Posted by admin on Mar 31, 2022 in |
Biosorption is a cure to atmosphere containing heavy metals and also an alternative to physical and chemical methods used for heavy metal removal. The main aim of this review is to highlight the various mechanisms of biosorption by using various biosorbent viz. microorganisms, no-living biomass, herbal plants for the removal of heavy metals. Industrialization, globalization has provided an ease to humans, but every comfort has its own disadvantages, in this case, it will increase heavy metal pollution which threatens the life of human, animals, and plants. Bio sorption used bio sorbent to remove heavy metal or sorbate and is economical. Nowadays, the natural biological material is used to remove heavy metals like vegetable waste and fruit peels. Herbal medicinal plants are also used to remove heavy...
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Posted by admin on Mar 31, 2022 in |
Costus igneus, commonly known as insulin plant, has been traditionally reported for its anti-diabetic, anti-oxidant, anti-inflammatory, anti-proliferative, anti-urolithiasis, hypolipidemic, neuroprotective and anti-microbial activity. This review is all about anatomical and morphological investigations of Costus igneus, including its medicinal use. Secondary metabolites of this plant such as b-sitostirol, corosolic acid, diosgenin, quercetin, catechine, oleic acid show mainly anti-diabetic activity. At present finding, Costus igneus have characteristic morphological, anatomical, and proximate features that could be used to differentiate it from other members of the Costaceae family. This review article collected information using the following searching engines such as Pub Med, Science Direct and Google Scholar, etc., and mainly focused on English written documents. The present review article attempts to explore various medicinal properties of Costus igneus (insulin plant) and mode of action of all major phytoconstituents as anti-diabetic activity for advanced research purposes and its suitable formulations development in the future for the welfare of...
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Posted by admin on Mar 31, 2022 in |
Pullulanase (Pullulanase-α-glucanohydrolase EC 3.2.1.41) is a glucanohydrolase enzyme that can break down the pullulan and allied oligosaccharides into glucose. Promising of starch-based industries are biofuels, starch syrup, nutraceuticals, etc., increase the glucanohydrolases demand. Present investigation revealing that the Bacillus cereus KKSJ 1981 is enhanced the production of pullulanase through the optimization of temperature, agitation speed, pH, soluble starch concentration, MnSO4 and yeast extract. Response surface methodology (RSM) was utilized to optimize the selected six parameters. A central composite design with 50 experiments was performed in this investigation. The analyzed data depicts that the correlation coefficient (R2) value was 0.9873, and the adjusted R2 value was 0.9717 indicates the high significance of the model. Further, the selected parameters in optimum conditions were predicted through the developed mathematical model, and validation experiments were performed at these conditions. Overall, 1.2 folds of pullulanase were improved through the RSM based...
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Posted by admin on Mar 31, 2022 in |
The research work is focused on the formulation of dermal drug delivery system of Fisetin. The formulation based on the principal to causes deeper skin penetration and minimal systemic delivery for the management of skin cancer by enhancing the dermal bioavailability of formulation with reducing dosage requirement in sustained delivery mode by direct targeting of formulations to the skin. Two formulations viz transethosome and ethsosme were formulated to attain the efficient dermal delivery of fisetin. The surface morphology was studied by using Zeta sizer procedures. The formulation had shown adequate strength, consistency, cohesiveness, and list of thickness as 330.50 g, 314.69 g, 2.34.50 g, and 112.71 g separately. The streamlined fisetin transethosome gel definition detailing had 90% spreadability and a pH of 6.5 ± 0.2. These properties guarantee uniform spreading of OFTF-gel at the application site without causing skin irritancy. OFTF-gel had shown great substance consistency with 99.5 ±1.5 % of medication recuperation from the gel by HPLC assessment. The skin treated with transethosomes gel had shown altogether higher...
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Posted by admin on Mar 31, 2022 in |
In the present study, the aqueous and ethanolic extracts of Vitis vinifera seeds were studied for alpha-amylase and alpha-glucosidase inhibition using an in-vitro model. The plant extracts were also examined for their antioxidant activities by using the free radical 1, 1-diphenyl-2-picryl hydrozyl (DPPH) scavenging method under in-vitro. The study revealed that the different concentrations of the extract possessed a very good amount of result and exhibited potent radical scavenging activity using DPPH SA substrate. The aqueous (68.5%) and ethanolic extract (74.2%) of Vitis vinifera seeds showed a significant inhibitory effect on alpha-amylase activity ethanol extract (74.2%), aqueous extract (68.5%). In the alpha-glucosidase activity ethanolic extract (75.7%) and aqueous extract (74.5%) showed a significant inhibitory effect when compared with standard acarbose drugs. Therefore, it is suggested that the aqueous and ethanolic extract of Vitis vinifera seeds could be used as a potential source for natural anti-diabetic and antioxidant compounds and could have the potential use in the management of diabetes mellitus and...
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