Posted by admin on May 31, 2025 in |
In paediatric critical care settings, the use of sedatives is common for managing pain, agitation and anxiety. However, prolonged administration of sedatives can lead to iatrogenic withdrawal syndrome, posing significant challenges in patient care. This study investigates the risk factors associated with iatrogenic withdrawal syndrome in paediatric critical care patients and explores effective management strategies through analysis of clinical data, type of sedative used for underlying medical condition, exposure of sedation, number of sedatives used, RASS (Richmond Agitation Sedation Scale) and (withdrawal assessment tool) WAT-1 score. Our study reveals that infants and males are more prone to IWS. Most patient produced with tachycardia and gave clonidine as treatment plan. We also did comparison between patient produced with IWS and no IWS. By understanding the risk factors and implementing evidence-based management strategies, healthcare providers can optimize the care of paediatric critical care patients and minimize the occurrence and impact of iatrogenic withdrawal...
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Posted by admin on May 31, 2025 in |
Introduction: Obesity is condition wherein a person starts to gain unnecessary body fat.” Obesity in children has reached epidemic levels in developed & its prevalence is increasing in developing countries as well. The identification of parental health knowledge related to obesity and overweight status in children is an important area. Its importance relates to understanding gaps in knowledge that can be used to create targeted intervention and prevention strategies to improve the management of child’s health. Methodology: Quantitative research approach & Pre experimental one group pre & post-test design was used to conduct the present study. Non Probability Purposive Convenient sampling was used to collect data among 60 parents of school going children of Kendriya Vidyalaya, SGPGIMS, Lucknow. Result: The overall knowledge level of parents of school age children regarding childhood obesity, it shows that (1.66%) parents had good knowledge, (35%) had average knowledge and (63.3%) had poor knowledge. The mean and standard deviation of Pre-test knowledge score is 4.91, 2.59. The overall score of post-test knowledge regarding childhood...
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Posted by admin on May 31, 2025 in |
The present research work is aimed to formulate and evaluate Nitrendipine nanosuspension (NTD-NS) and nanosuspension loaded oral fast dissolving film (NS-OFDF) to improve its low solubility and bioavailability. Wet media milling technique was employed to prepare NTD-NS, which was optimized and evaluated for different parameters. Poloxamer 188, Poloxamer 407, HPC, HPMC E5, HPMC E15, HPMC E50, HPMC K4M, PVP K30 were used for preparing various nanosuspension formulations. HPMC E15 and SLS were used to formulate optimized nanosuspension. NTD-OFDF was prepared using the optimized nanosuspension by solvent casting method. PEG 400 is added during film formation as plasticizers and HPMC is added as film former polymer. The NTD-OFDF were prepared, optimized and evaluated for different parameters. Optimized NTD-NS depicted particle size of 455.2 nm with polydispersity index (PDI) of 24.9% and zeta potential of -24.2 mV. Optimized NTD-OFDF exhibited surface pH of 7.12±0.0251, folding endurance of321±4, thickness of 0.171±0.003, disintegration time of 28.133±0.493 sec which was in the standard limits. The drug release from NTD-NS loaded OFDFs increased significantly, reaching...
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Posted by admin on May 31, 2025 in |
Antimicrobial resistance continues to cause antibiotics treatment failure and millions of deaths globally. Inhibition of a double-stranded binding protein-A enzyme (DsbA), machinery in bacteria resistance and pathogenesis mechanisms make the bacteria vulnerable to existing antibiotics, allowing restoration of antimicrobial efficacy. However, there is a gap in identifying bioactive and safe DsbA-inhibitors as a therapeutic restoration strategy. In this in-silico screening study, a co-crystallized E. coli-DsbA enzyme protein was used as the target. Seven bioactive ligands: linoleic acid, aloesin, azadirachtin, nimbin, palmitic acid, stearic acid, and aloeresin-A, showed maximum docking scores of low binding affinity (kcal/mol): -6.8345, – 5.9434, – 7.2810, -6.2394, -6.5958, -6.7170 and -6.9554 respectively, lower than the standard (9AG): -4. 6919. The ligands obeyed Lipinski’s rule of 5. The Root Mean Square Deviation (RMSD) of E. coli-DsbA complexes with azadirachtin, and aloeresin-A displayed remarkable stability throughout the simulations. Molecular dynamics simulation on azadirachtin and aloeresin-A showed great docking scores and modes over 10000ps and revealed lowest binding affinity scores, remain stable in the active site. Additionally, astructural-activity...
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Posted by admin on May 31, 2025 in |
Objective: The present investigation demonstrates a simple, sensitive and accurate high-pressure liquid chromatographic (HPLC) method for the determination of Alvimopan (AMP) in bulk and dosage form. The chromatographic separation was achieved within 10 minutes by using acetonitrile: potassium dihydrogen phosphate buffer pH 3.0 adjusted with orthophosphoric acid (50:50) as mobile phase on Altima Grace Smart C-18 column (5μ; 250 × 4.6 mm) at flow rate of 1.0 ml/min with injection volume 20µL at wavelength of 261nm. The retention time of the drug was found to be 5.02 min. This method was validated as per United States Food & Drug Administration (US-FDA) guidelines. The results of the validation parameters were found to be within the acceptance limits. The method was linear in the concentration range from 500-20000 ng/mL (r2 = 0.9998) and the accuracy of drug was found to be 95.83-104.63% for AMP. The lower limit of quantification was found to be ng/ml and the stability of recovered samples at different conditions was found to be more than 95%. The...
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