Posted by admin on Jul 1, 2012 in |
Ethnopharmacological relevance: Calotropis gigantea is usedtraditionally to treat common diseases such as fever, rheumatism, indigestion, cough, cold, eczema, asthma, elephantiasis, nausea, vomiting and diarrhoea, either alone or with other medicines Aim of the study: To evaluate the antivenom activity of Calotropis gigantea plantextract against Vipera russelli snake venom Materials and methods: The lyophilized snake venom of Vipera Russelli was dissolved in saline and required concentrations were prepared. Lyophilized polyvalent snake venom antiserum was used as reference serum. The methanolic extract of Calotropis gigantea was evaluated for its efficacy to neutralize various actions of the venom like lethality, necrotizing activity, edema forming activity and haemorrahgic activity. Results: Oral administration of C. gigantea plant extract at dose levels 200 and 400 mg/kg body weight effectively neutralized the lethal effect of 2LD50 and 3LD50 of V. russelli venom in mice (in-vivo neutralization). In in-vitro studies, the plant extract at all dose levels, i.e. 100, 200 and 400mg/kg body weight effectively neutralized 2LD50 and 3 LD50 of Vipera russelli venom. Oral administration of...
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Posted by admin on Jul 1, 2012 in |
Heterocyclic Compounds having a valuable place in a Heterocyclic Chemistry and Heterocyclic Compounds having an excellent properties such as drugs, dyes etc, These compounds shows anti-microbial, anti-fungal, anti-bacterial, anti-inflammatory, anti-diabetic, anti-hypertensive etc. properties. In present investigation, we have prepared 2-4-{[(substitutedphenyl)imino]methyl} phenoxy)acetohydrazide from amine of (4-{[substitutedphenyl)imino] methyl}phenoxy)acetic acid and Hydrazine hydrate in presence of ethanol. The intermediate (4-{[(substitutedphenyl)imino]methyl} phenoxy) acetic acid from (4-formylphenoxy)acetic acid and substitutedaniline by using ethanol as a solvent. Compound having an excellent properties regarding as per as anti cancer and HIV as compare to this compound. Physical properties of pure crystallized substance 2-4-{[(substitutedphenyl) imino]methyl}phenoxy) acetohydrazide like M.P., elementary analysis and spectral data of compound and such as IR and NMR will be evaluated and confirm the structure of...
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Posted by admin on Jul 1, 2012 in |
Averrhoa bilimbi Linn. (Family: Oxalidiaceae) is a medicinal plant which is extensively used in traditional medicine to cure cough, cold, itches, boils, rheumatism, syphilis, diabetes, whooping cough, and hypertension. In this study, hydromethanolic extract of A. bilimbi fruits was examined for its antioxidant action using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and total antioxidant capacity. Total phenol and flavonoid contents of the extract were also estimated. Moreover, brine shrimp lethality bioassay was used to investigate the cytotoxic potential of A. bilimbi. The extract exhibited strong DPPH radical scavenging activity with and IC50 value of 20.35μg/ml as opposed to the IC50 value of the reference standard, ascorbic acid (12.6μg/ml). It also displayed remarkable total antioxidant capacity (417.093±6.577mg/g in ascorbic acid equivalent (AAE)). Total phenol and total flavonoid contents of the extract were 106.16±2.818 mg/g in gallic acid equivalent (GAE) and 276.73±25.25 mg/g in quercetin equivalent (QE), respectively. A. bilimbi fruit extract also showed strong cytotoxic potential with an LC50 value of 5.011μg/ml in brine shrimp lethality bioassay. Our results suggest that,...
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Posted by admin on Jul 1, 2012 in |
Indian Gooseberry, Emblica officinalis is a, fruit widely accepted in Kerala for its medicinal & nutritive values. The fruit has dark green colored spherical seed surrounded by pale green colored tissue. Different varieties of food products, pickles being the major one, are used all over the world .The present work on gooseberry originated from a real medical case history. The medical reports say that a normal person who was eating gooseberry on a normal course all at a sudden became allergic only to this fruit since two years. This person was hospitalized two times for anti- dot injection as the allergic symptoms go beyond control. The major symptoms the patient showed are; (a) itching; (b) swelling of the whole bodily parts & (c) drowsiness. These allergic effects were due to gooseberry and which confirmed by medical examination. Based on our preliminary information, allergy due to Indian gooseberry was the first case reported in our locality. This made our interest to investigate further the chemistry & physiology of allergic reactions...
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Posted by admin on Jul 1, 2012 in |
Lornoxicam, a widely prescribed anti-inflammatory and analgesic drug belongs to class II under BCS and exhibit low and variable oral bioavailability due to its poor aqueous solubility. It is practically insoluble in water and aqueous fluids. As such its oral absorption is dissolution rate limited and it requires enhancement in solubility and dissolution rate for increasing its oral bioavailability. The objective of the present study is to enhance the solubility and dissolution rate of lornoxicam employing Hydroxy propyl β-cyclodextrin (HPβCD) and two surfactants (SLS and Tween 80) alone and in combination. The individual main effects and combined (interaction) effects of HPβ-cyclodextrin and surfactants on the solubility and dissolution rate of lornoxicam were evaluated in a series of 22 factorial experiments. The solubility of lornoxicam in the four selected fluids as per 22 factorial study in each case was determined (n=4). Lornoxicam-βCD-surfactant inclusion complexes were prepared employing the selected combinations of HPβCD and surfactant in each case as per a 22 factorial design and the inclusion complexes prepared were evaluated...
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