Posted by admin on Jan 31, 2026 in |
The increasing prevalence of drug-resistant pathogens underscores the need for alternative antimicrobial agents, particularly plant-derived phytochemicals. This study evaluated the antimicrobial potential of Soleirolia soleirolii, Arctium lappa (Burdock), and Psidium guajava using two extraction methods: decoction and percolation. Extraction yields varied, with decoction producing 25.0% (A. lappa) to 44.8% (P. guajava) and percolation yielding 33.2% to 49.7%, indicating improved recovery of thermolabile compounds in percolation. Antimicrobial activity was assessed in-vitro against Gram-positive (Bacillus cereus, Staphylococcus aureus), Gram-negative (Salmonella, Escherichia coli, Pseudomonas aeruginosa), and fungal (Candida albicans, Clostridia) strains. A. lappa showed broad-spectrum activity across both methods (zones: 8.5–11.0 mm), while P. guajava exhibited selective antibacterial effects, particularly against S. aureus and Salmonella, and strong antifungal activity against Clostridia. S. soleirolii displayed moderate, selective inhibition, with percolation enhancing activity against Salmonella. These findings highlight that extraction technique significantly influences yield and bioactivity. Overall, A. lappa is a promising natural antimicrobial, whereas P. guajava and S. soleirolii merit further bioassay-guided fractionation to identify active phytoconstituents for potential therapeutic applications against resistant...
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Posted by admin on Jan 31, 2026 in |
India is endowed with several tribal foods. Tribal foods have received global recognition for their potential to improve food security while enhancing biodiversity worldwide. The valuable properties of wild tribal foods require proper study and documentation in order to bridge the gap between scientific evidence generation and ancestral indigenous people’s knowledge. Herbal recipes were prepared by the Bodo tribe from immemorial time during the Rongajali Bwisagu Festival from April to the end of April in the Bodoland Territorial Region of Assam. In this festival, people collect a total of 101 plant species. Usually, these 101 plant species are used to prepare an herbal food recipe. These plant species have been used for thousands of years for health benefits in this region. People believe these ingredients can strengthen plant species and destroy many viruses. This recipe preparation is a rich source of phytochemicals that help protect humans’ wellness. This herbal recipe can help treat many diseases like- anti-hypertensive potential, anti-cancer, anti-diabetes, anti-bacterial, skin diseases, fever, ulcers, ringworms, allergic asthma, wound...
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Posted by admin on Jan 31, 2026 in |
Background: Chronic pharyngitis, often associated to Gastroesophageal reflux disease (GERD) and Laryngopharyngeal reflux disease (LPRD), presents significant therapeutic challenges. Objective: To compare the clinical efficacy of 2% w/v Povidone-Iodine (PI) and 0.15% w/v Benzydamine Hydrochloride (BZ) gargles in patients with chronic pharyngitis secondary to LPRD/GERD. Methods: This prospective, randomized, open-label study compared the efficacy of PI and BZ topical gargles, combined with Omeprazole (20 mg) and Cinitapride (3 mg) once daily orally. Clinical outcomes were evaluated using the Reflux Symptom Index (RSI) and Visual Analogue Scale (VAS) at baseline, day 15, and day 30. Results: Both groups exhibited significant improvement (p<0.05) in RSI and VAS scores over 30 days. BZ group showed effective pain reduction (VAS: 0.48±0.58 vs. 0.62±0.70; *p=0.014) and higher rates of complete pain resolution (56% vs. 50%) compared to PI group. PI achieved 100% resolution in reflux-associated symptoms (heartburn, postprandial cough), while BZ mainly improved neurogenic symptoms (globus sensation: 96.9% vs. 90%; hoarseness of voice: 92% vs. 78.3%). However, composite RSI reduction was comparable (BZ: 85.6%...
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Posted by admin on Jan 31, 2026 in |
Chemotherapy remains a cornerstone of cancer management but is often accompanied by significant toxicity and economic burden. Drug Utilization Studies (DUS) are essential for evaluating prescribing practices and ensuring rational, cost-effective therapy. This retrospective cross-sectional study analyzed the drug utilization patterns of 400 oncology patients at Goa Medical College between February and March 2024. Data was assessed using WHO prescribing indicators and descriptive statistics. Of the patients, 70% were female, and breast cancer being the most common diagnosis (49.5%). Paclitaxel (38%), trastuzumab (35%), and cyclophosphamide (28%) were the most frequently prescribed chemotherapeutic agents. The supportive drugs included palonosetron (82%), dexamethasone (70%), and ranitidine (63%). Advanced agents such as Zoledronic Acid and Leuprolide were used for bone metastases and hormone-sensitive cancers. High-cost biologics, such as Bevacizumab and Rituximab, were provided under the MJPJAY scheme, ensuring universal access. Injectable formulations accounted for 87% of prescriptions, 97.3% of which were prescribed by generic name, and 100% were listed in the WHO Essential Medicines List. Antibiotic use was low (3%), indicating strong antimicrobial...
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Posted by admin on Jan 31, 2026 in |
A Quality by Design approach to analytical method development involves selection of predetermined objective, determined critical parameters, evaluation, appropriate method selection and risk assessment. Analytical Quality by Design (AQbD) helps to understand the selected method more precisely than traditional method. An important component of AQbD is understanding of independent variables (Factors) and dependent Variables (Response) and their interactions were analysed. Present study entails AQbD driven development of reversed-phase (RP) high-performance liquid chromatography (HPLC) for simultaneous estimation of Furazolidone and Metronidazole in pharmaceutical dosage form. The risk based HPLC method development and validation for combination of pharmaceutical dosage form helps to optimize the separation process of the APIs. The chromatographic conditions were optimized using Stat-Ease 360 software ,with 32 factorial design applied to analyse the effect of mobile phase composition and flow rate and effect was evaluated on retention time, number of theoretical plates (NTP), symmetry factor and resolution. The analysis was performed on HiQSil C18H5 column (4.6mm ×250mm) using acetonitrile: phosphate buffer (pH adjusted to 3 with 0.1% OPA)...
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