertiary care hospital based case-control study was conducted. Material and Methods: the study was effectuated in 372 patients in total, including an equal number of cases and controls.PHQ-9 was used to det...
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EVALUATION OF EFFECT OF AYURVEDIC PREPARATIONS ON NEPHROPATHY IN DIABETIC WISTAR RATS
Introduction: Type 2 diabetes, which is the most common type, is often a result of excess body weight and physical inactivity in genetically predisposed individuals. Over due course of time diabetes can cause blindness, kidney damage, neurological problems, and coronary artery disease. Improvement in glycemic control is important factors in delaying the onset and progression of diabetes-related co...
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EVALUATION OF CORRELATION FACTORS FOR PREVALENCE OF ANEMIA AND UTILIZATION OF HEMATINICS AMONG PREGNANT AND LACTATING WOMEN
Anemia is defined as a decreased hemoglobin level or circulating red blood cells, and it is the most common hematological disorder during pregnancy. The study was aimed to review the prevalence of anemia in pregnant and lactating women and to find out the correlation between educational status and prevalence of anemia if any. A Concurrent Observational study was carried out Using a Case Sheet of t...
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A RANDOMIZED SINGLE BLIND PLACEBO CONTROLLED CLINICAL STUDY TO EVALUATE EFFICACY OF AMALAKI (EMBLICA OFFICINALIS) EXTRACT CAPSULE ON ACNE VULGARIS ALONG WITH ITS ANTI-OXIDANT PROPERTY
Background and Objectives: Acne vulgaris is a chronic skin infection affecting the majority of teenagers and adolescents. It is a disease that affects almost 80% of individuals. Acne, by definition, is multi-factorial chronic inflammatory disease of the Pilosebaceous unit. Nowadays, herbal formulations are gaining popularity in the treatment of various diseases. By considering this fact, the prese...
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