Posted by admin on Oct 1, 2014 in |
In this research study, the effect of drug release of albendazole chewable tablets has been determined. The drug release is calculated by using the disintegration process, which is directly related to the hardness of tablets. The tablets are prepared by using three types of granulating methods are non-aqueous granulation, aqueous granulation, and direct compression. The tablets are evaluated by calculating different parameters such as hardness, friability, disintegration, assay, and in-vitro dissolution studies. The % drug release was determined by using U V spectrophotometry. In the three techniques and the non-aqueous granulation was the better technique for the formulation of tablets, dissolution rate, and % drug release other than aqueous granulation and direct compression method. So by this, we can say the non- aqueous technique gives immediate drug release by which the drug can be used at the time of emergency and gives relief to the patient, and the chewable tablets can use for the children easily. The present study was to prepare the chewable albendazole tablets by granulating techniques,...
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Posted by admin on Oct 1, 2014 in |
Purpose: The focus of the present paper was a preliminary phytochemical and TLC analysis of the various extracts (root, stem, and leaf) of the mangrove plant Excoecaria agallocha L. Methods: Phytochemical analysis was carried out using the standard phytochemical assays. TLC analysis of the petroleum ether and chloroform fraction of the leaves was carried out using the solvent system Toluene: Ethyl acetate (in 9:1 ratio) and Toluene: Ethyl acetate: Formic acid (in 5:5:0.2 ratio) for PE and chloroform fractions respectively. Result and Conclusion: The results of the preliminary phytochemical screening revealed the presence of various chemical compounds like alkaloids, glycosides, flavonoids, carbohydrates, anthraquinone, tannins, phenols, terpenoids, fixed oil, and fats. The organoleptic study revealed the specific nature of the plant parts used in the study. The behavior of the powdered plant parts in the presence of various chemicals was studied. TLC analysis of the petroleum ether and chloroform fraction of the leaves of Excoecaria agallocha L. revealed bands indicating the presence of various compounds that could act as potential...
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Posted by admin on Oct 1, 2014 in |
Objective: To formulate economic transdermal patch of lornoxicam (LX) and to study its anti-inflammatory activity on acute and chronic inflammatory in rat models. Method: Three LX transdermal patches (F1, F2, and F3) consist of Eudragit RL-100, and RS-100 in three different ratios (1:2, 1:1 and 2:1) were prepared respectively by the solvent evaporation technique. All formulations contain diethyl phthalate as a plasticizer. The physicochemical compatibility of the drug and the polymers was studied by differential scanning calorimetry. The prepared LX transdermal patches were evaluated for their drug content, patch thickness, folding endurance, surface pH, and in vitro drug permeation. The anti-inflammatory activity of LX transdermal patch was determined using two experimental animal designs, one for acute inflammation (rat paw edema) and the other for chronic inflammation (granuloma pouch) on eighty adult albino rats. The results obtained were statistically analyzed. Results: The data showed physicochemical compatibility between the drug and the polymers used. The LX patches (F1, F2, and F3) prepared were uniform thickness, drug content, and the pH of...
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Posted by admin on Oct 1, 2014 in |
A simple, rapid, and sensitive high-performance liquid chromatographic method with UV detection has been developed and validated according to the ICH guidelines for the quantization of Ceftriaxone (CEF) and Sulbactam (SUL) in parenteral preparation. Chromatographic separation was carried out in a Hypersil Gold C8 column (250 mm × 4.6 mm; 5 μm particle size) of Thermo Scientific with simple mobile phase composition of 10 ml of 40% Tetra Butyl Ammonium Hydroxide(TBAH) in 1000 ml of water (pH 5.5, maintained by dil Phosphoric acid) and acetonitrile (70:30, v/v) at a flow rate of 2.0 ml min-1 with injection Volume of 20 µl where detector was set at 227 nm with a total run time of 10 min. The method was linear over the concentration range of 40-100, μg ml-1 for SUL and 80-200 μg ml-1 with a correlation coefficient of 0.999 and 0.999 respectively. Limit of quantifications (LOQ) of 8.5, 14.4 and limit of detections (LOD) 2.8, 4.7μg ml-1 for CEF and SUL respectively. Accuracy and precision values of both...
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Posted by admin on Oct 1, 2014 in |
A simple, sensitive, cost-effective spectrophotometric method has been developed and validated for the determination of Ambroxol hydrochloride (AMB), in bulk drug and its pharmaceutical formulations. The method is based on the formation of a Schiff base with PDAB; the reaction of drug with reagent gives a bright yellow color. The so formed colored species absorbance was measured at its absorption maximum (λmax) 423 nm. Beer’s law has been obeyed in the concentration range 5-30 µg/ml. The optical parameters were calculated as 2.0702 × 104 (L/mol/cm), 0.0183 (µg/cm2), molar absorptivity and Sandell sensitivity respectively. The LOD and LOQ of the proposed method were calculated 0.0844 (μg/ml), 0.2812 (μg/ml), respectively. All the variables were studied to optimize the reaction conditions. No interference was observed in the presence of common pharmaceutical excipients. The validity of the method was tested by analyzing AMB in its pharmaceutical formulations and critically tested for its accuracy by statistical tests. Good recoveries were obtained by the developed method; the obtained results were critically analyzed and successfully employed...
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