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EVALUATION OF BINDING AFFINITY OF THE SELECTED HERBAL BIO-ACTIVE COMPONENTS WITH THE ENZYME CYP- 17Α-HYDROXYLASE BY PCOS AMELIORATION ACTIVITY THROUGH MOLECULAR DOCKING IN- SILICO APPROACH
Polycystic ovarian syndrome (PCOS) known by its name can be correlated with Soothaga Vaayu in Siddha classical literature which is one of the most common forms of metabolic and endocrine disorders of women, with a high prevalence among the reproductive age group, often associated with obesity, hypertension, insulin resistance, diabetes mellitus, hyperinsulinemia and dyslipidemia. Current therapeut...
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EVALUATION OF HAIR GROWTH PROMOTING ACTIVITY OF ACALYPHA INDICA ETHANOLIC EXTRACT WHOLE PLANT
Traditionally, alopecia, a major illness throughout the world, has been treated with medicinal plants and their oils. Hair treatments, including those that stimulate hair growth, cost about $10 billion a year. A big worry is hair loss, which is mostly brought on by junk food and erratic lifestyle choices. The function of the ethanolic extract of the entire A. indica plant is examined in this study...
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COMPARATIVE STUDY OF THE EFFECTS OF LAURUS NOBILIS AND SYZYGIUM AROMATICUM AQUEOUS EXTRACTS ON URINE VOLUME AND RENAL FUNCTION IN RATS
The purpose of the current study was to investigate the diuretic and renal effect of the aqueous extracts of Laurus nobilis leaves and dried flower buds of Syzygium aromaticum. Four groups of rats were used. Group 1 received distilled water (10 ml/kg BW), group 2 received the aqueous extract of Laurus nobilis (300 mg/kg BW), group 3 received the aqueous extract of Syzygium aromaticum (300 mg/kg BW...
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DESIGN, SYNTHESIS, CHARACTERIZATION AND EVALUATION OF NEWER POTENT APOLIPOPROTEIN E4 INHIBITORS FOR THE TREATMENT OF ALZHEIMER’S DISEASE
A major genetic suspect for Alzheimer's disease is the pathological conformation assumed by Apolipoprotein E4(Apo E4) through intramolecular interaction. The aim of the current study is to synthesize newer potent Apo E4 inhibitors. In the present study, with specific pharmacophoric features of three Hydrogen bond donors and three hydrophobic spheres, a large library of ligands was constructed for ...
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NEGLIGIBLE EFFECT OF SOME COUNTERFEIT ANTI-OBESITY DRUGS
Objective: To evaluate the effect of some counterfeit anti-obesity drugs that are not licensed by the Ministry of Health. Materials and Methods: 100 male rats were divided into 10 groups. The first group received a normal diet for two months. The second group received a high-fat diet (HFD) for two months; the third group received HFD for one month then returned to a normal diet. The remaining seve...
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UTILITY AND EFFECTIVENESS OF GENEXPERT OVER CONVENTIONAL METHODS FOR DIAGNOSIS OF PULMONARY TUBERCULOSIS
Background: Tuberculosis (TB) is a global health burden and can cause potential infection in any system of the body. Pulmonary tuberculosis (PTB) is most common presentation, but the diagnosis of TB remains elusive because of none of biochemical or serological test is invalid. During the development of END TB strategy, the gene expert (CBNAAT) test was first endorsed by WHO. Materials and Methods:...
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PHARMACOKINETIC EVALUATION OF GENTISIC ACID IN RATS: ORAL VERSUS INTRAVENOUS ADMINISTRATION
Gentisic acid (2, 5-dihydroxybenzoic acid) is a diphenolic compound, present abundantly in natural sources. It possesses several pharmacological activities such as nephroprotective, hepatoprotective, neuroprotective, etc. However, the available literature on oral absorption of gentisic acid is scarce. Thus, the aim of the present study was to determine the pharmacokinetic parameters and bioavailab...
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TRANSDERMAL DRUG DELIVERY SYSTEM: AN ATTRACTIVE APPROACH FOR TREATMENT OF NEUROLOGICAL DISORDERS
Neurodegenerative diseases are progressive degeneration of certain nerve cells causing ataxias and dementia affecting millions of people worldwide. Transdermal drug delivery systems – “patches” represent an attractive alternative to the conventional method and have made an important contribution to the management of the various medical conditions. A transdermal patch is a medicated adhesive ...
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A GEL CASTING TOOL FOR FABRICATION OF THREE DIMENSIONAL SANDWICH IN-VITRO CULTURE SYSTEM FOR CYTOCOMPATIBILITY EVALUATION OF HYDROGELS
Two-dimensional (2D) culture systems are indispensably used as in-vitro tools to improve our perception and understanding of cell biology, tissue engineering, tissue morphology, mechanisms of diseases, and drug action. However, the conventional 2D culture systems suffer from limitations such as alterations in cell morphology and lack of interactions between extracellular and cellular environments....
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PRIMER DESIGNING AND STANDARDIZATION OF PRIMER ANNEALING TEMPERATURE FOR BETA-3-ADRENERGIC RECEPTOR IN MUS MUSCULUS
Adrenergic receptors (ADRs) are implemented in important pharmacological responses. The β3adrenergic receptors have been proposed as a suitable drug target for treating diabetes and obesity. However, very little information is available regarding the expression profile of β3 receptors. We have designed primers for studying the β3adrenergic receptors in C57BL/6J mice using various bioinformati...
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