Posted by admin on Jul 31, 2015 in |
Objective: The current study was designed to study Acute Dermal Irritation potential of Mastilep gel (supplied by M/S Ayurvet Limited, Baddi, India) according to OECD guidelines. Materials and Methods: Mastilep gel, a new herbal ointment for topical use applied on the udder, has been developed as an alternative method for controlling mastitis in ruminants. Mastilep gel’s active ingredients including herbal extracts of Cedrus deodara, Curcuma longa, Glycyrrhiza glabra and Eucalyptus globulus are expected for their antibacterial, anti-inflammatory, analgesic, antihistaminic and immunomodulatory effects. For new substances it is the recommended stepwise testing approach for developing scientifically sound data on the corrosivity/irritation of the substance. Three female rabbits were used for the study. Each animal served as its own control. After application of Mastilep gel the degree of irritation/corrosion was read and scored. Results: No severe erythema, oedema or any skin lesion was observed after Mastilep gel application. The results revealed no irritation potential of Mastilep gel. Conclusion: MASTILEP gel is safe for...
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Posted by admin on Jul 31, 2015 in |
Today, humans and wildlife are constantly exposed to thousands of chemical residues, through air, food and water. Organochlorines are widespread pollutants and comprise a variety of compounds containing carbon, hydrogen, and chlorine. Chlorinated insecticides, solvents, and fumigants are widely used around the world. Exposure to organochlorine chemicals has been associated with many deleterious effects on human health. Concerns have been raised about their implication in reproductive toxicity and endocrine disruption, because organochlorine chemicals persist in the environment. Organochlorines interfere with normal hormonal function in animals and humans. Reproductive abnormalities, including feminization of males, abnormal sexual behavior, birth defects, altered sex ratios, decreased sperm production, reduced testicular size, infertility, and thyroid dysfunction, have been reported in laboratory animals and wildlife exposed to endocrine-disrupting chemicals. This review deals with adverse effects of different organochlorine chemicals on male reproductive system, thus indicates limited use of organochlorines to improve the quality of life for human...
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Posted by admin on Jul 31, 2015 in |
The present work aimed at formulating a solid self micro emulsifying drug delivery system (solid-SMEDDS) for Olmesartan Medoxomil with the objective of improving the aqueous solubility, dissolution and oral delivery of the drug. Liquid SMEDDS of the drug were formulated using Capmul MCM as the oil phase, Tween 80 and Phenoxide HCO-40 as the combined surfactants after screening various vehicles. The prepared systems were characterized for various physicochemical characteristics. Ternary phase diagrams were plotted to identify the area of micro emulsification. The optimized liquid SMEDDS was transformed into a free flowing powder using Neusilin US2 as the adsorbent. The physical state of the drug in solid self micro emulsifying powder was revealed by Differential Scanning Calorimetric and X– ray powder diffraction studies which indicated the presence of the drug in the dissolved form in the lipid excipients. These findings were supported by scanning electron microscopy studies which did not show the evidence of precipitation of the drug on the surface of the carrier. Moreover the droplet size of the...
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Posted by admin on Jul 31, 2015 in |
Objective: Maternal Mortality: Ten year review study in The Department of Obstetrics and Gynecology, Goa Medical College. Method: A retrospective study was conducted in the Dept. of OBG GMC over a period of10 years spanning between Jan 4 to Dec 13 regarding Maternal Mortality. Results: There were total of 58 deaths out of 54604 live births during this 10 year period giving maternal mortality ratio(MMR) of 106.15/ 100000 live births which is 50% less as compared to MMR in India(212 maternal deaths/100,000 live births). In last 2 years i.e. in 2012 and 2013 it has come down 86.35-94.46 maternal deaths/100,000 live births, thus already reaching MDG 5 of WHO Referral cases accounted 87.85%. The majority of cases were in 21-30 year age group (93.2%) and mostly they were primigravida (55.1%). Hemorrhage (29cases) was the commonest cause of death followed by pregnancy induced hypertension (26cases). Conclusion: Hemorrhage (PPH, accidental hemorrhage, ruptured uterus), pregnancy induced hypertension including eclampsia, HELP Syndrome, Sepsis and DIC were found to be the direct major causes...
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Posted by admin on Jul 31, 2015 in |
Chalcones and its derivatives show various biological activities. The present study deals with the synthesis of series of 2-hydroxy-3-nitro-5-methyl–N-substituted phenyl chalcone imines from 2-hydroxy-3-nitro-5-methylphenyl chalcone and different substituted aromatic animes in ethanol in presence of 2, 3 drops of Conc. H2SO4. Structures of synthesized compounds have been established by spectral (IR, NMR, etc.) and elemental analysis. In the present communication we report the synthesis substituted chalcone imines and its antimicrobial activity against pathogenic bacteria and fungi. The sensitivity carried out by disc diffusion method displayed significant antimicrobial...
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