Posted by admin on Mar 31, 2025 in |
Rheumatoid arthritis (RA) is a chronic inflammation disorder that primarily affects the joints and leads to the progressive destruction of joints, synovial hyperplasia bone, and cartilage degeneration. Globally 1% of the world population was affected by rheumatoid arthritis. The present study focused to identify the bioactive phytocompounds of polyherbal formulation- Erandadi Kwatham and to determine its potential in inhibiting the targets TNF-α and Hk-II, which are associated with rheumatoid arthritis. The 3D structure of the phytocompounds were retrieved and analyzed for its physicochemical properties, toxicity, and drug-likeness were determined using the Qikprop module in maestro Schrodinger software. Among, only six compounds satisfied the ADME properties and followed drug-likeness. Further the phytocompounds triethyl citrate (6506), butanedioic acid, hydroxyl diethyl ester (24197), L-Valine, ethyl ester (87182), phenylacetic acid (97942), 7-trihydroxy-1-methyl – 8 – methylene-1, 4a-lactone-10-methyl (539615), and pectolinarigenin (5320438), were analyzed using molecular docking studies against the protein targets, TNF-α and Hk-II. The compounds triethyl citrate and pectolinarigenin were observed with significant binding efficiency of -3.47 and -5.88 kcal/mol against the...
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Posted by admin on Mar 31, 2025 in |
Psychogenic non-epileptic seizures (PNES), which intently look like epileptic seizures (ES), are regularly set off by mental trouble and address the most pervasive type of change issue experienced in clinical practice. Different states of being can both encourage and support PNES episodes. PNES episodes. Epilepsy, a common neurological disorder, imposes significant emotional and physical burdens, frequently resulting in elevated levels of anxiety and depression. This case report details the clinical course of a 25-year-old female diagnosed with PNES. The patient background of childhood trauma, early marriage, and depression likely predisposed her to the development of PNES upon diagnosing with epilepsy, characterized by seizure and depression, the patient experienced increased anxiety, irritability, loss of consciousness, and required hospitalization. Her treatment regimen of intravenous administration of Injection Levetiracetam 500 mg and oral olanzapine 2.5 mg to her seizures persisted. On evaluation of electroencephalography EEG and CT scan indicated the epilepsy and Panes. Although the surgical intervention was unnecessary, the management of epilepsy with ongoing pharmacotherapy significantly reduced her PNES episodes. This...
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Posted by admin on Mar 31, 2025 in |
Oral candidiasis (OC) is a common fungal infection characterized by white patches on the oral mucosa, often triggered by factors like immunosuppression and medication use. It can affect anyone, regardless of age or background. The formulation of mucoadhesive gels for the treatment of oral candidiasis is a promising area of research. The gel enhances the residence time of the drug at the site of infection, thereby improving therapeutic efficacy. This study aimed to develop a mucoadhesive gel for oral candidiasis treatment using an inclusion complex of itraconazole and beta-cyclodextrin. Different concentrations of mucoadhesive polymers (Carbopol 940) and absorption enhancers (Poloxamer 188 and propylene glycol) were used. The pH of the gels ranged from 6.5 to 7.2. The viscosity varied between 300 and 600 cps. The gelation temperature was 30°C to 35°C. Spreadability ranged from 4.7 to 4.83 cm. The drug content was found to be 90% to 95%. Mucoadhesive force ranged from 3549 to 3917 dyne/cm2. Drug release lasted 6 hours, with 95 to 99% cumulative release. In-vitro antifungal...
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Posted by admin on Mar 31, 2025 in |
The aim of present study was to develop microemulsion formulation of apremilast for the topical treatment of nail psoriasis, a challenging condition due to the nail’s dense structure limiting drug penetration. Apremilast, a PDE4 inhibitor, offers an effective systemic approach but faces bioavailability challenges and potential side effects when administered orally. To address these issues, apremilast-loaded microemulsion was formulated using oleic acid, Tween 80 and PEG 600, optimized through a Box-Behnken design. The resulting microemulsion exhibited desirable characteristics, including particle size, PDI, and zeta potential, indicative of stability and effective drug delivery. In-vitro studies revealed an 81.63% drug release over 24 hours, highlighting the formulation’s sustained release capabilities. Ex-vivo transungual permeation tests using goat hoof membranes further supported enhanced drug permeation to the target site, outperforming the pure drug suspension. These findings suggest that apremilast-loaded microemulsion can provide a more targeted, efficient, and safer alternative for nail psoriasis therapy, improving patient compliance through topical application. This novel approach has potential implications for enhanced nail disease management and future topical...
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Posted by admin on Feb 28, 2025 in |
This study focuses on developing clindamycin phosphate-loaded calcium carbonate nanoparticles to treat osteomyelitis, utilizing the chemical precipitation method. These nanoparticles were optimized for particle size, zeta potential, drug content, and encapsulation efficiency, resulting in seven different formulations (F1-F7), with formulation F5 was identified as the most effective. Particle size ranged from 275.9 nm to 846.5 nm, and a high homogenization speed of 15,000 rpm was crucial in achieving smaller particle sizes conducive to better bone cell attachment. The zeta potential of -18.8 mV suggested good stability and potential for enhanced interaction with osteoblasts. The optimized formulation F5 exhibited high drug loading (87.56 %) and entrapment efficiency (85.36 %), with FESEM analysis confirming their favorable characteristics for drug delivery. The drug release profile followed a sustained pattern, with 69.60 % of the drug released over 8 hours, adhering to the Higuchi model of quasi-Fickian diffusion. The antimicrobial efficiency tests showed that these nanoparticles could maintain similar inhibitory concentrations against S. aureus as the standard clindamycin phosphate solution, indicating effective drug...
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