Posted by admin on Mar 31, 2022 in |
Natural molecules from plants are vital sources to explore potent lead molecules in the drug discovery process. Plants as A source of medicine is an ancient practice in India. The Indian subcontinent is a wide repository of medicinal plants that are being used in the traditional system of medicines. Kalanchoe is one of the medicinal plants; the succulent leaf juice is prepared by grinding the leaves mechanically and is a Tyler-made medicine being prescribed by traditional practitioners to combat various diseases and disorders. Various species of Kalanchoe find an important place in traditional medicine across the globe. This review article is a systematic compilation of recent updates on the worldwide ethnopharmacological uses and phytomolecules as therapeutic markers, pharmacological profiles, pharmacokinetic studies and SAR of bufadienolides from varied species of Kalanchoe. The systematic compilation of review articles will direct the scientific community to focus their research by doing further molecular and targeted throughput screening of the lead molecules from Kalanchoe, results in drug discovery from the potent herbal plant Kalanchoe....
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Posted by admin on Mar 31, 2022 in |
Tea brewed from the plant Camellia sinensis is the second most popular beverage consumed worldwide after water. The first two leaves and the leaf bud are mainly used for commercial tea production, and depending on the variation of processing techniques, it is primarily categorized into -white tea, green tea, oolong tea, and black tea. Different varieties of tea are known for their contribution in little to a large amount of bioactivity or sensory attributes due to variation in the chemical constituents, thus providing health benefits. Throughout the years green tea has been extensively investigated by researchers for its health benefits; however, black tea is now emerging as more beneficial to health and catching serious attention by researchers. Apart from the methylxanthines, amino acids, phenolics, and catechins, the two major components, i.e., the TFs and TRs are solely responsible for black tea’s characteristic color and taste and are proven to have health benefits. This review aims to provide available information on Theaflavins (TFs), their bioactivity, and, most importantly, the various...
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Posted by admin on Mar 31, 2022 in |
Copper is an essential trace element involved in a plethora of functions being a component of several enzymes. Copper deficiency affects people of all age groups, including infants, children, pregnant women, and men. Deficiency occurs due to numerous factors hindering the absorption/uptake of copper. Male Wistar rats (35-50 gm) were divided into four groups: Group 1: Negative control – fed with standard feed (Ashirwad Industries, Chandigarh) and tap water was provided ad libitum .Group 2: Copper control group- Fed with diet containing 126 nmol Cu/gm. Tap water was provided ad libitum. (c) Group 3: Pair-fed group – Fed with 126 nmol Cu /gm diet but the amount of feed given was equal to the feed consumed by the copper-deficient group the previous day to account for stress and starvation effect caused due to low intake diet. Tap water was provided ad libitum (d) Group 4: Copper deficient- animals were fed with 6.3 nmol Cu / gm diet, and demineralized water was provided ad libitum. The experiment was conducted for...
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Posted by admin on Mar 31, 2022 in |
Ondansetron hydrochloride (ONH) is an exceptionally harsh, powerful antiemetic drug utilized for the treatment and prophylaxis of chemotherapy or radiotherapy or postoperative prompted emesis. This investigation aims to detail and assesses taste-covered quick-dissolving tablets (FDTs) of ONH to expand patient consistence. ONH taste veiled granules were set up by a strong scattering procedure. Dissolvable dissipation techniques were utilized for such readiness. Totally taste veiling with zero arrival of medication in phosphate support pH 6.8 was acquired from granules arranged by dissolvable vanishing strategy utilizing drug: polymer proportion of 1:2, from which four equations pass a pre-pressure assessment and compacted to FDTs and assessed for their medication content, in-vitro breaking downtime, in-vivo deterioration time, wetting time and in-vitro drug discharge profile. It was tracked down that the tablet definitions F8 with cross carmellose sodium as super disintegrant showed the fast medication discharge when contrasted with unadulterated medication. T50 and DE 30% for the definition F8 was discovered to be in 7 min and 73.5%, Hence reasonable as quick-dissolving...
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Posted by admin on Mar 31, 2022 in |
Rheumatoid arthritis (RA) is a general inflammatory disorder touching about 1.3% of the grown-up census of the world. Over the last two decades, a significant development has been done in the thoughtfulness of RA pathophysiology, best outcomes, and successful treatment strategy, and the credit of the significance of diagnostic agents and treating RA near the beginning. Earlier than novel treatments were obtained, RA caused notable incapability and deaths. At present, it is customary that principal diagnostic agents and therapy are significant and helpful. Development in the treatment of RA made it likely to manipulate signs in inflammatory arthritis. The early hour diagnosis and treatment of RA can prevent or reduce the progression of joint erosion to about 90% of patients; by this means irreversible disability can be prevented. In advance and more effective treatment significantly improves the prognosis of RA. The advancement of novel instruments to assess disease activity and recognize remission has brought about innovative treatment strategies to inhibit RA ahead of joint damage forever. The pharmacological therapy...
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