Posted by admin on Dec 31, 2022 in |
The objective of this study is to investigate the protective effect of aqueous bark extract of Terminalia arjuna (TA) on high-fat diet-induced cardiovascular changes in Wistar rats using histological, immunohistochemical, and gene expression analysis. Group 1- without treatment served as control, group 2- High fat diet (HFD) received corn oil orally at a dose of 10 mL/kg, group 3 – HFD+atorvastatin (ATV) – 10 mg/kg, group 4 – HFD+TA125 mg/kg , and group 5- HFD+TA250 mg/kg, 6 days a week for 5 weeks. The activity of MMP-9 was measured in blood, Hematoxylin and Eosin staining was analyzed with heart tissue and TNF-α immunohistochemistry and ADIPOQ gene expression analysis were conducted using heart tissue. When Compared to the control group, the HFD group showed higher levels of MMP-9 activity and morphological changes in heart histology. TNF-α expression was also significantly increased in HFD group and down-regulation of ADIPOQ gene expression levels. MMP-9 activity and pathological damage to cardiac tissue including ADIPOQ gene expression were significantly reverted when T. arjuna bark...
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Posted by admin on Dec 31, 2022 in |
Begonia cucullata Willd. (Begoniaceae) is a native medicinal species from Paraguay popularly used to combat stomatitis, pharyngitis, respiratory ailments in children, and inflammatory conditions among others. The limited literature did not report these plants as having analgesic, anti-inflammatory, or antimicrobial properties. This work aims to determine the acute toxicity, general behavior, analgesic, and anti-inflammatory activities in mice and antimicrobial activity in-vitro of crude extract of B. cucullata (CEBc). Experimental induced-pain models (Randall-Selitto, Writhing, and Hot plate test) were used for the study of analgesia in mice. Likewise, carrageenan-induced paw edema was used to evaluate the anti-edematous activity of CEBc. CEBc is safe, well-tolerated, and without behavioral effects in mice and is devoid of antibacterial activity. Using the Randall-Selitto method, oral doses of CEBc denoted a significant increment in the pain threshold up to 260 %. Also, in the writhing test, the number of abdominal contortions was significantly decreased up to 68% by CEBc in a dose-dependent manner in comparison to the control group. Likewise, oral administration of CEBc in...
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Posted by admin on Dec 31, 2022 in |
Metformin (MET) is a biguanide class of oral hypo-glycaemic agent which is used in the treatment of diabetes mellitus type II. Currently, MET is the first drug of choice and is primarily prescribed by medical practitioners to at least 120 million people worldwide. The quality-oriented routine analysis of various commercially available products of MET is a major challenge. Several methods have been reported in an industrial scale for thorough quantitative analysis. This review article comprehensively examines the published sophisticated instruments-based nearly 50 analytical methods in various pharmaceutical databases like Google Scholar, PubMed, etc. of diverse area of High-Performance Liquid Chromatography (HPLC). The determination of MET in plasma, serum, and urine, extensively requires the HPLC method. For the determination of MET in biological samples, we recommend the LC-MS/MS method since this method combines the HPLC separation ability with MS sensitivity and selectivity, allowing the identification of MET and its metabolites. For pharmaceutical analysis, HPLC with UV detection method is applicable because this method provides accurate results and low cost compared...
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Posted by admin on Dec 31, 2022 in |
The eye is one of the most sensitive organs of human body and is continuously exposed to different environmental agents so it is very important to take care of eyes. Poor vision makes it harder to read, drive, and cook. Many eye problems and diseases can be treated if caught early. Ophthalmologists will examine eyes for signs of vision problems or eye diseases. It’s the best way to find out if glasses or contacts are needed in the early stages of a serious but treatable eye disease. Wearing protective eyewear when playing sports or doing activities around the home, smoking cessation, wearing UV radiation-blocking sunglasses, Cleaning hands and contact lenses properly to avoid the risk of infection, etc., are the steps to protect...
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Posted by admin on Dec 31, 2022 in |
Nanoparticles with lipids as a constituent are called “solid lipid nanoparticles” (SLNs). Based on the most recent trends, SLNS is a promising approach for overcoming multiple barriers in drug delivery. Through SLNs, maximized drug payload to the site of action for different pharmaceutical drugs can be achieved. They range in size from 10nm to 1000nm and possess a solid lipid core matrix that aids in the solubilization of lipophilic compounds. The evolution of multidrug resistance therapy against various chemotherapeutic agents, tissue toxicity, and a high prevalence of drug-resistant tumors are the most common impediments in the clinical management of cancer. For more than a decade, SLNs have been widely used as drug delivery systems in the treatment of various cancers due to their low toxicity, high drug bioavailability, and usefulness with hydrophilic and lipophilic drugs. In this review, we discussed the incorporation and controlled delivery of different cytotoxic anti-cancer drugs to target sites using SLNs to treat various...
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