Posted by admin on Jul 31, 2019 in |
Herbal medication has attracted much attention in recent years and is being used as an alternative to chemical medicines. Some evidence supports the positive effects of medicinal plants in the prevention and treatment of different types of diseases. Thymoquinone (TQ) is the most abundant component of Nigella sativa seeds, and most of the properties of Nigella sativa are attributed primarily to TQ. It belongs to a class of naturally presenting phenols, chemically known as 2-isopropyl-5-methyl benzo-1, 4-quinone (C10H12O2), is a dark yellow crystalline monoterpene diketone, abundantly found in the seeds of Nigella sativa. Besides Nigella sativa, TQ is an active ingredient of several plants as Juniperus, Monarda, Coridothymus, Agastache, Satureja. It has been reported to possess various beneficial therapeutic effects including anti-oxidant, anti-inflammatory, anti-microbial, anti-diabetic, hepato-protective and cardioprotective effects. It is significant to say that TQ may be effective as a powerful contender of natural origin with therapeutic potential against an array of...
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Posted by admin on Jul 31, 2019 in |
Introduction: Type 2 diabetes, which is the most common type, is often a result of excess body weight and physical inactivity in genetically predisposed individuals. Over due course of time diabetes can cause blindness, kidney damage, neurological problems, and coronary artery disease. Improvement in glycemic control is important factors in delaying the onset and progression of diabetes-related complications. In spite of the availability of newer antidiabetic drugs, prevention of complication is still a challenge. Nishamalaki, Patoladi Yoga and Shobhanjan are the Ayurvedic formulations claimed to be effective in preventing nephrotoxicity. Objective: To evaluate the therapeutic efficacy of Nishamalaki, Patoladi Yoga, and Shobhanjan in diabetic nephropathy. Materials and Methods: Total of 36 Wistar rats were used for the study. Diabetes was induced in 30 Wistar rats of either sex with STZ (35 mg/kg) i.p followed by High Fat High Fructose diet (HFHF), (coconut oil+ vanaspati) till the development of Diabetic nephropathy (10wks) which was confirmed by Sr. creatinine, blood urea levels. Out of six groups included in the study, group...
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Posted by admin on Jul 31, 2019 in |
This work aimed to evaluate the quality of some commercial peppermint oil products available in the Egyptian market. Also, analysis of peppermint oil extracted from Mentha piperita L. leaves marketed in Egypt. Thus, quality control of both herb extracted and purchased oil products. Essential oils were analyzed using GC/MS, and the main ingredients of each peppermint oil sample were quantified. The antioxidant potential for each of the tested six oil samples was performed using the DPPH radical scavenging assay using ascorbic acid as a reference standard. Also, their EC50% values were calculated. The quality of the samples had been evaluated according to the European Pharmacopeia limits for each of the major peppermint oil components. Thus, menthol, menthone, menthyl acetate, carvone, and pulegone percent composition in each sample was used to evaluate its quality. All the tested samples were found to possess strong to moderate antioxidant activities with EC50% values ranged from 20.44 and 66.10 depending on the oil chemical composition variation. Percent composition of the major peppermint oil components...
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Posted by admin on Jul 31, 2019 in |
The interest in using natural and chemically modified polysaccharides as a part of drug development has increased in the past two decades. For potential carriers in controlled, modulated drug delivery, great interest has also been focused on biopolymer-based hydrogels. Due to their advantages like biocompatibility, biodegradability, and low cost, biopolymers have been widely used in the development of hydrogels. Indeed, by tuning the physicochemical properties of the hydrogels with varying the degree of crosslinking either by chemical or physical or physical-chemical means these networks can be made suitable as the modulated drug delivery devices. In this present review, a focus is made on various natural polymers and their mechanism to form cross-linked hydrogel beads with suitable cations and various methods of preparation of beads. Here, it was also tried to explain the significance of polyelectrolyte complexation and ionotropic gelation approaches, as these methods show great pledge as a tool for the development of the encapsulation process and also plays an important role in controlled and modulated drug delivery...
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Posted by admin on Jul 31, 2019 in |
The present research work was considered to achieve preliminary phytochemical screening, acute oral toxicity, antioxidant activity, and to evaluate the antihyperlipidemic property of the aqueous and ethanolic extracts of leaves of Amaranthus tricolor. Antioxidant activities of the aqueous and ethanolic extracts of leaves of Amaranthus tricolor were investigated by Free Radical Scavenging Activity (DPPH method) and antihyperlipidemic activity by in-vivo effects on an atherogenic diet (2% cholesterol, 1% choline chloride and 2% Lard) induced rats hyperlipidemia. Our results exposed that Amaranthus tricolor showed potent antioxidant properties. In the cholesterol-induced hyperlipidemic model, groups of rats treated with extracts A. tricolor showed a significant reduction in total cholesterol (TC), triglycerides (TG) and in levels of SGOT, SGPT, ALP, LDH, and CKMB activities whereas increase in the level of high-density lipoprotein (HDL) compared to cholesterol-induced hyperlipidemic control group at dose-dependent manner but the effect was less than the standard drug Atorvastatin. It was observed from the histopathological findings that rats fed with A. tricolor extracts showed a decrease in granular degeneration caused...
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