Posted by admin on Feb 28, 2023 in |
The heterocyclic compounds are formed by the hetero atoms (O, S, N, etc.) in the cyclic ring system. These are mainly started from 3- membered to 10- membered heterocyclic rings. The compound containing heterocyclic molecules shows potent activity in various pharmacological targets. Benzothiazole is a fusion of a benzene ring with a 5-membered thiazole ring which is widely used in heterocyclic compounds. The benzothiazole pharmacophore and its derivatives are used for the development of novel drugs and have also shown different pharmacological and biological activities such as anticancer, antibacterial, antifungal, anti-inflammatory, analgesic, anti-HIV, antioxidant, anticonvulsant, antitubercular, antidiabetic, antileishmanial, antihistaminic, antimalarial activities. In previous years, few new benzothiazoles have been shown with different biological responses. In such a manner, this review illuminates the benzothiazole and its substituted product that possesses distinct biological activity. This article discovered a novel benzothiazole-based drug that has shown less toxic and more active...
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Posted by admin on Feb 28, 2023 in |
Coumarin and its derivatives are widely used as scaffolds in synthesizing new heterocyclic systems. Numerous approaches especially involving nano-particle catalysts, have been developed to get new bioactive coumarin derivatives endowed with pharmacological and biological activities. The present work describes the reactivity and the new strategies for the synthesis of coumarin and its derivatives reported in the literature and their biological properties. Coumarins possess a number of biological activities like Anticoagulant, Antimicrobial, Anti-inflammatory, Analgesic, Antioxidant, Anticancer, Antiviral, Anti-malarial etc. Coumarin belongs to a group as benzopyrones, which consists of a benzene ring joined to a pyrone nucleus 12. Coumarins (2H-1-benzopyran-2-ones) are important oxygen-containing fused heterocycles used in drugs and dyes. A number of coumarin derivatives have been reported to have diverse biological activities like fungicidal1-4, molluscicidal 2, antihelminthic 5, 6 and CNS 7 stimulants. Mannich Bases of some heterocyclic compounds are also reported Bioactive 8, 9. In view of this Mannich bases of 7 – hydroxyl – 4 – methyl coumrin and 4, 6, 7– trimethyl coumaryl incorporating various DL–amino...
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Posted by admin on Feb 28, 2023 in |
Phytomedicines from herbal plants are widely used as a home remedy in ancient times to maintain the normal health of human beings. As per World Health Organization (WHO) estimation, nearly 75-80% of the population in the world utilizes medicinal plants for their primary health care. Duranta erecta itself has antioxidant and anti-microbial activities and has been used in Africa and Asia to treat a wide range of diseases. Evaluation of the study is based on the phytochemical profile, anti-microbial and antioxidant activities of D. erecta to ascertain its health benefits in traditional medicine. Plant parts with antimalarial, anti-bacterial, antioxidant, anthelminthic, antifungal, antiparasitic, insecticidal, and cytotoxic activity have been reported to include leaves, fruit, stems, and flowers. Fruit, flowers, leaves, and stems were screened for the presence of phytochemicals such as iridoid glycoside, alkaloids, flavonoids, saponins, terpenes, tannins and sterols, C-alkylated flavonoids beta-sitosterol, naringenin, triterpenes saponins, steroidal glycosides. Plant extracts of D. erecta leaves that have antioxidant activities show potential effects in many conditions initiated by oxidative stress. This review reveals...
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Posted by admin on Feb 28, 2023 in |
Background: Shivering is one of the most troublesome and distressing experiences for the patient encountered intraoperatively following spinal anaesthesia. Tramadol is very commonly used in clinical practice for post-spinal shivering but has side effects. The study aimed to compare the efficacy of dexmedetomidine with that of tramadol for prophylactic use in post-spinal anaesthesia shivering. Methods: A prospective, randomised controlled study was conducted on 210patients (American Society of Anaesthesiologists class I and II) of either gender, aged between 18 and 65, scheduled for elective lower abdominal and lower limb surgeriesunder spinal anaesthesia. The patients were randomized into three groups of 70 patients each. Group D received dexmedetomidine (0.5 µg/kg in 100 ml NS), Group T received tramadol (0.5 mg/kg in 100 ml NS) and Group C received 100 ml NS. All the drugs were given as an infusion over 10 min.The incidence and severity of shivering were recorded at 0min, 5min, 10min, 15 min and then every 15min till the end of surgery. The data was analyzed using IBMSPSS20 for...
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Posted by admin on Feb 28, 2022 in |
Objective: Our work was to develop an ordispersible tablet of Dextromethorphan HBr with acceptable palatability to help patients of all age groups. Methods: The bitter taste of the drug was masked by entrapping the drug into Eudragit RL 100. The microspheres were prepared from solvent evaporation method. The effect of particle size, drug entrapment efficiency, % yield and % drug release of the microspheres was studied. Drug loading increased significantly with increasing the drug polymer ratio. Dextromethorphan was than further transformed into orodispersible tablet by using Hibuscus and Fenugreek as a superdisintegrants by using direct compression method. Physiochemical parameters and animal toxicity study of dried mucilage obtained from Hibiscus and Fenugreek were performed. In-vitro disintegration and in-vitro dissolution was carried out to observe the disintegration time and sustain release of drug. Results: In-vivo taste masked study was performed on albino rats. SEM, DSC and FTIR were done for identification, compatibility study and surface morphology. The or dispersible tablet made from sustained release microspheres showed release up to 10 h....
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