Posted by admin on Jul 31, 2019 in |
Paclitaxel is one of the best anti-cancer drugs and recently known as the best anti-cancer products of natural origin. The purpose of the present work was to study the physicochemical properties and compatibility of paclitaxel with the selected surfactants employed in nanocrystal formulations. The melting point and loss on drying of paclitaxel were found 216 °C and 0.11% respectively. A log P value of paclitaxel in different solvent systems like Octanol-Water, Dichloromethane-Water, Hexane-Water, and Oleyl Alcohol-Water was found 2.66, 2.91, 3.02 and 3.42 respectively. Paclitaxel is insoluble in water, soluble in ethanol, dichloromethane, and DMSO (dimethyl sulphoxide). The compatibility analysis of Paclitaxel with Egg lecithin, Poly Vinyl Pyrrolidine (PVP) and Poly (L‐lactic acid‐co‐glycolic acid) (PLGA) was studied by employing Fourier transform infrared spectroscopy (FTIR), X-Ray Powder Diffraction (XRPD) and Differential Scanning Calorimetry (DSC) techniques. FTIR, XRPD and DSC methods applied to the mentioned physical mixtures did not show evidence of interactions in the solid state. Based on these results supplied by FTIR, DSC, and XRPD, all the surfactants were...
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Posted by admin on Jul 31, 2019 in |
Indian coastline stretches about 5700 km covering 9 states on the mainland and about 7500 km including islands and union territories. Seaweeds, a renewable natural resource, found growing in large quantities along the Indian coast. Seaweeds are currently worldwide interest in finding new and safe promising organisms for health. It is one of the important essential producers of biomass in the marine environment. Seaweeds are not only of high ecological but also of great economic importance as they produce a wide variety of chemically active metabolites in their surroundings. The potential uses of algal biomass for the benefit of mankind have been intensively reviewed in the last few years. Marine algae have been used as a novel food with potential nutritional benefits in industry and medicine for various purposes. Furthermore, marine algae have shown to provide a rich source of natural bioactive compounds with antidiabetic, hepatoprotective, antiviral, antifungal, antibacterial, antioxidant, anti-inflammatory, anti-hypercholesterolemia and hypolipidemic and antineoplastic properties, etc. The present review is focusing on the bioactivities and potential pharmacological...
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Posted by admin on Jul 31, 2019 in |
The present study was designed to investigate the antioxidant and immunomodulatory activity of Azathioprine-Pioglitazone combination therapy to check whether it has added on benefit over monotherapy with Azathioprine or Pioglitazone in rodent models. The test drugs in combination showed better inhibition of free radicals in both H2O2 radical scavenging assay and nitric oxide scavenging assay than individual counterparts revealing its potential antioxidant activity. The combination showed its significant effect on both cell-mediated and humoral immunity to suppress stimulated immune responses in delayed-type hypersensitivity test, carbon clearance test, and nitro blue tetrazolium test. The study proved that Pioglitazone enhances the antioxidant and immunomodulatory activity of Azathioprine indicating the possible synergistic interaction between...
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Posted by admin on Jul 31, 2019 in |
In the present study the 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one isolated from the methanolic extract of leaves of Andrographis echioides was studied for alpha-amylase and alpha-glucosidase inhibition using an in-vitro model. The isolation was done using column chromatography using gradient elution with different mobile phase. Structural elucidation was carried out on the basis of spectral analysis. The study revealed that the 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one exhibited significant α-amylase and α-glucosidase inhibitory activities with an IC50 value of 36.2 ± 0.42 and 41.4 ± 0.34% respectively and well compared with standard acarbose drug. The infra-red spectrum specific absorption bands for 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one viz. 3401.71 (O-H stretching vibration of phenol), 1666.95 (C=O Aryl ketonic stretch), 1612.42 (C-C Aromatic ring stretch), 1519.96 (C=O aromatic stretch), 1463.09 (C=C aromatic stretch), 1380.89 (O-H bending of phenols), 1318.98 (C-H bond in Aromatic hydrocarbon), 1246.04 (C-O stretch of Aryl ether), 1213.26 (C-O stretch of phenol), 1169.06 (C-CO-C stretch and bending in ketone), 932.62, 807.89, 702.92, 638.65 (C-H bending of aromatic hydrocarbons). Structural elucidation of 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one was done by spectrum analysis such as 13C and...
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Posted by admin on Jul 31, 2019 in |
Introduction: Thymus vulgaris (za’atar) is one of the most famous and traditional spices of Arab countries. Extracts of Thymus vulgaris (zatar) found to be useful as traditional medicine. The current studies are aiming to further explore the phytoconstituents of Thymus vulgaris and its biological activity. Methodology: The present study investigated the phytochemical constituent of za’atar and fractionated with organic solvents using the classical method. Biological activity was done as an immunomodulatory activity, anti-bacterial, cytotoxic and anti-cancer activity in-vitro. Results: Hundred gram of ethanolic crude extract was prepared from za’atar leaves using classical method and fractionated with organic solvents (n-hexane, chloroform, ethyl acetate, and n-butanol) yielding 20 g, 16 g, 8 g and 18 g of each fraction respectively, phytochemical studies showed positive results for alkaloids, carbohydrates/glycosides, tannins, flavonoids, and triterpenes/sterols. All fractions except butanol showed potential immunomodulatory activity. Mild, significant antibacterial activity was found in chloroform fraction. Whereas, ethyl acetate and n-butanol samples exhibited significant activity against E. coli. Our results demonstrated that ethanolic extract of za’atar possesses significant...
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