Posted by admin on Jun 30, 2021 in |
Objective: The key objective of the study is to evaluate the Anti-Alzheimer activity of methanolic extracts of buchnania Lanzan leaves by Aluminum Chloride induced Alzheimer’s. Buchanania lanzan Spreng a well-known forest plant of the family Anacardiaceae. It is reported to have numerous uses in the indigenous system of medicine in India. Material and Methods: Albino Wistar rats were administered with AlCl3 at a dose of 4.2 mg/kg/day i.p. for 4 weeks. Experimental rats were given Buchnania Lanzan Leaf extract in two different doses of 200 mg and 400 mg/kg/day orally 1hr before the AlCl3 administration for 4 weeks. Learning and memory parameters were evaluated using elevated plus maze (EPM), Radial Arm Maze, and T Maze paradigms. Results: The preliminary phytochemical investigation of Buchnania Lanzan Extract showed the presence of carbohydrates, alkaloids, flavonoids, phenols, tannins, saponins. In this study, Buchnania lanzan leaves extract was an administration for 28 days showed significant neuroprotective activity in aluminum chloride-induced rats of cognitive impairment and oxidative stress analyzed by using various behavioral Studies. Conclusion:...
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Posted by admin on Jun 30, 2021 in |
The medicinal plant Ricinus communis is one of the effective plants which offer a solution to several kinds of diseases. Owing to this, the present research aims to review the medicinal properties of one of such common herbal plants, Ricinus communis, its possible role as herbal medicine, and assessment for pharma-covigilance. Related research articles were collected from Google Scholar, Pub Med, Science direct, Scientific information Database, and Scopus. For the present study purpose, using the term Ricinus communis, the castor bean, and castor oil plant in the title of all articles published to 2021 were observed. Phytochemical constituents of R. communis like saponins, flavonoids, alkaloids, steroids, and glucosides. Leaves of the plant have shown the presence of major phenolic compounds. Whereas roots test has presented the Indole-3-acetic. The findings reflect that the plant contains high medicinal benefits, which offer a solution for several kinds of diseases like cancer, diabetes, ulcer and anthelmintic, etc. Also, the plant is anti-inflammatory property of the plant facilitates therapeutic use. Therefore, all parts of...
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Posted by admin on Jun 30, 2021 in |
Scopoletin (7-hydroxy-6-methoxy coumarin) is a phenolic coumarin isolated from many plants, known as an important compound of the phytoalexin group. This article is created to provide information regarding the synthesis and pharmacological activity of scopoletin. Scopoletin has been found in many plant species and isolated from various parts of the plant (roots, fruits, leaves, stems, etc.) such as Morinda citrifolia, Aegle marmelos, Erycibe obtusifolia Benth, Lasianthus lucidus Blume, Melia azedarach L., Sinomonium acutum, Convolvulus prostratus, and Solanum lyratum, etc. which all possess a number of medicinal properties. Its various pharmacological activities have been reported through a number of investigations. It is reported that such compounds produced specific biological activities and possible health implications for humans in food and medicine. Pharmacological activities that are established in-vivo are antithyroid, antihypertensive, anti-proliferative, anti-inflammatory, neuro-logical, anti-dopaminergic and anti-adrenergic, antidiabetic drug, and anti-hyperuricemic activities. Based on in-vitro studies, scopoletin has pharmacological activities, including an antihepatotoxicity, antibacterial, antifungal, antitubercular, and antioxidant. From the assorted pharmaco-logical activities of scopoletin, it has the potential to be further...
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Posted by admin on Jun 30, 2021 in |
Postoperative atrial fibrillation (POAF) is a frequent rhythm disturbance after cardiac surgery and is associated with poor cardiovascular outcomes. Beta-blocker therapy is an effective strategy to prevent or decrease the high incidence of POAF and β1-adrenergic receptor (β1AR) polymorphisms that affect the cardiac response to β1AR antagonists. The study objective is to analyze the association between genetic variations in the β1AR gene and the risk of POAF and the prophylactic effect of beta-blockers. Totally, 198 patients undergoing first-time cardiac surgery were examined. The patients after operation were grouped as either with POAF or without POAF according to their continuously electrocardiogram monitoring within ICU and hospital admission period. Subsequently, genotype frequencies of the β1AR gene were determined by polymerase chain reaction-restriction fragment length polymorphism. The results showed that 63 patients (31.8%) of the total study population developed POAF. After the application of a multivariate logistic regression model, the incidence of POAF was associated with Arg389Gly genotype (OR=2.48; 95% CI, 1.06-5.76; p=0.036), Arg389Arg genotype (OR=3.38; 95% CI, 1.28-9.33; p=0.018) and Arg389Ser49...
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Posted by admin on Jun 30, 2021 in |
Inflammatory bowel diseases (IBD) are chronic and relapsing intestinal inflammatory conditions, hallmarked by a disturbance in the bidirectional interaction between gut and brain. IBD is Ulcerative colitis (UC) and Crohn‘s disease (CD). Conventional therapies are inadequate and are associated with several systemic side effects due to lack to localization of active moiety at the inflamed site. Treatment option range from small molecules to macromolecules (peptides, proteins and oligonucleotides) that target multiple therapeutic pathways, and dosed via injectable, oral or the rectal route for local bowel treatment. Conventional therapies are inadequate and are associated with several systemic side effects due to a lack of localization of active moiety at the inflamed site. But colonic drug targeting is a novel, potentially active area of research intended and focused on drug delivery for treating localized disease. Targeted drug delivery to the colon would ensure direct treatment at the disease site, lower dosing, and fewer systemic side...
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