Streblus asper Lour is traditionally used for anti-diarrheal and anthelmintic activity. The present study aims to prove the antidepressant activity in a different extract of leaves of S. asper Lin animal models. The extracts of Sterblus asper L. significantly reduced the immobility time in the forced swimming test (FST), notable at 400 mg/kg when compared with the control group. The immobility tim...
FORMULATION, OPTIMIZATION AND CHARACTERIZATION OF TOPICAL FILM-FORMING SOLUTION FOR TREATMENT OF DIABETIC FOOT ULCER
Diabetic foot ulcer is one of the leading causes of lower limb amputation and mortality in diabetic patients. Various factors contribute to the manifestation of chronic wounds in diabetic foot, but ischemia, infection, and elevated levels of matrix metalloproteases enzyme are the main factors. Matrix metalloproteases (MMPs) are elevated to as high as 60%. Thus, altering the wound-healing process. ...
CELECOXIB, A SELECTIVE CYCLOOXYGENASE-2 INHIBITOR, IS ANTICONVULSIVE IN MES INDUCED SEIZURES BUT PROCONVULSIVE IN PTZ INDUCED SEIZURES IN MICE: A POSSIBLE ROLE OF EXCITATORY AMINO ACID IN THIS DIFFERENTIAL EFFECT
Epilepsy is an achronic neurological disorder characterized by recurrent seizures. There is a positive feedback cycle between epileptogenesis and brain inflammation. It has been proved that COX 2 is expressed constitutively in certain parts of the CNS and is further induced as a result of seizurogenic activity. Of the various experimental models of epilepsy, one is the maximal electroshock (MES) m...
IN-VIVO ANTI-CANCER AND HISTOPATHOLOGY STUDIES OF MORINGA OLEIFERA ON EHRLICH ASCITIC CARCINOMA CELLS
Moringa oleifera is an important food commodity with enormous attention as the 'natural nutrition of the tropics. Leaves of this plant are traditionally known for or reported to have various biological activities, including hypocholesterolemic agent, antidiabetic, gastric ulcers, antitumor and hypotensive agent. This study was designed to assess the toxicological and histopathological effects of e...