Posted by admin on Aug 1, 2010 in |
A series of 3- (5- substituted phenyl- 1, 3, 4- Oxadiazol- 2- yl) pyridines was designed, synthesized and characterized for evaluation of potential antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Klebsiella species and antifungal activity against Candida albicans. Structure-activity relationship led to the conculsion that compound IVb, and IVe exhibited good antibacterial activity against Bacillus subtilis and Staphylococcus aureus and comparatively poor activity against Klbesiella species and Escherichia coli. Compound C exhibited antibacterial activity against Staphylococcus aureus and very poor activity against rest of organism. Compounds IVa, IVb and IVe showed poor antifungal activity against Candida albicans and compounds IVc and IVd showed no significant antifungal activity. The interesting antimicrobial profile of compound IVb and IVe led us to select this derivative for further development. Present research our expected compounds were given below....
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Posted by admin on Aug 1, 2010 in |
AIM: The aim of this study was to analyze the efficacy and safety of concurrent chemotherapy with Cisplatin, Paclitaxel and radiotherapy on survival, functional and quality of life outcomes in locally advanced carcinoma of larynx. MATERIALS & METHODS: From June 2004 to Sep 2006, seventy four inoperable, previously untreated, histopathologically proven, locally advanced patients of carcinoma larynx were planned to be treated with radical EBRT- 56 Gy and concurrent weekly chemotherapy with Cisplatin 30 mg/m2 and 5FU 400 mg/m2 placed in Group A and Group B patients were given RT with concomitant chemotherapy Cisplatin30 mg/m2, Paclitaxel 60 mg/m2 IV weekly up to 4 weeks and after a gap of two weeks all patients were given 20 Gy by reduced field without chemotherapy in both groups . RESULTS: Follow up of patient was done up to September 2008. The duration of follow up was in the range of 16-18 months. Parameters studied were local control, complication, recurrence and mortality. Nearly 79% of patients of Group B had complete response after...
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Posted by admin on Aug 1, 2010 in |
Floating matrix tablets of metformin hydrochloride were developed and evaluated for increase bioavailability by increasing gastric residence time and sustained release of drug on the upper part of gastrointestinal tract thereby diminishing side effects and enhanced patient compliance. Metformin hydrochloride, an oral antidiabetic having narrow absorption window in the upper part of gastrointestinal tract, was formulated as floating matrix tablet using gas generating agent (potassium bicarbonate) and hydrophilic gelling polymer hydroxyl propyl methyl cellulose (hypromellose) by wet granulation technique. The prepared formulations were evaluated for floating time and in vitro drug release characteristics using modified dissolution method. All formulations possessed good floating properties with total floating time more than 12 hours. Optimization study included 22 factorial design with t50% and t80% as the kinetic parameters. Matrix characterization included photomicrograph, which showed definite entrapment of the drug in the matrix. Formulations with high amount of hypromellose were found to float for longer duration and provide more sustained release of drug. The formulated drug delivery system was found to be independent...
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Posted by admin on Aug 1, 2010 in |
A series of 6- methyl- 2 – oxo N- (4- oxo- 2- substituted phenyl- 1, 3- thiazolidin- 3- yl)- 4- substituted phenyl- 1, 2, 3, 4- tetrahydropyrimidine- 5- carboxamide have been synthesized and evaluated for their anti-inflammatory activity by carrageenan induced rat paw edema method. The reaction was carried out simply by heating a mixture of three components dissolved in ethanol with a catalytic amount of hydrochloric acid at reflux temperature. The product of this novel one pot, tree-component synthesis that precipitated on cooling of the reaction mixture was identified correctly by Biginelli as 3, 4- dihydropyrimidine- 2 (1H) – one. The synthetic potential of this new heterocyclic synthesis remained unexplored for quite some time. In the 1970s and 1980s interest slowly increased, and the scope of the original cyclocondensation reaction was gradually extended by variation of all three building blocks, allowing access to a large number of multi functionalized dihydropyrimidines. The resulting dihydropyrimidinones and their sulphur analogs posses antibacterial, antiviral, antitumor, anti-inflammatory, antihypertensive as well as calcium channel...
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Posted by admin on Aug 1, 2010 in |
A simple reverse phase HPLC method was developed for the simultaneous estimation of Ranitidine hydrochloride and Domperidone present in combined tablet dosage forms. Efficient chromatographic separation was achieved on Phenomenax C18 stationary phase (250 X 4.6 mm i. d., 5μ particle size) with simple mobile phase combination of phosphate buffer: acetonitrile: methanol 40: 30: 30 (V/V/V) in an isocratic mode at a flow rate of 1.5 mLmin-1 at 210 nm. The retention times were 2.417 and 7.375 (±0.5) min for Ranitidine hydrochloride and Domperidone respectively. The proposed method has been applied successfully for the simultaneous analysis of Ranitidine hydrochloride and Domperidone in combined tablet dosage form with good accuracy and precision. The method herein described can be employed for quality control and routine analysis of Ranitidine hydrochloride and Domperidone in pharmaceutical dosage...
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