Posted by admin on Mar 31, 2021 in |
Tuberculosis is one of the major contagious diseases and a leading cause of death in humans. Current treatment methods suffer from a multitude of problems like long duration of treatment, lack of patient compliance, presence of drug-resistant bacteria, etc. To combat the disease effectively, there is an urgent need for the development of new drugs effective against both drug-sensitive and drug-resistant bacteria. Cynodon dactylon is known to be effective against cough and other lung diseases. The objective of the present study is to identify the component in Cynodon dactylon, which is therapeutically effective against Mycobacterium tuberculosis by in-silico docking analysis using Autodock. Here InhA, the enoyl acyl carrier protein reductase from Mycobacterium tuberculosis was taken as the target protein for docking analysis. Phytochemicals from Cynodon dactylon were selected based on molecular and ADME properties. Among the phytochemicals investigated, luteolin showed a good docking score and better interaction with the target protein and is comparable to the commercially available first-line antitubercular drug, isoniazid. Based on our preliminary analysis of molecular...
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Posted by admin on Mar 31, 2021 in |
Milk is a complex system where analysis of metal ions is a difficult task due to the presence of interfering materials. The formation of a coloured complex between the metal and a coloured or colourless ligand is the basis for the development of spectro-photometric methods. The aim of this study is to analyze and estimate copper present in various samples of milk (i.e., cow, buffalo, goat, camel, soya, and powdered milk) by micellar spectrophotometry method. For this purpose, the ligand N-(2’-Pyridyl)-2-hydroxy-benzamide (NPHB-2) was synthesized by the reaction of 2-aminopyridine with salicylic acid, which is a weak acid and is found to be soluble in alcohol, acetone, and chloroform. It is insoluble in water at a pH less than 7. In addition to the solution of this ligands to copper (II) solution in the presence of micellar medium, a yellowish-green or light green coloured complex is formed immediately. It has been observed that in the presence of a micellar medium, solubility, as well as absorption intensity, has been found to...
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Posted by admin on Mar 31, 2021 in |
As the incidences of Coronavirus (SARS CoV-2) infections have been increasing at a rapid pace, the need for its containment and treatment has taken center stage for numerous research institutions. The similarity of SARS CoV-2 with that of SARS CoV has led to a jumpstart in the research activities on corona-virus on the same. The number of research articles appearing since the time SARS CoV-2 was discovered has skyrocketed. While every research group has been busy in pushing the research information to the next level, hardly any convincing research has come up the effective treatments or therapeutics against the disease. In this study we conduct a bibliographic analysis for SARS CoV, MERS CoV and SARS CoV-2, and statistically compare the incidence of research articles combining along the “treatment” and ‘therapies” as keywords. We attempt to draw trends and conclusions based on the data available on the databases...
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Posted by admin on Mar 31, 2021 in |
The current coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the wholesale market in Wuhan, China in the last months of 2019 and spread to almost all countries of the world. Although several vaccines have already been developed in different countries of the world, there is currently no specific treatment for COVID-19. Some agents are used all over the world based on in-vitro, in-vivo studies, and randomized controlled studies. The number of studies on antiviral therapy has been increasing day by day. However, the efficacy of antiviral drugs for COVID-19 remains controversial. In this review, brief information about antiviral drugs favipiravir and remdesivir used for the treatment of COVID-19, the results of the conducted studies, and the possible adverse effects of these drugs are summarized. We hope that this review will provide an impression of favipiravir and remdesivir used to treat and control COVID-19 patients until the approval of specific drugs that target...
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Posted by admin on Mar 31, 2021 in |
Marine bacteria have the potentiality to produce diverse bioactive molecules such as pigment. Therefore, it needs to exploit and identifying a novel type of pigment from marine bacteria for Industrial applications. This study aimed to investigate the marine bacterial pigment against antioxidant and anti-cancer properties; the marine bacteria producing pigment were isolated from water samples collected at the coastal of Marakkanam (TN), India. The isolates were screened out based on the growth characteristics and performance of different media and the strain designated as MB4, which was taken as further studies. The strain MB4 characterized by SEM analysis showed that coccoid cell morphology, nonsporulating, Gram-positive with yellow pigmentation and positive for MR-VP, catalase, lipase, acetoin production, and hemolysis. The cells were able to tolerate 10 percent NaCl concentration and ability to grown pH 9. The MB4 strain was shown a higher wave-number (1395.77) cm-1 against Raman Intensity to identify pigment production. The methanolic extracted pigment was produced at a maximum peak at 260 nm. The yellow-pigmented crude extract checked for...
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