Posted by admin on May 1, 2012 in |
A simple and sensitive spectroscopic method was developed for the estimation of Racecadotril in pharmaceutical dosage forms. This method is based on Racecadotril, showing absorbance at 231 nm in methanol. This method obeys Beers law in the concentration range of 8 to100 μg mL-1 respectively. The proposed method is precise, accurate and reproducible and can be extended to the analysis of Racecadotril in bulk and tablet formulations. The method was linear (r=0.9998) at concentrations ranging from 8 to 100 µg ml-1, precise (repeatability and intermediated precision), exact (method of standard addition), and Limit of detection µg ml-1 (0.088749). Limit of quantification µg ml-1 (0.268938) was found and the % recovery is found...
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Posted by admin on May 1, 2012 in |
Alzheimer’s disease (AD) is a progressive degenerative disease of the brain marked by gradual and irreversible declines in cognitive functions. Acetylcholinesterase plays a biological role in the termination of nerve impulse transmissions at cholinergic synapses by rapid hydrolysis of acetylcholine. The deficit levels of acetylcholine lead to poor nerve impulse transmission. Thus the cholinesterase inhibitors would reverse the deficit in acetylcholine levels and consequently reverse the memory impairments characteristic of the disease. In the present work, functionalized coumarin compounds and their derivatives were docked into active site of Acetylcholinesterase using the docking programs GOLD and GLIDE. The compounds were screened using High throughput screening, and further subjected to Induced Fit Docking studies. Further, the QSAR studies revealed the best structure activity relationship and 100% of human oral absorption. The inhibitor compounds also satisfied the PASS (Prediction of Activity Spectra for Substances) results of inhibiting the activity of acetylcholinesterase. The type of interaction they exhibit and the residues with which they interact convey that both the compounds are good inhibitors...
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Posted by admin on May 1, 2012 in |
The in vitro dissolution property of slightly water soluble Fenofibrate (FN) was improved by exploring the potential of Liquisolid system (LS). The in vitro release pattern of LS compacts and directly compressed tablets were studied using USP-II apparatus. Different LS compacts were prepared using a mathematical model to calculate the required quantities of powder and liquid ingredients to produce acceptably flowable and compressible admixture. Avicel PH 102, Aerosil 200 and Explotab were employed as carrier, coating material and disintegrants respectively for preparing LS compacts. The prepared LS compacts were evaluated for their flow properties such as bulk density, tapped density, angle of repose, Carr’s compressibility index and Hausner’s ratio. The interaction between drug and excipients in prepared LS compacts were studied by differential scanning calorimetry (DSC) and X- ray powder diffraction (XRPD). The drug release rates of LS compacts were distinctly higher as compared to directly compressed tablets, which show significant benefit of LS in increasing wetting properties and surface area of drug available for dissolution. The LS-1 of...
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Posted by admin on May 1, 2012 in |
The study was designed to evaluate the cardioprotective effect of methanolic extract of Morus alba L. leaves against isoprenaline- induced myocardial infarction and was investigated by an in vivo method in rats. Male Wistar albino rats were divided into four groups (n=6). Group I rats served as normal control. Group II rats served as isoprenaline induced toxic control (110 mg/kg body weight) which was injected intraperitoneally (i.p.) for two consecutive days (14th and 15th days). Group III rats were given Morus alba intragastric intubation (500 mg/kg body weight) for 15 days. Group IV rats were also given Morus alba as in Group III and additionally isoprenaline was given for two consecutive days (14th and 15th days).The results described the cardioprotective effect that was observed in Group IV which showed a significant (P< 0.05) decreased levels of TBARS and enhanced the activities of both enzymatic and non-enzymatic antioxidants (SOD, CAT, GPx and GSH) in myocardial infarcted rats when compared to Groups II and III. In serum, the biomarkers (LDH, CK)...
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Posted by admin on May 1, 2012 in |
Polymethyl mehtacrylates polymers such as Eudragit RL100 have been used in preparation of matrix type oral sustained release, coating and in microencapsulation of drug. Embedding of drug within an insoluble matrix is convenient way of controlling the drug release.The prepared microspheres by emulsion solvent evaporation technique was simple and reproducible, possessed good sphericity, smooth surface morphology, uniform and narrow size distribution (170-200 μm), when analyzed by scanning electron microscopy, and optical microscopy. Method of preparation has influenced the particle size and drug loading efficiency. The carrier ethyl cellulose and Eudragit RL100 are easily available and compatible. Drug-polymer compatibility was confirmed by Fourier transform infrared spectroscopy and DSC and X-ray diffraction studies revealed that the drug was dispersed inside the microspheres in the form of an insoluble matrix. The formation of microspheres was affected by glass transition temperature of the polymer, surfactant, type of plasticizers, volume of internal phase, stirrer speed etc. IR of Eudragit RL indicated high thermal stability of the polymer. Percentage loading increases with the increase in...
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