Posted by admin on Mar 31, 2021 in |
The World Health Organization (WHO) declared COVID -19 a pandemic on March 11 2020. As of today, there have been 122 million COVID -19-update cases worldwide, and the counting goes on. Unfortunately, strategic measures such as total lockdown, social and self-isolation, and gradual lifting of some of these restrictions both pose economic, social, and psychological distress and are thought to have affected people more than the virus itself. There is no specific antiviral drug available at this time. However, there are currently five main vaccines on the market that aim to protect the population from contracting the coronavirus. Moderna, Pfizer/BioNTech, Oxford/AstraZeneca, Sputnil V, and Sinopharm vaccines are among those included. Furthermore, developing an effective medication that is reliable for the treatment may be more effective, but it is more difficult. To accomplish this, molecular bio-interaction, virulence, clinical, and pathological features of COVID -19 viruses must be clearly understood. Additionally, the designation of potential antiviral drugs in the form of nanomedicines will optimize the therapeutic outcome and improve the quality of...
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Posted by admin on Mar 31, 2021 in |
Biosimilars are the most promising medicines for treating complex diseases. The first biosimilar was approved in India in 2000, and since then, there is no looking back. CDSCO in collaboration with DBT has developed new guidelines in 2012, which were revised in 2016 for pre and post-marketing approval of biosimilars in India. India is one of the leading manufacturers of biosimilars catering to domestic and international market. Soon it will have a vast opportunity to develop more similar biologics as the patent of many biologics is scheduled to expire by the year 2020. India has emerged well in global market of biosimilars. India started its journey with near about US$ 250 million biosimilar market in 2015 and it is estimated to reach around US$ 40 billion in India while US$ 240 billion in world by 2030. Biosimilars are the boon in treating...
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Posted by admin on Mar 31, 2021 in |
Coronaviruses are a group of viruses that belongs to the Coronaviridae family. These viruses have helical symmetry, enveloped, positive-sense, single-stranded RNA genome with nucleocapsid that causes diseases in birds and mammals. SARS-CoV 2 complete genome has genome size of 29,903 bp, having nine genes identified as Orf1a Polyprotein, Orf1ab Polyprotein, ORF3a Protein, ORF7a Protein, ORF8 Protein, Envelope proteins, Spike Surface glycoprotein, Membrane glycoprotein, and Nucleocapsid Phosphoprotein. Based on the ProtParam result, ORF1a has more molecular weight (489989 daltons), and Envelope protein has a less molecular weight (8365 daltons). The pI is lower in Orf1a polyprotein, Orf1ab Polyprotein, ORF3a Protein, ORF8 Protein, and Spike Surface glycoprotein) and high in ORF7a Protein, Envelope proteins, Membrane glycoprotein, and Nucleocapsid Phosphoprotein. The Orf1a Poly-protein, Orf1ab Polyprotein, ORF3a Protein, Envelope proteins, Spike Surface, and Membrane glycoprotein are stable. The higher aliphatic index and more hydrophobicity of membrane glycoprotein suggest an increase in the thermostability of protein might favor an increase in its solubility. The vaccines like EIAV vaccine gp45, anti-SARS m396 Antibody, EIAV vaccine...
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Posted by admin on Mar 31, 2021 in |
Objective: To assess the efficacy of Ma-ul-Sha’eer (Barley water) as a dietary intervention in Intermediate Hyperglycemic subjects. Methods: A hospital-based prospective, pre and post interventional studies, conducted on 40 diagnosed cases of Intermediate Hyperglycemia (Pre-diabetes) as per WHO and ADA criteria at OPD of Majeedia Unani Hospital and A & U Tibbia College and Hospital, Delhi. Results and Discussion: The efficacy of Ma-ul-Sha’eer (Barley water) was mainly observed on blood sugar fasting and HbA1c. The mean value of blood sugar fasting before the intervention was 113.6±6.7, and after the intervention was 103.0±5.4. Paired ‘t’ test was applied to the observations recorded before the intervention and after the intervention. It was observed that t=14.5 (p <0.0001) and were statistically highly significant. The most probable mechanism encountered in reducing blood sugar fasting may be the presence of β-glucan in Ma-ul-Sha’eer. The mean value of HbA1c before the intervention was 6.0±0.21 and after the intervention was 5.4±0.27, Paired‘t’ test was applied to the observations recorded before the intervention and after the intervention....
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Posted by admin on Mar 31, 2021 in |
Medicinal plants are one of the most important resources for developing new lead therapeutic compounds used in various traditional medicines worldwide for thousands of years due to the presence of natural bioactive components, which help in preventing various human diseases. Piper betle Linn belongs to the Piperaceae family, commonly known as Betel and Paan. Betel leaves possess several bioactivities, and these are used in traditional medicinal systems. Syzygium aromaticum L. (Cloves) is a tree belonging to the Myrtaceae family. Closed flowering buds are used as a spice in food preparations all over the world. Eugenol is an active compound of both plants (Piper betle and Syzygium aromaticum). Hence, we attempted to study the effect of the methanolic extracts of Piper betle and Syzygium aromaticum, along with their active component, eugenol, using an in-vitro approach. The in-vitro cytotoxicity was assessed against lung adenocarcinoma cell lines (A549) using the MTT and SRB assays, and the type of cell death was characterized by differential staining. The results showed that the plant extracts,...
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