Posted by admin on Jul 31, 2019 in |
Inhaled Pharmacological therapy is key to treatments for patients with asthma and COPD. People who suffered from COPD died every year in low- and middle-income countries. The primary reason for COPD is tobacco smoking or second-hand smoke. Another risk factor is air pollution, dust, and fumes. Current guidelines endorsed inhaled pharmacology therapy as the favorable route of administration for treating COPD. Bronchodilators (β2 agonists and antimuscarinics) are the anchor of the pharmacology therapy in patients with COPD, with long-acting approved for patients with ordinary to serious symptoms or those who are at higher risk for COPD aggravations. Dry powder inhaler (DPI) pressurized metered dose inhaler (pMDI) is the frequently used drug delivery devices, but they may be sparse in various clinical scenarios. There are a lot of drugs become available in solutions; suspensions form to treat patients suffered from COPD with nebulized drug delivery, which supplies benefits similar to drugs delivered by the conventional delivery system and better quality of life. A successful pulmonary administration requires a harmonic interaction...
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Posted by admin on Jul 31, 2019 in |
Diabetes or Madhumeha as per Ayurveda is a disease in which there is improper functioning of insulin and as a result, the sugar level in the blood increases. Diabetes may cause heart problem, kidney failure, blurred vision if not treated timely with proper medication. Medicinal plants have been used since ancient times for the treatment and management of diabetic mellitus (DM) in traditional medicine systems of many cultures throughout the world. Traditional Medicines derived from medicinal plants are used by about 60% of the world’s population. Recently, the World Health Organization (WHO) recommended the use of medicinal plants for the management of DM and further encouraged the expansion of the frontiers of scientific evaluation of hypoglycemic properties of diverse plant species. This review focuses on Indian Herbal drugs and plants used in the treatment of diabetes, especially in...
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Posted by admin on Jul 31, 2019 in |
The purpose of the present study was to explore the effect of co-administration of bioenhancer quercetin on membrane permeability of poorly permeable berberine chloride, on goat intestinal membrane model. The effect of co-administration of quercetin was investigated at 2, 6, and 10 mg concentrations. The study revealed a beneficial effect of low concentration of quercetin on % cumulative drug release (% CDR) of the drug under treatment. The co-administration process resulted in remarkable improvement in the permeability of berberine chloride (% CDR 28.33 ± 1.87) at 2 mg of quercetin. On the contrary, the permeability of berberine chloride was decreased (% CDR 10.46 ± 1.55) at 10 mg concentration of quercetin as compared to berberine chloride alone (% CDR 8.49 ± 1.45 at 10 mg). Apparent permeability coefficient, flux, and enhancement ratio were also found to be increased significantly with decreasing concentration of quercetin as compared with the control. It could be concluded that the use of quercetin will be beneficial for co-administration to enhance the permeability, bioavailability, and...
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Posted by admin on Jul 31, 2019 in |
Introduction: Antioxidant properties of flavonoids may guard against oxidative damage to cells, DNA, or lipids. The ample literature about flavonoids can affirm the structural and pharmacological cherishing of this class of phytochemicals. The presence of aromatic rings in the flavonoid molecule consent the receiving and donation of electrons from free radical species, which abets to curb the free radicals. Methodology: This is a prospective observational study conducted on diabetic patient’s over-period of one year in the outpatient department of a tertiary care teaching Hospital. Red blood cells (RBC) were separated from the 20 ml of blood samples, which have been collected from the 90 subjects. The collected RBC were divided into four equal parts for which superoxide dismutase, catalase, and glutathione peroxidase activity was estimated with and without the flavonoids. The absorbance was recorded in a spectrophotometer. Results and Discussion: The results symbolize a significantly higher superoxide dismutase, catalase, and glutathione peroxidase activities for quercetin than kaempferol and chrysin. Quercetin is more effective on Superoxide dismutase followed by kaempferol and chrysin. But there...
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Posted by admin on Jul 31, 2019 in |
A simple, accurate, rapid and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous determination of Aspirin (ASP) and Omeprazole (OMP). By using box benchen design method have been developed and optimized. Effective chromatographic separation achieved using C18 column (250 × 4.6 mm, 5 µm) as a stationary phase and mobile phase consisted of methanol: Disodium hydrogen phosphate buffer (68: 32 v/v), pH adjusted to 4.5 with phosphoric acid at a flow rate 1.15 mL/min at a detection wavelength of 280 nm. Analytical Quality by Design approach was applied to evaluate the effect of three factors are the volume of the organic phase in the mobile phase, pH of mobile phase and flow rate on chromatographic responses like retention time and tailing factor. The retention time of ASP and OMP were found to be 2.94 and 5.87 min respectively. Calibration curves were found to be linear over the concentration range of 10-60 µg/mL for ASP and 5-30 µg/mL for OMP. The % recovery of...
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