Posted by admin on Jun 1, 2012 in |
Plants have been used in traditional medicine for several thousand years. India is perhaps the largest producer of medicinal herbs and is rightly called the “Botanical garden of the World”. Murraya koenigii Linn. commonly known as Meethi neem, belongs to the family Rutaceae. The curry tree is native to India and it is found almost everywhere in the Indian subcontinent excluding the higher levels of Himalayas. The effect of Murraya koenigii leaves aqueous extract on biophysical and biochemical parameters of wound were studied by dead space wound model in diabetic hyperlipidemic rats. In dead space wound model, animals treated with Murraya koenigii (oral administration of variable dosage level 200mg/kg, 300mg/kg and 400mg/kg) leaves aqueous extract showed significant increase in Wet & Dry granulations tissue weight (biophysical parameter) and hydroxyprolin content (biochemical parameter) when compared to the diabetic hyperlipidemic control group rats. In this study, very significant (p<0.001) result was found with 300mg/kg dose level because the effect was dose dependent up to 300mg equivalent of extract. The results suggested...
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Posted by admin on Jun 1, 2012 in |
The in vitro dissolution studies of encapsulated sodium salicylate granules coated with beeswax is presented. The factors investigated were the effects of concentration, presence of a hydrophilic fatty material, polyethylene glycol 6000 (PEG 6000), and technique (pan-coating, fusion and granulation) on the sustained release of drug when coated with beeswax. Comparison of release rates was based on the use of a parameter, t70% (time for 70% of drug to be released). The greater the concentration of beeswax, ranging from 13.04 to 28.75%, the more prolonged the release. The presence of PEG 6000 at a concentration of 1:9 beeswax in the coating fluid significantly (p<0.05) increased the release rate, and at a concentration of 1:1 nullified the sustained release effect of beeswax. The t70% for the fusion, granulated and pan-coated batches were in the increasing order of 25min., 1hr.35min. and 2hr.45min,...
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Posted by admin on Jun 1, 2012 in |
Background: Hypertension is an immensely pervaded problem in today’s population and is a unanimous major risk factor for heart diseases. Various natural herbs have been found to control the hypertension exquisitely without causing any significant adverse effect. Eclipta alba (EA) and Boerhaavia diffusa (BD) are two herbaceous plants. EA is used to treat hepatic-dysfunction, hair diseases and anemia since ancient time. Similarly, BD is a great treatment-option for renal and urinary disorders. They have also been found quite effective in the safe treatment of hypertension. But studies in this respect are very scanty and confirmatory role of these herbs in hypertension is yet to be established. In the present study, effects of EA and BD on normal blood pressure (NBP) and hypertension were studied. Their antihypertensive activities were also compared with those of Amlodipine (Amlo). Methods: Adult Wistar rats of both sexes, weighing 140-150 g were randomized equally to make 9 groups (6 rats/ group). First 6 groups were given high fat diet for 49 days to produce hypertension....
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Posted by admin on Jun 1, 2012 in |
This present investigation was an attempt to an ethno botanical survey which was carried out by the local practitioners of Coimbatore district in Tamil Nadu. During the survey 48 medicinal plant leaves are identified which were used as medicine for several diseases either in single or in combination with some other ingredients. In the first phase the Botanical Name, Family, Local Name and uses of leaves have been discussed and noted....
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Posted by admin on Jun 1, 2012 in |
Two triterpine acids like 2α, 19α- dihydroxy – 3-oxo-12- ursen- 28-oic acid (1), 2α, 16α, 19α- trihydroxy – 3-oxo-12- ursen- 28-oic acid (2) were isolated from the n-hexane soluble fractions of a methanol extract of the root of Albizzia lebbeck Benth. The structures of the isolated compounds were elucidated as by extensive spectroscopic studies, including high field NMR analyses. This is the first report of isolation of compounds 1- 2 from this...
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